In this pilot study, we analyzed effects of transcranial photobiomodulation (tPBM, 1267 nm, 32 J/cm2) on clearance of beta-amyloid (Aβ) from the mouse brain. The immunohistochemical and confocal data clearly demonstrate the significant reduction of deposition of Aβ plaques in mice after tPBM vs. untreated animals. The behavior tests showed that tPBM improved the cognitive, memory and neurological status of mice with Alzheimer's disease (AD). Using of our original method based on optical coherence tomography (OCT) analysis of clearance of gold nanorods (GNRs) from the brain, we proposed possible mechanism underlying tPBM-stimulating effects on clearance of Aβ via the lymphatic system of the brain and the neck. These results open breakthrough strategies for a non-pharmacological therapy of Alzheimer's disease and clearly demonstrate that tPBM might be a promising therapeutic target for preventing or delaying Alzheimer's disease.

In this paper, measurements of the optical properties (diffuse reflectance, total and collimated transmittance) of brain tissues in healthy rats and rats with C6-glioma were performed in the spectral range from 350 to 1800 nm. Using these measurements, characteristic tissue optical parameters, such as absorption coefficient, scattering coefficient, reduced scattering coefficient, and scattering anisotropy factor were reconstructed. It was obtained that the 10-day development of glioma led to increase of absorption coefficient, which was associated with the water content elevation in the tumor. However, further development of the tumor (formation of the necrotic core) led to decrease in the water content. The dependence of the scattering properties on the different stages of model glioma development was more complex. Light penetration depth into the healthy and tumor brain was evaluated.

Alzheimer’s disease (AD) is an incurable pathology associated with progressive decline in memory and cognition. Phototherapy might be a new promising and alternative strategy for the effective treatment of AD, and has been actively discussed over two decades. However, the mechanisms of therapeutic photostimulation (PS) effects on subjects with AD remain poorly understood. The goal of this study was to determine the mechanisms of therapeutic PS effects in beta-amyloid (Aβ)-injected mice. The neurological severity score and the new object recognition tests demonstrate that PS 9 J/cm² attenuates the memory and neurological deficit in mice with AD. The immunohistochemical assay revealed a decrease in the level of Aβ in the brain and an increase of Aβ in the deep cervical lymph nodes obtained from mice with AD after PS. Using the in vitro model of the blood-brain barrier (BBB), we show a PS-mediated decrease in transendothelial resistance and in the expression of tight junction proteins as well an increase in the BBB permeability to Aβ. These findings suggest that a PS-mediated BBB opening and the activation of the lymphatic clearance of Aβ from the brain might be a crucial mechanism underlying therapeutic effects of PS in mice with AD. These pioneering data open new strategies in the development of non-pharmacological methods for therapy of AD and contribute to a better understanding of the PS effects on the central nervous system.

Currently, a new interdisciplinary field of research – financial behaviour-is rapidly developing. Psychological characteristics of the subject of financial behaviour can have a significant impact on the decision-making process in this field. Cognitive style, as an individual way of processing the information perceived by the subject, is one of the factors determining such procedural features of financial decision-making as: the time spent on decision – making, the speed of decision-making, the emotional state of the individual during decision-making, the nature of perceptual information processing (especially oculomotor activity), as well as the type of decision strategy - rational, irrational or marginal.

Introduction. Folk art is the basis of spiritual and moral education. Given that folk art is entering our lives in a new way, the chosen topic is relevant. Theoretical analysis. Gzhel and Khokhloma have accompanied the development of artistic taste over the centuries. It is known about the influence of art on the psycho-emotional state of a person, an indicator of which is oculomotor activity. Eye movements can be used as indicators of the perceptual process. Empirical analysis. The characteristic values of blinking, fixations and saccades were revealed during the perception of images of Gzhel and Khokhloma, taking into account the preference for one or another folk art. It has been established that those who prefer Gzhel use a contemplative strategy of observation, while those who choose Khokhloma use a research one. Also, when considering blue-white images, persons who have chosen Gzhel use a rational way of perception, and when perceiving gold images, they use an emotional one. Participants who preferred Khokhloma showed an inverse ratio of perception methods. Conclusion. When considering folk art, different ways of processing information are actualized among people who prefer Gzhel and Khokhloma. The identified features of oculomotor activity will make it possible to use these types of folk art in art therapy when conducting additional research.