Manganese dioxide (MnO₂) nanosheets have shown exciting potential in nanomedicine because of their ultrathin thickness, large surface area, high near-infrared (NIR) absorbance and good biocompatibility. However, the effect of MnO₂ nanosheets on bacteria is still unclear. In this study, MnO₂ nanosheets were shown for the first time to possess highly efficient antibacterial activity by using Salmonella as a model pathogen. The growth curve and surface plate assay uncovered that 125 μg/mL MnO₂ nanosheets could kill 99.2% of Salmonella, which was further verified by fluorescence-based live/dead staining measurement. Mechanism analysis indicated that MnO₂ nanosheet treatment could dramatically induce reactive oxygen species production, increase ATPase activity and cause the leakage of electrolytes and protein contents, leading to bacterial death. These results uncover the previously undefined role of MnO₂ nanosheets and provide novel strategies for developing antimicrobial agents.

We have studied the X-ray nuclear activity of 187 nearby (distance < 15 Mpc) galaxies observed with Chandra/ACIS. We found that 86 of them have a point-like X-ray core, consistent with an accreting black hole (BH). We argue that the majority of them are nuclear BHs, rather than X-ray binaries. The fraction of galaxies with an X-ray detected nuclear BH is higher (~60 per cent) for ellipticals and early-type spirals (E to Sb), and lower (~30 per cent) for late-type spirals (Sc to Sm). There is no preferential association of X-ray cores with a large-scale bar; in fact, strongly barred galaxies appear to have slightly lower detection fraction and luminosity for their nuclear X-ray sources, compared with non-barred or weakly barred galaxies of similar Hubble types. The cumulative luminosity distribution of the nuclear sources in the 0.3-8 keV band is a power-law with slope ~-0.5, from ~2 x 10^{38} erg/s to ~10^{42} erg/s. The Eddington ratio is lower for ellipticals (L_{X}/L_{Edd} ~ 10^{-8}) and higher for late-type spirals (up to L_{X}/L_{Edd} ~ 10^{-4}), but in all cases, the accretion rate is low enough to be in the radiatively-inefficient regime. The intrinsic NH is generally low, especially for the less luminous sources: there appear to be no Type-2 nuclear BHs at luminosities <~ 10^{39} erg/s. The lack of a dusty torus or of other sources of intrinsic absorption (e.g., an optically-thick disk wind) may be directly related to the lack of a standard accretion disk around those faint nuclear BHs. The fraction of obscured sources increases with the nuclear BH luminosity: 2/3 of the sources with L_{X} > 10^{40} erg/s have a fitted NH > 10^{22} cm^{-2}. This is contrary to the declining trend of the obscured fraction with increasing luminosities, observed in more luminous AGN and quasars.