The health implications of PM_2.5 in the tropical region of Southeast Asia (SEA) are significant as PM_2.5 can pose serious health concerns. PM_2.5 concentration and sources here are strongly influenced by changes in the monsoon regime from the south-west quadrant to the north-east quadrant in the region. In this work, PM_2.5 samples were collected at a semi-urban area using a high-volume air sampler at different seasons on 24 h basis. Analysis of trace elements and water-soluble ions was performed using inductively coupled plasma mass spectroscopy (ICP-MS) and ion chromatography (IC), respectively. Apportionment analysis of PM_2.5 was carried out using the United States Environmental Protection Agency (US EPA) positive matrix factorization (PMF) 5.0 and a mass closure model. We quantitatively characterized the health risks posed to human populations through the inhalation of selected heavy metals in PM_2.5. 48 % of the samples collected exceeded the World Health Organization (WHO) 24 h PM_2.5 guideline but only 19 % of the samples exceeded 24 h US EPA National Ambient Air Quality Standard (NAAQS). The PM_2.5 concentration was slightly higher during the north-east monsoon compared to south-west monsoon. The main trace metals identified were As, Pb, Cd, Ni, Mn, V, and Cr while the main ions were SO₄²⁻, NO₃⁻, NH₄⁺, and Na. The mass closure model identified four major sources of PM_2.5 that account for 55 % of total mass balance. The four sources are mineral matter (MIN) (35 %), secondary inorganic aerosol (SIA) (11 %), sea salt (SS) (7 %), and trace elements (TE) (2 %). PMF 5.0 elucidated five potential sources: motor vehicle emissions coupled with biomass burning (31 %) were the most dominant, followed by marine/sulfate aerosol (20 %), coal burning (19 %), nitrate aerosol (17 %), and mineral/road dust (13 %). The hazard quotient (HQ) for four selected metals (Pb, As, Cd, and Ni) in PM_2.5 mass was highest in PM_2.5 mass from the coal burning source and least in PM_2.5 mass originating from the mineral/road dust source. The main carcinogenic heavy metal of concern to health at the current location was As; the other heavy metals (Ni, Pb, and Cd) did not pose a significant cancer risk in PM_2.5 mass concentration. Overall, the associated lifetime cancer risk posed by the exposure of hazardous metals in PM_2.5 is 3–4 per 1 000 000 people at this location.