Medical images have made a great contribution to early diagnosis. In this study, a new strategy is presented for analyzing medical images of skin with melanoma and nevus to model, classify and identify lesions on the skin. Machine learning applied to the data generated by first and second order statistics features, Gray Level Co-occurrence Matrix (GLCM), keypoints and color channel information—Red, Green, Blue and grayscale images of the skin were used to characterize decisive information for the classification of the images. This work proposes a strategy for the analysis of skin images, aiming to choose the best mathematical classifier model, for the identification of melanoma, with the objective of assisting the dermatologist in the identification of melanomas, especially towards an early diagnosis.