Purpose: This study aimed to compare the performance of radiomics and deep learning in predicting EGFR mutation status in patients with lung cancer based on PET/CT images, and tried to explore a model with excellent prediction performance to accurately predict EGFR mutation status in patients with non-small cell lung cancer (NSCLC).Method: PET/CT images of 194 NSCLC patients from Xijing Hospital were collected and divided into a training set and a validation set according to the ratio of 7:3. Statistics were made on patients’ clinical characteristics, and a large number of features were extracted based on their PET/CT images (4306 radiomics features and 2048 deep learning features per person) with the pyradiomics toolkit and 3D convolutional neural network. Then a radiomics model (RM), a deep learning model (DLM), and a hybrid model (HM) were established. The performance of the three models was compared by receiver operating characteristic (ROC) curves, sensitivity, specificity, accuracy, calibration curves, and decision curves. In addition, a nomogram based on a deep learning score (DS) and the most significant clinical characteristic was plotted.Result: In the training set composed of 138 patients (64 with EGFR mutation and 74 without EGFR mutation), the area under the ROC curve (AUC) of HM (0.91, 95% CI: 0.86–0.96) was higher than that of RM (0.82, 95% CI: 0.75–0.89) and DLM (0.90, 95% CI: 0.85–0.95). In the validation set composed of 57 patients (32 with EGFR mutation and 25 without EGFR mutation), the AUC of HM (0.85, 95% CI: 0.77–0.93) was also higher than that of RM (0.68, 95% CI: 0.52–0.84) and DLM (0.79, 95% CI: 0.67–0.91). In all, HM achieved better diagnostic performance in predicting EGFR mutation status in NSCLC patients than two other models.Conclusion: Our study showed that the deep learning model based on PET/CT images had better performance than radiomics model in diagnosing EGFR mutation status of NSCLC patients based on PET/CT images. Combined with the most statistically significant clinical characteristic (smoking) and deep learning features, our hybrid model had better performance in predicting EGFR mutation types of patients than two other models, which could enable NSCLC patients to choose more personalized treatment schemes.

This study proposes a novel, to the best of our knowledge, transformer-based end-to-end network (TDNet) for point cloud denoising based on encoder–decoder architecture. The encoder is based on the structure of a transformer in natural language processing (NLP). Even though points and sentences are different types of data, the NLP transformer can be improved to be suitable for a point cloud because the point can be regarded as a word. The improved model facilitates point cloud feature extraction and transformation of the input point cloud into the underlying high-dimensional space, which can characterize the semantic relevance between points. Subsequently, the decoder learns the latent manifold of each sampled point from the high-dimensional features obtained by the encoder, finally achieving a clean point cloud. An adaptive sampling approach is introduced during denoising to select points closer to the clean point cloud to reconstruct the surface. This is based on the view that a 3D object is essentially a 2D manifold. Extensive experiments demonstrate that the proposed network is superior in terms of quantitative and qualitative results for synthetic data sets and real-world terracotta warrior fragments.

To obtain a higher simplification rate while retaining geometric features, a simplification framework for the point cloud is proposed. Firstly, multi-angle images of the original point cloud are obtained with a virtual camera. Then, feature lines of each image are extracted by deep neural network. Furthermore, according to the proposed mapping relationship between the acquired 2D feature lines and original point cloud, feature points of the point cloud are extracted automatically. Finally, the simplified point cloud is obtained by fusing feature points and simplified non-feature points. The proposed simplification method is applied to four data sets and compared with the other six algorithms. The experimental results demonstrate that our proposed simplification method has the superiority in terms of both retaining geometric features and high simplification rate.

This paper presents an improved method to estimate the blur parameters of motion deblurring algorithm for single image restoration based on the point spread function (PSF) in frequency spectrum. We then introduce a modification to the Radon transform in the blur angle estimation scheme with our proposed difference value vs angle curve. Subsequently, the auto-correlation matrix is employed to estimate the blur angle by measuring the distance between the conjugated-correlated troughs. Finally, we evaluate the accuracy, robustness and time efficiency of our proposed method with the existing algorithms on the public benchmarks and the natural real motion blurred images. The experimental results demonstrate that the proposed PSF estimation scheme not only could obtain a higher accuracy for the blur angle and blur length, but also demonstrate stronger robustness and higher time efficiency under different circumstances.