This paper investigates for the first time how the implementation of semiconductor optical amplifier (SOA)-based devices in photonic networks can negatively impact the integrity of two-dimensional wavelength-hopping time-spreading (2D-WH/TS) optical code-division multiple access (OCDMA) codes based on multi-wavelength picosecond code carriers. It is demonstrated and confirmed by simulations that the influence of an SOA under driving currents of 50 mA to 250 mA causes a 0.08 to 0.8 nm multi-wavelength picosecond code carriers’ wavelength redshift. The results obtained are then used to calculate the degradation of OCDMA system performance in terms of the probability of error Pe and the decrease in the number of simultaneous users. It is shown that, when the SOA-induced 0.8 nm code carriers redshift becomes equal to the code carries wavelength channel spacing, the (8,53)-OCDMA system performs only as a (7,53)-OCDMA system, and the number of simultaneous users drops from 14 to 10 or 84 to 74 with the forward error correction (FEC) Pe of 10⁻⁹, respectively. The impact of the 0.8 nm redshift is then shown on a (4,53)-OCDMA system, where it causes a drop in the number of simultaneous users from 4 to 3 or 37 to 24 with the FEC Pe of 10⁻⁹, respectively.