One of the main challenges of the twenty-first century is to increase the sustainability level of our cities. However, a town, to be considered sustainable, must, above all, be safe, particularly against natural hazards, which in Europe are mostly related to climate changes (e.g., hurricanes, floods, storms, and landslides) and seismic events (earthquakes). Unfortunately, sustainability is still not a prerogative of most European cities, especially those placed in seismic countries such as Italy, where at least 50% of the residential stock is earthquake-prone, while over 80% of the same stock is highly energy-consuming and carbon dioxide-emitting, thus contributing to trigger hazards related to climate changes. In this context, renovation actions, which combine both energy and seismic issues are strongly needed. Nevertheless, several technical, organizational and financial barriers considerably limit the real possibility to extensively undertake this kind of renovation. This study analyzes such barriers, with particular reference to the Italian scenario, suggesting and discussing possible solutions and underlining the advantages of increasing energy and seismic performances at the same time. The proposed solutions may be effectively extended to many other countries with similar socio-economic scenarios.