The situation of health-care waste in the Gaza Strip was threatening the environment and the public health due to the absence of appropriate health-care waste (HCW) handling, treatment, and disposal. In 2016, the total amount of HCW generated was estimated about 7199 kg day⁻¹. Around 20% of the wastes was infectious, and the on-site segregation was done only for sharps in most health care facilities, while other infectious wastes were comingled with noninfectious normal wastes. In 2017, a new strategy for the health-care waste management (HCWM) was adopted. The strategy stated the necessity to segregate the HCW into three categories at the generation source to sharps, infectious wastes, and noninfectious wastes. The strategy was implemented over 40 clinics. The proper on-site segregation of the infectious and sharps showed that 2.4 kg day⁻¹ and 0.7 kg day⁻¹ of wastes is generated from UNRWA and Ministry of Health (MOH) clinics, respectively. This generation quantity accounts for a rate of 11 g per outpatient at UNRWA clinics and a ratio of 9.5 g per outpatient at MOH clinics. These quantities account for 33% and 54% of the total waste from UNRWA and governmental clinics in South and Middle Gaza.