Androgenic alopecia (AGA) is the most common type of progressive hair loss in man. The search for reliable predictors of the conservative treatment’s effectiveness is an urgent problem today. Forty-eight patients with AGA, stages I–IV by the Norwood–Hamilton scale, were treated for 4 months with 5% topical minoxidil joints with corrections for trace element and vitamin imbalances. In most cases, the positive therapy’s effect was shown in the parietal but not in the occipital area, whereas that effect was observed in others. The attempts to associate the therapy’s effectiveness with initially defined genetic, hormonal, and metabolic parameters showed the absence of differences between groups with positive and negative outcomes. Among the studied nutrient parameters (Zn, Cu, Mg, Ca, Fe, and Se, as well as vitamins B12, E, D, and folic acid), differences between these groups was shown in zinc content only. The starting point from a zinc plasma level above 10 µmol/L likely provides the success of the subsequent conservative therapy and correlates with an increase in the hair density and diameter in the parietal area. The integral predictive value of the Zn plasma level was assessed as 72.3% (positive predictive value: −88%; and negative predictive value: −55%).

Background: Among pathological hair loss conditions in men the androgenic alopecia (L64 according to ICD-10) has been the most common diagnosed. However, the reasons of the occurrence and development of the disease remain incompletely clarified, that determines the difficulties of personalized therapy. Aims: To analyze both genetic and non-genetic factors involved in the pathogenesis of androgenic alopecia in men, and to create personalized multifactorial model for description of individual causes of the disease. Materials and methods: The genetic predisposition to androgenic alopecia was estimated by the set of SNP rs929626, rs5919324, rs1998076, rs12565727 and rs756853, analyzed by mini-sequencing. The non-genetic factors included: hormones and metabolic markers, trace elements, and vitamins. Two-stage model creation of androgenic alopecia occurrence and development was carried out using a neural network (for genetic factors) followed by step-by-step linear discriminate analysis (for non-genetic factors). Results: The case-control study included 50 men revealing IIV stages of androgenic alopecia (according to Norwood-Hamilton classification) and 25 healthy volunteers relevant in their age and origin. The analysis of each SNP separately did not show significant differences between these groups, while SNP joint consideration in neural network model made it possible to assess the genetic predisposition to androgenic alopecia, as well as to divide the low and high genetic risk subgroups. A large number of significant non-genetic factors, including elevated levels of dihydrotestosterone, 17-OH-progesterone, insulin, and deficiency of Mg, Cu, Zn, Se, vitamins D, E, folic acid was shown in low genetic risk subgroup. In turn, in the high genetic risk subgroup the set of significant non-genetic factors was limited to metabolic and micronutrient disorders only. These data were used for the multifactorial model showing 81.285.1% accuracy being the most effective in early (III) stages of androgenic alopecia. Conclusions: The different influence of non-genetic factors in patients with low and high genetic risk of androgenic alopecia has been revealed. The integral factors consideration in the proposed two-stage multifactorial model identifies individual causes of the disease and gives the chance for the development of personalized therapy of androgenic alopecia in men.

The incidence of basal cell skin cancer is increasing worldwide. The initiation and progression of basal cell skin cancer is due to the interaction of environmental factors and the patient's genetic characteristics. Aberrant activation of the transmission of the Hedgehog signaling pathway is the main pathogenetic pathway of carcinogenesis. Since basal cell skin cancer is manifested by significant variability of morphological structure, aggressiveness and response to treatment, the disclosure of the molecular genetics of pathogenesis will become the basis for developing new approaches and increasing the effectiveness of treatment, as well as overcoming tumor resistance to treatment. To search for the necessary literature, the PubMed, MedLine, Web of Science and RSCI databases were used.

Uncovering the molecular mechanisms of the rosacea pathogenesis and treatment are still of great importance. The review encompasses the modern knowledge of rosacea classification, characterization of the severity of the course of the subtypes, and pathogenesis features. Recent methods of rosacea treatment are presented, including the use of botulinum neuroprotein for the correction of the erythematous-telangiectatic subtype of the dermatosis. The relevance of this problem is due to the chronic course of the disease and the peculiarity of the localization of rosacea manifestations that leads to a traumatic effect and often causes social exclusion of patients. The rise of the rosacea incidences, along with other reasons like characteristics of the course of dermatosis, accompanied by frequent long-term relapses, is due to the resistance to generally accepted methods of drug therapy, often resulting in shortened clinical remission. All the factors lead to decreasing of patients life quality that require the search for effective therapy approaches. Among modern rosacea therapy, the application of botulinum neuroprotein is widely used; however, the clinical studies confirming the effectiveness of this technique are not presented enough.

Basal cell carcinoma is the most common nonmelanoma skin cancer. It originates from undifferentiated cells in the basal cell layer of the epidermis or from the outer root sheath of the hair follicle. The most important factor in development of basalioma is ultraviolet radiation. Surgery is considered the gold standard of treatment for basal cell cancer. However, nonsurgical options are available for individuals who are unsuitable for surgery. The purpose of this review is to summarize the efficacy and indications of alternative, nonsurgical treatments that can be used in the management of basal cell cancer Effective nonsurgical treatments include destructive methods (eg, curettage and electrodessication, cryosurgery, laser), photodynamic therapy, topical medications, hedgehog pathway inhibitors. Nonsurgical therapeutic alternatives are safe and effective for the treatment of BCC. Factors such as tumor location, size, and histopathological subtype should be taken into consideration when selecting optimal treatment, cosmetic results and patient preference should be considered too. To search for the necessary literature, the PubMed, MedLine, Web of Science and RSCI databases were used.

BACKGROUND: diagnosis and treatment of androgenetic alopecia in male patients is a topical issue in modern dermatology, this is due to the high prevalence of this disease in the population, the complexity of the therapy. In most cases, the pathogenesis of this disease is associated with genetic factors, not paying attention to the totality of non-genetic factors that affect the occurrence and development of this disease in male patients. AIM: to study the pathogenetic mechanisms of the occurrence and development of androgenic alopecia in men on the basis of a comprehensive account of genetic, hormonal and metabolic factors. MATERIAL AND METHODS: Genetic predisposition to androgenic alopecia in male patients was evaluated by the method of minisequencing, evaluation of nongenetic factors ― using validated evaluation methods. Further finalizing of the research results was carried out using a neural network and step-by-step linear discriminate analysis. RESULTS: The study included 50 male patients with a verified diagnosis of Androgenic alopecia, stages of the disease from I to IV on the Norwood-Hamilton scale, and 25 volunteers corresponding by age and nationality. The study of nucleotide polymorphisms made it possible to assess the potentially low and high level of genetic risk of this disease. The initial zinc level turned out to be significant for assessing the prognosis of the effectiveness of disease therapy. Mono- or polydeficiency of zinc, copper, magnesium, selenium, vitamins D, B12, E, folic acid play a significant role in the occurrence and development of the disease. CONCLUSIONS: The results of the study show the different role of genetic and non-genetic factors in the occurrence and development of androgenic alopecia in male patients.