Corrada Geraci

Dr. Corrada Geraci

Istituto di Chimica Biomolecolare - Consiglio Nazionale delle Ricerche Italy
orcid

Research Focus & Metrics

Academic Career Length

40Years (1987-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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27 February 2004 in The Journal of Organic Chemistry
Verified
Journal Article
Closed access
MFMario C. Foti
Mario C. Foti
CDCarmelo Daquino
Carmelo Daquino
Corrada GeraciCorrada Geraci
Corrada Geraci

1 December 2018 in Food Chemistry
Verified
Journal Article
Closed access
GGGiuseppe Granata
Giuseppe Granata
Stefano StracquadanioStefano Stracquadanio
Stefano Stracquadanio
MLMarco Leonardi
Marco Leonardi
Edoardo NapoliEdoardo Napoli
Edoardo Napoli
GCGrazia Maria Letizia Consoli
Grazia Maria Letizia Consoli
Corrada GeraciCorrada Geraci
Corrada Geraci

2 July 2021 in Molecules
Verified
Journal Article
Open access
PDF file
GGGiuseppe Granata
Giuseppe Granata
Stefano StracquadanioStefano Stracquadanio
Stefano Stracquadanio
MLMarco Leonardi
Marco Leonardi
Edoardo NapoliEdoardo Napoli
Edoardo Napoli
Graziella MalandrinoGraziella Malandrino
Graziella Malandrino
Corrada GeraciCorrada Geraci
Corrada Geraci
The use of natural compounds with biocidal activity to fight the growth of bacteria responsible for foodborne illness is one of the main research challenges in the food sector. This study reports the preparation and physicochemical characterization of chitosan nanoparticles loaded with Thymus capitatus (Th-CNPs) and Origanum vulgare (Or-CNPs) essential oils. The nanosystems were obtained by ionotropic gelation technique with high encapsulation efficiency (80–83%) and loading capacity (26–27%). Nanoparticles showed a spherical shape, bimodal particle size distribution, and good stability (zeta potential values > 40 mV). The treatment of the nanosuspensions at different temperatures (4 and 40 °C) and storage times (7, 15, 21, and 30 days) did not affect their physicochemical parameters and highlights their reservoir ability for essential oils also under stressful conditions. Both Or-CNPs and Th-CNPs exhibited an enhanced bactericidal activity against foodborne pathogens (S. aureus, E. coli, L. monocytogenes) than pure essential oils. These ecofriendly nanosystems could represent a valid alternative to synthetic preservatives and be of interest for health and food safety.

11 May 2012 in The EMBO Journal
Verified
Journal Article
Open access
PDF file
MGMonica Giannotta
Monica Giannotta
CRCarmen Ruggiero
Carmen Ruggiero
MGMauro Grossi
Mauro Grossi
JCJorge Cancino
Jorge Cancino
MCMirco Capitani
Mirco Capitani
Michele SalleseMichele Sallese
Michele Sallese
Membrane trafficking involves large fluxes of cargo and membrane across separate compartments. These fluxes must be regulated by control systems to maintain homoeostasis. While control systems for other key functions such as protein folding or the cell cycle are well known, the mechanisms that control secretory transport are poorly understood. We have previously described a signalling circuit operating at the Golgi complex that regulates intra‐Golgi trafficking and is initiated by the KDEL receptor (KDEL‐R), a protein previously known to mediate protein recycling from the Golgi to the endoplasmic reticulum (ER). Here, we investigated the KDEL‐R signalling mechanism. We show that the KDEL‐R is predicted to fold like a G‐protein‐coupled receptor (GPCR), and that it binds and activates the heterotrimeric signalling G‐protein Gαq/11 which, in turn, regulates transport through the Golgi complex. These findings reveal an unexpected GPCR‐like mode of action of the KDEL‐R and shed light on a core molecular control mechanism of intra‐Golgi traffic.

1 October 2020 in Food and Chemical Toxicology
Verified
Journal Article
Closed access
RARosanna Avola
Rosanna Avola
GGGiuseppe Granata
Giuseppe Granata
Corrada GeraciCorrada Geraci
Corrada Geraci
Edoardo NapoliEdoardo Napoli
Edoardo Napoli
AGAdriana Carol Eleonora Graziano
Adriana Carol Eleonora Graziano
VCVenera Cardile
Venera Cardile

23 February 2008 in Bioconjugate Chemistry
Verified
Journal Article
Closed access
Corrada GeraciCorrada Geraci
Corrada Geraci
GCGrazia M. L. Consoli
Grazia M. L. Consoli
EGEva Galante
Eva Galante
EBEnnio Bousquet
Ennio Bousquet
MPMaria Pappalardo
Maria Pappalardo
ASAngelo Spadaro
Angelo Spadaro