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The aim of this study was twofold: (1) to test for differences on the external and internal responses encountered by youth soccer players during four bouts of 5-a-side small-sided game (SSG) across age categories and, (2) to analyze the external and internal responses attending to players’ sprinting and jumping profile within each age-category (i.e. under 14 (U14), under 16 (U16) and under 18 (U18)). Forty-eight young soccer players participated in this study and were distributed by each age-category. Players were classified based on jumping-profile (stronger and weaker) and sprint-profile (faster and slower). Also, players played four bouts of 4 min of a 5-a-side SSG, including goalkeepers. Likewise, external responses (i.e. total distance, distance covered at walking, jogging and high-intensity speeds, number of accelerations and decelerations, body impacts and player load) and internal responses (peak heart rate, % of peak heart rate and training impulse) were collected. The main results revealed a significant age-category by bout interaction for total distance covered, distance at jogging, number of accelerations, body impacts and player load for players from the U16 and U18 age categories, showing lower values during the last bouts, compared to the first bouts ( p ≤ 0.001–0.020, [Formula: see text] = 0.13–0.17). Moreover, while no significant ( p = 0.09–0.95) sprint-profile by bout interaction was found for the registered variables across age categories, stronger U18 players showed a smaller decrease across bouts for distance covered at high-intensity, compared to weaker U18 players. These findings suggest there is a need for coaching staff to include training strategies that allow for reducing accumulated neuromuscular fatigue in U16 and U18 age categories.
Daniel Castillo; Javier Yanci; Javier Raya-González; Ángel Lago-Rodríguez. Influence of players’ physical performances on the variation of the external and internal responses to repeated bouts of small-sided games across youth age categories. Proceedings of the Institution of Mechanical Engineers, Part P: Journal of Sports Engineering and Technology 2021, 1 .
AMA StyleDaniel Castillo, Javier Yanci, Javier Raya-González, Ángel Lago-Rodríguez. Influence of players’ physical performances on the variation of the external and internal responses to repeated bouts of small-sided games across youth age categories. Proceedings of the Institution of Mechanical Engineers, Part P: Journal of Sports Engineering and Technology. 2021; ():1.
Chicago/Turabian StyleDaniel Castillo; Javier Yanci; Javier Raya-González; Ángel Lago-Rodríguez. 2021. "Influence of players’ physical performances on the variation of the external and internal responses to repeated bouts of small-sided games across youth age categories." Proceedings of the Institution of Mechanical Engineers, Part P: Journal of Sports Engineering and Technology , no. : 1.
The potential ergogenic effect of nutritional supplements depends on their dosage and the type of exercise executed. Aiming at reviewing the research literature regarding sport supplements utilized in judo in order to improve performance, a literature search was performed at the following databases: Dialnet, PubMed, Scielo, Scopus and SportDiscus. A total of 11 articles met the inclusion criteria and were selected. Evidence revised indicates that supplementation with caffeine, β-alanine, sodium bicarbonate, creatine, and β-hydroxy-β-methylbutyrate has a positive effect on judo-related performance. Moreover, there is evidence suggesting that combining some of these nutritional supplements may produce an additive effect.
Leonardo Simoncini; Ángel Lago-Rodríguez; Álvaro López-Samanes; Alberto Pérez-López; Raúl Domínguez. Effects of Nutritional Supplements on Judo‐Related Performance: A Review. Journal of Human Kinetics 2021, 77, 81 -96.
AMA StyleLeonardo Simoncini, Ángel Lago-Rodríguez, Álvaro López-Samanes, Alberto Pérez-López, Raúl Domínguez. Effects of Nutritional Supplements on Judo‐Related Performance: A Review. Journal of Human Kinetics. 2021; 77 (1):81-96.
Chicago/Turabian StyleLeonardo Simoncini; Ángel Lago-Rodríguez; Álvaro López-Samanes; Alberto Pérez-López; Raúl Domínguez. 2021. "Effects of Nutritional Supplements on Judo‐Related Performance: A Review." Journal of Human Kinetics 77, no. 1: 81-96.
Objective: The aim of this study was to investigate the effects of caffeine supplementation on: (i) psychological responses of subjective vitality and mood; (ii) performance through a Wingate test; and (iii) rate of perceived exertion (RPE) reported after a Wingate test. Methods: Fifteen male participants (22.60 ± 2.16 years) ingested 6 mg·kg-1 of caffeine or placebo (sucrose) supplementation in two experimental sessions. After 60 min from supplement intake, participants fulfilled two questionnaires, which measured subjective vitality and mood state, respectively. Subsequently, participants’ performance was assessed through a Wingate test, which was followed by measurements of RPE at general, muscular, or cardiovascular level. Results: Caffeine supplementation increased some components of mood, as assessed by profile of mood states (POMS) (tension and vigor dimensions) and subjective vitality profiles, which were followed by a greater maximum power, average power, and lower time needed to reach maximum power during the Wingate test. Moreover, lower RPE, both at muscular and general levels were reported by participants after the Wingate test. Conclusions: These results suggest that caffeine supplementation exerts positive effects both in psychological and physical domains in trained subjects.
Raúl Domínguez; Pablo Veiga-Herreros; Antonio Jesús Sánchez-Oliver; Juan José Montoya; Juan José Ramos-Álvarez; Francisco Miguel-Tobal; Ángel Lago-Rodríguez; Pablo Jodra. Acute Effects of Caffeine Intake on Psychological Responses and High-Intensity Exercise Performance. International Journal of Environmental Research and Public Health 2021, 18, 584 .
AMA StyleRaúl Domínguez, Pablo Veiga-Herreros, Antonio Jesús Sánchez-Oliver, Juan José Montoya, Juan José Ramos-Álvarez, Francisco Miguel-Tobal, Ángel Lago-Rodríguez, Pablo Jodra. Acute Effects of Caffeine Intake on Psychological Responses and High-Intensity Exercise Performance. International Journal of Environmental Research and Public Health. 2021; 18 (2):584.
Chicago/Turabian StyleRaúl Domínguez; Pablo Veiga-Herreros; Antonio Jesús Sánchez-Oliver; Juan José Montoya; Juan José Ramos-Álvarez; Francisco Miguel-Tobal; Ángel Lago-Rodríguez; Pablo Jodra. 2021. "Acute Effects of Caffeine Intake on Psychological Responses and High-Intensity Exercise Performance." International Journal of Environmental Research and Public Health 18, no. 2: 584.
This study was performed aimed at comparing multidirectional bilateral and unilateral jump performance and passive range of motion (ROM) of lower limbs between soccer and basketball young players and evaluating associations between inter-limb ROM asymmetry and bilateral jump performance. A total of 67 young male athletes participated in this study, who were classified as soccer (n = 40; 15.55 ± 1.5 y; 1.76 ± 0.12 m; 58.15 ± 10.82 kg; 19.84 ± 2.98 kg·m2) and basketball (n = 27; 15.7 ± 1.66 y; 1.76 ± 0.12 m; 62.33 ± 16.57 kg; 19.84 ± 2.98 kg·m2) players. Participants were asked to perform bilateral and unilateral multidirectional jumps, and passive ROM of hip (flexion, extension and abduction), knee (flexion) and ankle (dorsiflexion) joints was also assessed. Significant between-group differences were observed for hip extension with flexed knee ROM in dominant (soccer: 142.43 ± 7.74°; basketball: 148.63 ± 8.10°) and non-dominant (soccer: 144.38 ± 8.36°; basketball: 148.63 ± 6.45°) legs; hip flexion with flexed knee ROM in dominant (soccer: 13.26 ± 4.71°; basketball: 9.96 ± 3.42°) and non-dominant (soccer: 12.86 ± 4.55°; basketball: 9.70 ± 3.62°) legs; and for the ratio of hip abduction (soccer: 1.02 ± 0.08; basketball: 0.97 ± 0.11). However, no significant between-group differences were observed for bilateral and unilateral jump capacity, or for inter-limb asymmetries (dominant vs. non-dominant leg). Finally, no associations were observed between ROM ratio (dominant vs. non-dominant leg) and bilateral jump performance. These findings lead to the suggestion that differences on passive ROM values in young male athletes may be sport-specific. Additionally, there seems to be need for the implementation of training strategies specifically aimed at improving bilateral or unilateral jump ability, or at diminishing inter limb passive ROM differences in order to improve multidirectional jump performance for neither soccer nor basketball youth male players.
Marta Domínguez-Díez; Daniel Castillo; Javier Raya-González; Silvia Sánchez-Díaz; María Soto-Célix; Tara Rendo-Urteaga; Ángel Lago-Rodríguez. Comparison of multidirectional jump performance and lower limb passive range of motion profile between soccer and basketball young players. PLOS ONE 2021, 16, e0245277 .
AMA StyleMarta Domínguez-Díez, Daniel Castillo, Javier Raya-González, Silvia Sánchez-Díaz, María Soto-Célix, Tara Rendo-Urteaga, Ángel Lago-Rodríguez. Comparison of multidirectional jump performance and lower limb passive range of motion profile between soccer and basketball young players. PLOS ONE. 2021; 16 (1):e0245277.
Chicago/Turabian StyleMarta Domínguez-Díez; Daniel Castillo; Javier Raya-González; Silvia Sánchez-Díaz; María Soto-Célix; Tara Rendo-Urteaga; Ángel Lago-Rodríguez. 2021. "Comparison of multidirectional jump performance and lower limb passive range of motion profile between soccer and basketball young players." PLOS ONE 16, no. 1: e0245277.
Dietary nitrate (NO3−) supplementation, which can enhance performance in exercise settings involving repeated high-intensity efforts, has been linked to improved skeletal muscle contractile function. Although muscular strength is an important component of explosive movements and sport-specific skills, few studies have quantified indices of muscular strength following NO3− supplementation, particularly isokinetic assessments at different angular velocities. We performed a systematic review and meta-analysis to determine whether dietary NO3− supplementation improves peak torque, as assessed by the gold standard method of isokinetic dynamometry, and if this effect was linked to the angular velocity imposed during the assessment. Dialnet, Directory of Open Access Journals, MEDLINE, PubMed, SciELO, Scopus, and SPORTDiscus were searched for articles using the following search strategy: (nitrate OR beet*) AND (supplement* OR nutr* OR diet*) AND (isokinetic OR strength OR “resistance exercise” OR “resistance training” OR “muscular power”). The meta-analysis of data from 5 studies with 60 participants revealed an overall effect size of −0.01 for the effect of nitrate supplementation on isokinetic peak torque, whereas trivial effect sizes ranging from −0.11 to 0.16 were observed for independent velocity-specific (90°/s, 180°/s, 270°/s, and 360°/s) isokinetic peak torque. Four of the five studies indicated that dietary NO3− supplementation is not likely to influence voluntary knee extensor isokinetic torque across a variety of angular velocities. These results suggest that NO3− supplementation does not influence isokinetic peak torque, but further work is required to elucidate the potential of NO3− supplementation to influence other indices of muscular strength, given the dearth of experimental evidence on this topic.
Ángel Lago-Rodríguez; Raúl Domínguez; Juan José Ramos-Álvarez; Francisco Miguel Tobal; Pablo Jodra; Rachel Tan; Stephen J. Bailey. The Effect of Dietary Nitrate Supplementation on Isokinetic Torque in Adults: A Systematic Review and Meta-Analysis. Nutrients 2020, 12, 3022 .
AMA StyleÁngel Lago-Rodríguez, Raúl Domínguez, Juan José Ramos-Álvarez, Francisco Miguel Tobal, Pablo Jodra, Rachel Tan, Stephen J. Bailey. The Effect of Dietary Nitrate Supplementation on Isokinetic Torque in Adults: A Systematic Review and Meta-Analysis. Nutrients. 2020; 12 (10):3022.
Chicago/Turabian StyleÁngel Lago-Rodríguez; Raúl Domínguez; Juan José Ramos-Álvarez; Francisco Miguel Tobal; Pablo Jodra; Rachel Tan; Stephen J. Bailey. 2020. "The Effect of Dietary Nitrate Supplementation on Isokinetic Torque in Adults: A Systematic Review and Meta-Analysis." Nutrients 12, no. 10: 3022.
Dietary nitrate (NO3−) supplementation has been evidenced to induce an ergogenic effect in endurance and sprint-type exercise, which may be underpinned by enhanced muscle contractility and perfusion, particularly in type II muscle fibers. However, limited data are available to evaluate the ergogenic potential of NO3− supplementation during other exercise modalities that mandate type II fiber recruitment, such as weightlifting exercise (i.e., resistance exercise). In this systematic review, we examine the existing evidence basis for NO3− supplementation to improve muscular power, velocity of contraction, and muscular endurance during weightlifting exercise in healthy adults. We also discuss the potential mechanistic bases for any positive effects of NO3− supplementation on resistance exercise performance. Dialnet, Directory of Open Access Journals, Medline, Pubmed, Scielo, Scopus and SPORT Discus databases were searched for articles using the keywords: nitrate or beetroot and supplement or nut*r or diet and strength or “resistance exercise” or “resistance training” or “muscular power”. Four articles fulfilling the inclusion criteria were identified. Two of the four studies indicated that NO3− supplementation could increase aspects of upper body weightlifting exercise (i.e., bench press) performance (increases in mean power/velocity of contraction/number of repetitions to failure), whereas another study observed an increase in the number of repetitions to failure during lower limb weightlifting exercise (i.e., back squat). Although these preliminary observations are encouraging, further research is required for the ergogenic potential of NO3− supplementation on weightlifting exercise performance to be determined.
Alejandro F. San Juan; Raul Dominguez; Ángel Lago-Rodríguez; Juan José Montoya; Rachel Tan; Stephen J. Bailey. Effects of Dietary Nitrate Supplementation on Weightlifting Exercise Performance in Healthy Adults: A Systematic Review. Nutrients 2020, 12, 2227 .
AMA StyleAlejandro F. San Juan, Raul Dominguez, Ángel Lago-Rodríguez, Juan José Montoya, Rachel Tan, Stephen J. Bailey. Effects of Dietary Nitrate Supplementation on Weightlifting Exercise Performance in Healthy Adults: A Systematic Review. Nutrients. 2020; 12 (8):2227.
Chicago/Turabian StyleAlejandro F. San Juan; Raul Dominguez; Ángel Lago-Rodríguez; Juan José Montoya; Rachel Tan; Stephen J. Bailey. 2020. "Effects of Dietary Nitrate Supplementation on Weightlifting Exercise Performance in Healthy Adults: A Systematic Review." Nutrients 12, no. 8: 2227.
Ángel Lago Rodríguez; Pablo Jodra; Stephen Bailey; Raúl Domínguez. Caffeine improves performance but not duration of the countermovement jump phases. 2020, 1 .
AMA StyleÁngel Lago Rodríguez, Pablo Jodra, Stephen Bailey, Raúl Domínguez. Caffeine improves performance but not duration of the countermovement jump phases. . 2020; ():1.
Chicago/Turabian StyleÁngel Lago Rodríguez; Pablo Jodra; Stephen Bailey; Raúl Domínguez. 2020. "Caffeine improves performance but not duration of the countermovement jump phases." , no. : 1.
The aim of this study was twofold: 1) To compare players’ physical performance and small-sided game (SSG) external responses among three young soccer age categories (i.e., under 14 (U14), under 16 (U16), and under 18 (U18)); and 2) to examine their relationships among physical performance and SSG external responses in each age category. Players’ physical performance was evaluated via several tests and external responses were collected during a four vs. four plus goalkeepers SSG. Main results showed that while older players presented better linear straight sprinting tests (LSSTs) (U18 and U16 vs. U14, p < 0.01), repeated sprint ability (RSA) (U18 vs. U16 and U14 p < 0.01), and change of direction ability (CODA) (U18 and U16 vs. U14, p < 0.01, ES = 2.34−2.72) performances, these differences were not consistent with their SSG external responses (U16 vs. U14, p < 0.01; U18 vs. U16, p < 0.01). Conversely, higher number of associations between players’ physical performance and SSG external responses were found in younger players in comparison to the older ones. These results suggest that while greater physical performance in younger players (i.e., U14) could allow them to exhibit higher external responses, greater physical performance did not influence older players’ (i.e., U18) SSG external responses.
Daniel Castillo; Angel Lago-Rodríguez; Marta Domínguez-Díez; Silvia Sánchez-Díaz; Tara Rendo-Urteaga; María Soto-Célix; Javier Raya-González. Relationships between Players’ Physical Performance and Small-Sided Game External Responses in a Youth Soccer Training Context. Sustainability 2020, 12, 4482 .
AMA StyleDaniel Castillo, Angel Lago-Rodríguez, Marta Domínguez-Díez, Silvia Sánchez-Díaz, Tara Rendo-Urteaga, María Soto-Célix, Javier Raya-González. Relationships between Players’ Physical Performance and Small-Sided Game External Responses in a Youth Soccer Training Context. Sustainability. 2020; 12 (11):4482.
Chicago/Turabian StyleDaniel Castillo; Angel Lago-Rodríguez; Marta Domínguez-Díez; Silvia Sánchez-Díaz; Tara Rendo-Urteaga; María Soto-Célix; Javier Raya-González. 2020. "Relationships between Players’ Physical Performance and Small-Sided Game External Responses in a Youth Soccer Training Context." Sustainability 12, no. 11: 4482.
Background Caffeine supplementation (CAFF) has an established ergogenic effect on physical performance and the psychological response to exercise. However, few studies have compared the response to CAFF intake among athletes of different competition level. This study compares the acute effects of CAFF on anaerobic performance, mood and perceived effort in elite and moderately-trained recreational athletes. Methods Participants for this randomized, controlled, crossover study were 8 elite athletes (in the senior boxing national team) and 10 trained-recreational athletes. Under two experimental conditions, CAFF supplementation (6 mg/kg) or placebo (PLAC), the athletes completed a Wingate test. Subjective exertion during the test was recorded as the rating of perceived exertion (RPE) both at the general level (RPEgeneral) and at the levels muscular (RPEmuscular) and cardiorespiratory (RPEcardio). Before the Wingate test, participants completed the questionnaires Profiles of Moods States (POMS) and Subjective Vitality Scale (SVS). Results In response to CAFF intake, improvements were noted in Wpeak (11.22 ± 0.65 vs 10.70 ± 0.84; p = 0.003; $$ {\eta}_p^2 $$ηp2=0.44), Wavg (8.75 ± 0.55 vs 8.41 0.46; p = 0.001; $$ {\eta}_p^2 $$ηp2 =0.53) and time taken to reach Wpeak (7.56 ± 1.58 vs 9.11 ± 1.53; p < 0.001; $$ {\eta}_p^2 $$ηp2 =0.57) both in the elite and trained-recreational athletes. However, only the elite athletes showed significant increases in tension (+ 325%), vigor (+ 31%) and SVS (+ 28%) scores after the intake of CAFF compared to levels recorded under the condition PLAC (p < 0.05). Similarly, levels of vigor after consuming CAFF were significantly higher in the elite than the trained-recreational athletes (+ 5.8%). Conclusions CAFF supplementation improved anaerobic performance in both the elite and recreational athletes. However, the ergogenic effect of CAFF on several mood dimensions and subjective vitality was greater in the elite athletes.
P. Jodra; Ángel Lago Rodríguez; A. J. Sánchez-Oliver; A. López-Samanes; A. Pérez-López; P. Veiga-Herreros; A. F. San Juan; R. Domínguez. Effects of caffeine supplementation on physical performance and mood dimensions in elite and trained-recreational athletes. Journal of the International Society of Sports Nutrition 2020, 17, 1 -11.
AMA StyleP. Jodra, Ángel Lago Rodríguez, A. J. Sánchez-Oliver, A. López-Samanes, A. Pérez-López, P. Veiga-Herreros, A. F. San Juan, R. Domínguez. Effects of caffeine supplementation on physical performance and mood dimensions in elite and trained-recreational athletes. Journal of the International Society of Sports Nutrition. 2020; 17 (1):1-11.
Chicago/Turabian StyleP. Jodra; Ángel Lago Rodríguez; A. J. Sánchez-Oliver; A. López-Samanes; A. Pérez-López; P. Veiga-Herreros; A. F. San Juan; R. Domínguez. 2020. "Effects of caffeine supplementation on physical performance and mood dimensions in elite and trained-recreational athletes." Journal of the International Society of Sports Nutrition 17, no. 1: 1-11.
The aim of this study was to analyze the influence of the relative age effect (RAE) on the selection and promotion processes in an elite soccer academy. One hundred and eleven elite youth players who belonged to an elite soccer club from the Spanish “La Liga” participated in this study. Players were classified into three age-categories: under 14 years (U14), under 16 years (U16) and under 18 years (U18); and they were also classified in quartiles based on their date of birth (i.e., January-March, Q1; April-June, Q2; July-September, Q3; October-December, Q4). In addition, two further classification criteria were established based on the selection (i.e., selected and non-selected players) and promotion (i.e., promoted and non-promoted players) processes. The main results showed that in U14 and U16 age-categories, players born early in the year were over-represented compared to players born late in the year, although birth-distribution was not associated with the likelihood of a player to be selected or promoted. In addition, less fat in sum skinfolds, less percentage of fat, higher percentage of muscle and lower endomorphy and mesomorphy components were showed in U14 selected players, in comparison with non-selected players. Likewise, better sprint performance was found in U16 selected players versus non-selected ones. However, no significant differences on anthropometry, body composition, somatotype and physical performance were found between promoted and non-promoted players. Therefore, our results suggest there is need for coaches to reorient their talent identification programs in order to make sure that players selected to continue playing in the club have the potential to promote to the excellence in soccer.
Daniel Castillo; Benito Pérez-González; Javier Raya-González; Álvaro Fernández-Luna; Pablo Burillo; Ángel Lago-Rodríguez. Selection and promotion processes are not associated by the relative age effect in an elite Spanish soccer academy. PLOS ONE 2019, 14, e0219945 .
AMA StyleDaniel Castillo, Benito Pérez-González, Javier Raya-González, Álvaro Fernández-Luna, Pablo Burillo, Ángel Lago-Rodríguez. Selection and promotion processes are not associated by the relative age effect in an elite Spanish soccer academy. PLOS ONE. 2019; 14 (7):e0219945.
Chicago/Turabian StyleDaniel Castillo; Benito Pérez-González; Javier Raya-González; Álvaro Fernández-Luna; Pablo Burillo; Ángel Lago-Rodríguez. 2019. "Selection and promotion processes are not associated by the relative age effect in an elite Spanish soccer academy." PLOS ONE 14, no. 7: e0219945.
Prolonged exposure to movement perturbations leads to creation of motor memories which decay towards previous states when the perturbations are removed. However, it remains unclear whether this decay is due only to a spontaneous and passive recovery of the previous state. It has recently been reported that activation of reinforcement-based learning mechanisms delays the onset of the decay. This raises the question whether other motor learning mechanisms may also contribute to the retention and/or decay of the motor memory. Therefore, we aimed to test whether mechanisms of error-based motor adaptation are active during the decay of the motor memory. Forty-five right-handed participants performed point-to-point reaching movements under an external dynamic perturbation. We measured the expression of the motor memory through error-clamped (EC) trials, in which lateral forces constrained movements to a straight line towards the target. We found greater and faster decay of the motor memory for participants who had access to full online visual feedback during these EC trials (Cursor group), when compared with participants who had no EC feedback regarding movement trajectory (Arc group). Importantly, we did not find between-group differences in adaptation to the external perturbation. In addition, we found greater decay of the motor memory when we artificially increased feedback errors through the manipulation of visual feedback (Augmented-Error group). Our results then support the notion of an active decay of the motor memory, suggesting that adaptive mechanisms are involved in correcting for the mismatch between predicted movement trajectories and actual sensory feedback, which leads to greater and faster decay of the motor memory.
Ángel Lago Rodríguez; R. Chris Miall. Online Visual Feedback during Error-Free Channel Trials Leads to Active Unlearning of Movement Dynamics: Evidence for Adaptation to Trajectory Prediction Errors. Frontiers in Human Neuroscience 2016, 10, 1 .
AMA StyleÁngel Lago Rodríguez, R. Chris Miall. Online Visual Feedback during Error-Free Channel Trials Leads to Active Unlearning of Movement Dynamics: Evidence for Adaptation to Trajectory Prediction Errors. Frontiers in Human Neuroscience. 2016; 10 ():1.
Chicago/Turabian StyleÁngel Lago Rodríguez; R. Chris Miall. 2016. "Online Visual Feedback during Error-Free Channel Trials Leads to Active Unlearning of Movement Dynamics: Evidence for Adaptation to Trajectory Prediction Errors." Frontiers in Human Neuroscience 10, no. : 1.
Loss of dopamine, a key modulator of synaptic signalling, and subsequent pulsatile non-physiological levodopa replacement is believed to underlie altered neuroplasticity in Parkinson's disease (PD). Animal models suggest that maladaptive plasticity (e.g. deficient depotentiation at corticostriatal synapses) is key in the development of levodopa-induced dyskinesia (LID), a common complication following levodopa replacement in PD. Human studies using transcranial magnetic stimulation protocols have shown similar depotentiation deficit in patients with LID. We hypothesized that subtle depotentiation deficits should precede LID if these deficits are mechanistically linked to LID onset. Moreover, patients on pulsatile levodopa-based therapy may show these changes earlier than those treated with levodopa-sparing strategies. We recruited 22 early non-dyskinetic PD patients (<5 years since diagnosis) and 12 age-matched healthy controls. We grouped patients into those on Levodopa-Based (n = 11) and Levodopa-Sparing therapies (n = 11). Patients were selected to obtain groups matched for age and disease severity. We used a theta-burst stimulation protocol to investigate potentiation and depotentiation in a single session. We report significant depotentiation deficits in the Levodopa-Based group, compared to both Levodopa-Sparing and Healthy Control groups. Potentiation and Depotentiation responses were similar between Levodopa-Sparing and Healthy Control groups. Although differences persist after accounting for potential confounds (e.g. levodopa-equivalent dose), these results may yet be caused by differences in disease severity and cumulative levodopa-equivalent dose as discussed in the text. In conclusion, we show for the first time that paradoxical facilitation in response to depotentiation protocols can occur in PD even prior to LID onset.
Ángel Lago Rodríguez; Viviana Ponzo; Ned Jenkinson; Sonia Benitez-Rivero; Miguel Fernandez Del-Olmo; Michele Hu; Giacomo Koch; Binith Cheeran. Paradoxical facilitation after depotentiation protocol can precede dyskinesia onset in early Parkinson’s disease. Experimental Brain Research 2016, 234, 3659 -3667.
AMA StyleÁngel Lago Rodríguez, Viviana Ponzo, Ned Jenkinson, Sonia Benitez-Rivero, Miguel Fernandez Del-Olmo, Michele Hu, Giacomo Koch, Binith Cheeran. Paradoxical facilitation after depotentiation protocol can precede dyskinesia onset in early Parkinson’s disease. Experimental Brain Research. 2016; 234 (12):3659-3667.
Chicago/Turabian StyleÁngel Lago Rodríguez; Viviana Ponzo; Ned Jenkinson; Sonia Benitez-Rivero; Miguel Fernandez Del-Olmo; Michele Hu; Giacomo Koch; Binith Cheeran. 2016. "Paradoxical facilitation after depotentiation protocol can precede dyskinesia onset in early Parkinson’s disease." Experimental Brain Research 234, no. 12: 3659-3667.
Despite increasing evidence suggesting the cerebellum works in concert with the cortex and basal ganglia, the nature of the reciprocal interactions between these three brain regions remains unclear. This consensus paper gathers diverse recent views on a variety of important roles played by the cerebellum within the cerebello-basal ganglia-thalamo-cortical system across a range of motor and cognitive functions. The paper includes theoretical and empirical contributions, which cover the following topics: recent evidence supporting the dynamical interplay between cerebellum, basal ganglia, and cortical areas in humans and other animals; theoretical neuroscience perspectives and empirical evidence on the reciprocal influences between cerebellum, basal ganglia, and cortex in learning and control processes; and data suggesting possible roles of the cerebellum in basal ganglia movement disorders. Although starting from different backgrounds and dealing with different topics, all the contributors agree that viewing the cerebellum, basal ganglia, and cortex as an integrated system enables us to understand the function of these areas in radically different ways. In addition, there is unanimous consensus between the authors that future experimental and computational work is needed to understand the function of cerebellar-basal ganglia circuitry in both motor and non-motor functions. The paper reports the most advanced perspectives on the role of the cerebellum within the cerebello-basal ganglia-thalamo-cortical system and illustrates other elements of consensus as well as disagreements and open questions in the field.
Daniele Caligiore; Giovanni Pezzulo; Gianluca Baldassarre; Andreea C. Bostan; Peter L. Strick; Kenji Doya; Rick C. Helmich; Michiel Dirkx; James Houk; Henrik Jörntell; Angel Lago-Rodriguez; Joseph M. Galea; R. Chris Miall; Traian Popa; Asha Kishore; Paul F. M. J. Verschure; Riccardo Zucca; Ivan Herreros. Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex. The Cerebellum 2016, 16, 203 -229.
AMA StyleDaniele Caligiore, Giovanni Pezzulo, Gianluca Baldassarre, Andreea C. Bostan, Peter L. Strick, Kenji Doya, Rick C. Helmich, Michiel Dirkx, James Houk, Henrik Jörntell, Angel Lago-Rodriguez, Joseph M. Galea, R. Chris Miall, Traian Popa, Asha Kishore, Paul F. M. J. Verschure, Riccardo Zucca, Ivan Herreros. Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex. The Cerebellum. 2016; 16 (1):203-229.
Chicago/Turabian StyleDaniele Caligiore; Giovanni Pezzulo; Gianluca Baldassarre; Andreea C. Bostan; Peter L. Strick; Kenji Doya; Rick C. Helmich; Michiel Dirkx; James Houk; Henrik Jörntell; Angel Lago-Rodriguez; Joseph M. Galea; R. Chris Miall; Traian Popa; Asha Kishore; Paul F. M. J. Verschure; Riccardo Zucca; Ivan Herreros. 2016. "Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex." The Cerebellum 16, no. 1: 203-229.
Three experiments were performed to study observational learning using behavioral, perceptual, and neurophysiological data. Experiment 1 investigated whether observing an execution model, during physical practice of a transitive task that only presented one execution strategy, led to performance improvements compared with physical practice alone. Experiment 2 investigated whether performing an observational learning protocol improves subjects’ action perception. In experiment 3 we evaluated whether the type of practice performed determined the activation of the Mirror Neuron System during action observation. Results showed that, compared with physical practice, observing an execution model during a task that only showed one execution strategy does not provide behavioral benefits. However, an observational learning protocol allows subjects to predict more precisely the outcome of the learned task. Finally, intersperse observation of an execution model with physical practice results in changes of primary motor cortex activity during the observation of the motor pattern previously practiced, whereas modulations in the connectivity between primary and non primary motor areas (PMv-M1; PPC-M1) were not affected by the practice protocol performed by the observer.
Ángel Lago Rodríguez; Virginia Lopez-Alonso; Miguel Fernandez-Del-Olmo. Mirror neuron system and observational learning: Behavioral and neurophysiological evidence. Behavioural Brain Research 2013, 248, 104 -113.
AMA StyleÁngel Lago Rodríguez, Virginia Lopez-Alonso, Miguel Fernandez-Del-Olmo. Mirror neuron system and observational learning: Behavioral and neurophysiological evidence. Behavioural Brain Research. 2013; 248 ():104-113.
Chicago/Turabian StyleÁngel Lago Rodríguez; Virginia Lopez-Alonso; Miguel Fernandez-Del-Olmo. 2013. "Mirror neuron system and observational learning: Behavioral and neurophysiological evidence." Behavioural Brain Research 248, no. : 104-113.