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Dr. Nobuo Kanazawa
Department of Dermatology, Wakayama Medical University, Wakayama, 641-0012, Japan

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0 Atopic Dermatitis
0 skin barrier
0 hereditary diseases
0 Autoinflammatory diseases
0 Urticaria

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Autoinflammatory diseases
Atopic Dermatitis
hereditary diseases
Urticaria

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Original article
Published: 02 July 2021 in JID Innovations
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We previously generated a transgenic mouse line expressing skin-specific interleukin (IL)-33 (IL33tg mice) and demonstrated that IL-33 elicits group 2 innate lymphoid cell (ILC2)-dependent atopic dermatitis-like skin inflammation. ILC2s are believed to be tissue-resident cells under steady-state conditions, but the dynamics of ILC2 migration are not fully understood. We sorted ILC2s from the skin and draining lymph nodes (dLNs) of IL33tg mice and analyzed their transcriptomes using the single-cell RNA-sequencing technique, which revealed that the skin ILC2s had split into two clusters: "circulating ILC2" and "skin-resident ILC2." The circulating ILC2s expressed H2-related major histocompatibility complex class II genes. Conversely, the skin-resident ILC2s demonstrated increased expression of the ICOS, IL-5, and IL-13 genes. Next, we tracked ILC2 migration using IL33tg–Kikume Green-Red (KikGR) mice. Exposing the IL33tg–KikGR mice's inflamed skin to violet light allowed us to label the circulating ILC2s in their skin and track the ILC2 migration from the skin to the dLNs. Cutaneous local innate responses could transition to systemic type 2 responses by migrating the activated ILC2s from the skin into the dLN. Conversely, the skin-resident ILC2s produced a large number of cytokines. Thus, the skin ILC2s turned out to be a heterogeneous cell population.

ACS Style

Minori Nakatani-Kusakabe; Koubun Yasuda; Michio Tomura; Makoto Nagai; Kiyofumi Yamanishi; Etsushi Kuroda; Nobuo Kanazawa; Yasutomo Imai. Monitoring Cellular Movement with Photoconvertible Fluorescent Protein and Single-Cell RNA Sequencing Reveals Cutaneous Group 2 Innate Lymphoid Cell Subtypes, Circulating ILC2 and Skin-Resident ILC2. JID Innovations 2021, 1, 1 .

AMA Style

Minori Nakatani-Kusakabe, Koubun Yasuda, Michio Tomura, Makoto Nagai, Kiyofumi Yamanishi, Etsushi Kuroda, Nobuo Kanazawa, Yasutomo Imai. Monitoring Cellular Movement with Photoconvertible Fluorescent Protein and Single-Cell RNA Sequencing Reveals Cutaneous Group 2 Innate Lymphoid Cell Subtypes, Circulating ILC2 and Skin-Resident ILC2. JID Innovations. 2021; 1 (3):1.

Chicago/Turabian Style

Minori Nakatani-Kusakabe; Koubun Yasuda; Michio Tomura; Makoto Nagai; Kiyofumi Yamanishi; Etsushi Kuroda; Nobuo Kanazawa; Yasutomo Imai. 2021. "Monitoring Cellular Movement with Photoconvertible Fluorescent Protein and Single-Cell RNA Sequencing Reveals Cutaneous Group 2 Innate Lymphoid Cell Subtypes, Circulating ILC2 and Skin-Resident ILC2." JID Innovations 1, no. 3: 1.

Concise communication
Published: 22 June 2021 in The Journal of Dermatology
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Atopic dermatitis (AD) is the most common inflammatory skin disease affecting people of all age groups worldwide. To our knowledge, there are currently no studies estimating the effectiveness of tacrolimus ointment and dupilumab as a combination therapy for AD. Thus, here we describe the effectiveness and safety of tacrolimus ointment in combination with dupilumab for facial rashes in patients with AD. Overall, we included 109 patients who newly received dupilumab from April 2018 to July 2020 in the Dermatology Department of Hyogo College of Medicine Hospital. Of them, 60 patients were treated with tacrolimus ointment. Specifically, of the 60 patients, 40 were treated with dupilumab in combination with tacrolimus ointment and topical steroids, whereas the remaining 20 were prescribed tacrolimus ointment alone and were further analyzed. The analysis showed that the combination does not cause serious side-effects at high frequency. The patients showed rapid improvement of facial dermatitis along with systemic dermatitis, and the rate of improvement of head/neck Eczema Area and Severity Index (EASI) score significantly correlated with the rate of improvement of overall EASI score. In addition, there was no complication of herpes simplex observed in these 20 patients. Thus, tacrolimus ointment combined with dupilumab is an effective and safe treatment option for facial AD.

ACS Style

Masako Matsutani; Yasutomo Imai; Yukako Inoue; Minori Nakatani‐Kusakabe; Masaru Natsuaki; Kiyofumi Yamanishi; Nobuo Kanazawa. Effectiveness and safety of tacrolimus ointment combined with dupilumab for patients with atopic dermatitis in real‐world clinical practice. The Journal of Dermatology 2021, 1 .

AMA Style

Masako Matsutani, Yasutomo Imai, Yukako Inoue, Minori Nakatani‐Kusakabe, Masaru Natsuaki, Kiyofumi Yamanishi, Nobuo Kanazawa. Effectiveness and safety of tacrolimus ointment combined with dupilumab for patients with atopic dermatitis in real‐world clinical practice. The Journal of Dermatology. 2021; ():1.

Chicago/Turabian Style

Masako Matsutani; Yasutomo Imai; Yukako Inoue; Minori Nakatani‐Kusakabe; Masaru Natsuaki; Kiyofumi Yamanishi; Nobuo Kanazawa. 2021. "Effectiveness and safety of tacrolimus ointment combined with dupilumab for patients with atopic dermatitis in real‐world clinical practice." The Journal of Dermatology , no. : 1.

Guidelines
Published: 13 June 2021 in The Journal of Dermatology
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Palmoplantar keratoderma (PPK) is a collective term for keratinizing disorders in which the main clinical symptom is hyperkeratosis on the palms and soles. To establish the first Japanese guidelines approved by the Japanese Dermatological Association for the management of PPKs, the Committee for the Management of PPKs was founded as part of the Study Group for Rare Intractable Diseases. These guidelines aim to provide current information for the management of PPKs in Japan. Based on evidence, they summarize the clinical manifestations, pathophysiologies, diagnostic criteria, disease severity determination criteria, treatment, and treatment recommendations. Because of the rarity of PPKs, there are only few clinical studies with a high degree of evidence. Therefore, several parts of these guidelines were established based on the opinions of the committee. To further optimize the guidelines, periodic revision in line with new evidence is necessary.

ACS Style

Kozo Yoneda; Akiharu Kubo; Toshifumi Nomura; Akemi Ishida‐Yamamoto; Yasushi Suga; Masashi Akiyama; Nobuo Kanazawa; Takashi Hashimoto; Committee on Guidelines for the Management of PPKs. Japanese guidelines for the management of palmoplantar keratoderma. The Journal of Dermatology 2021, 1 .

AMA Style

Kozo Yoneda, Akiharu Kubo, Toshifumi Nomura, Akemi Ishida‐Yamamoto, Yasushi Suga, Masashi Akiyama, Nobuo Kanazawa, Takashi Hashimoto, Committee on Guidelines for the Management of PPKs. Japanese guidelines for the management of palmoplantar keratoderma. The Journal of Dermatology. 2021; ():1.

Chicago/Turabian Style

Kozo Yoneda; Akiharu Kubo; Toshifumi Nomura; Akemi Ishida‐Yamamoto; Yasushi Suga; Masashi Akiyama; Nobuo Kanazawa; Takashi Hashimoto; Committee on Guidelines for the Management of PPKs. 2021. "Japanese guidelines for the management of palmoplantar keratoderma." The Journal of Dermatology , no. : 1.

Letter to the editor
Published: 25 May 2021 in The Journal of Dermatology
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ACS Style

Erina Fukumura; Kozo Nakai; Sayaka Togo; Sadao Tokimasa; Nobuo Kanazawa; Daisuke Tsuruta. Case of Muckle–Wells syndrome with obesity. The Journal of Dermatology 2021, 1 .

AMA Style

Erina Fukumura, Kozo Nakai, Sayaka Togo, Sadao Tokimasa, Nobuo Kanazawa, Daisuke Tsuruta. Case of Muckle–Wells syndrome with obesity. The Journal of Dermatology. 2021; ():1.

Chicago/Turabian Style

Erina Fukumura; Kozo Nakai; Sayaka Togo; Sadao Tokimasa; Nobuo Kanazawa; Daisuke Tsuruta. 2021. "Case of Muckle–Wells syndrome with obesity." The Journal of Dermatology , no. : 1.

Journal article
Published: 25 April 2021 in Children
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Objectives: Blau syndrome is a distinct class of autoinflammatory syndrome presenting with early-onset systemic granulomatosis. Blau syndrome-causing NOD2 mutations located in the central nucleotide-oligomerization domain induce ligand-independent basal NF-κB activation in an in vitro reporter assay. However, the precise role of this signaling on granuloma formation has not yet been clarified. Methods: Blau syndrome-causing NOD2 mutations were introduced into human monocytic THP-1 cells, and their morphological and molecular changes from parental cells were analyzed. Identified molecules with altered expression were examined in the patient’s lesional skin by immunostaining. Results: Although the production of proinflammatory cytokines was not altered without stimulation, mutant NOD2-expressing THP-1 cells attached persistently to the culture plate after stimulation with phorbol myristate acetate. Sustained surface ICAM-1 expression was observed in association with this phenomenon, but neither persistent ICAM-1 mRNA expression nor impaired ADAM17 mRNA expression was revealed. However, the transient induction of PDGF-B mRNA expression was specifically observed in stimulated THP-1 derivatives. In the granulomatous skin lesion of a Blau syndrome patient, ICAM-1 and PDGF-B were positively immunostained in NOD2-expressing giant cells. Conclusions: Sustained surface ICAM-1 expression and transient PDGF-B production by newly differentiating macrophages harboring mutant NOD2 might play a role in granuloma formation in Blau syndrome.

ACS Style

Mizuho Nishiyama; Hong-Jin Li; Ikuo Okafuji; Akihiko Fujisawa; Mizue Ehara; Naotomo Kambe; Fukumi Furukawa; Nobuo Kanazawa. Sustained Surface ICAM-1 Expression and Transient PDGF-B Production by Phorbol Myristate Acetate-Activated THP-1 Cells Harboring Blau Syndrome-Associated NOD2 Mutations. Children 2021, 8, 335 .

AMA Style

Mizuho Nishiyama, Hong-Jin Li, Ikuo Okafuji, Akihiko Fujisawa, Mizue Ehara, Naotomo Kambe, Fukumi Furukawa, Nobuo Kanazawa. Sustained Surface ICAM-1 Expression and Transient PDGF-B Production by Phorbol Myristate Acetate-Activated THP-1 Cells Harboring Blau Syndrome-Associated NOD2 Mutations. Children. 2021; 8 (5):335.

Chicago/Turabian Style

Mizuho Nishiyama; Hong-Jin Li; Ikuo Okafuji; Akihiko Fujisawa; Mizue Ehara; Naotomo Kambe; Fukumi Furukawa; Nobuo Kanazawa. 2021. "Sustained Surface ICAM-1 Expression and Transient PDGF-B Production by Phorbol Myristate Acetate-Activated THP-1 Cells Harboring Blau Syndrome-Associated NOD2 Mutations." Children 8, no. 5: 335.

Letter to the editor
Published: 21 March 2021 in The Journal of Dermatology
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ACS Style

Hiroki Furukawa; Reina Omura; Kazumitsu Sugiura; Nobuo Kanazawa; Norimitsu Inoue; Hua Qian; Xiaoguang Li; Daisuke Tsuruta; Takashi Hashimoto. Granular C3 dermatosis‐like immunological manifestation found in a case of acute generalized exanthematous pustulosis: Implication for the mechanism in C3 deposition to the epidermal basement membrane zone. The Journal of Dermatology 2021, 48, 1 .

AMA Style

Hiroki Furukawa, Reina Omura, Kazumitsu Sugiura, Nobuo Kanazawa, Norimitsu Inoue, Hua Qian, Xiaoguang Li, Daisuke Tsuruta, Takashi Hashimoto. Granular C3 dermatosis‐like immunological manifestation found in a case of acute generalized exanthematous pustulosis: Implication for the mechanism in C3 deposition to the epidermal basement membrane zone. The Journal of Dermatology. 2021; 48 (5):1.

Chicago/Turabian Style

Hiroki Furukawa; Reina Omura; Kazumitsu Sugiura; Nobuo Kanazawa; Norimitsu Inoue; Hua Qian; Xiaoguang Li; Daisuke Tsuruta; Takashi Hashimoto. 2021. "Granular C3 dermatosis‐like immunological manifestation found in a case of acute generalized exanthematous pustulosis: Implication for the mechanism in C3 deposition to the epidermal basement membrane zone." The Journal of Dermatology 48, no. 5: 1.

Case report
Published: 06 February 2021 in Children
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We describe a patient who developed multiple granulomatous skin lesions after Bacille de Calmette et Guérin (BCG) vaccination without significant effect by topical corticosteroid, followed by painless cystic tumors on the bilateral knees and hands and inflammatory changes on ophthalmologic examination. A functional mutation in NOD2 was detected by a genetic analysis, and he was diagnosed as sporadic Blau syndrome. Since NOD2 acts as a sensor for the BCG component, it is possible that BCG vaccination may trigger granuloma formation in Blau syndrome patients with such genetic background.

ACS Style

Akiko Arakawa; Naotomo Kambe; Ryuta Nishikomori; Akiyo Tanabe; Masamichi Ueda; Chikako Nishigori; Yoshiki Miyachi; Nobuo Kanazawa. NOD2 Mutation-Associated Case with Blau Syndrome Triggered by BCG Vaccination. Children 2021, 8, 117 .

AMA Style

Akiko Arakawa, Naotomo Kambe, Ryuta Nishikomori, Akiyo Tanabe, Masamichi Ueda, Chikako Nishigori, Yoshiki Miyachi, Nobuo Kanazawa. NOD2 Mutation-Associated Case with Blau Syndrome Triggered by BCG Vaccination. Children. 2021; 8 (2):117.

Chicago/Turabian Style

Akiko Arakawa; Naotomo Kambe; Ryuta Nishikomori; Akiyo Tanabe; Masamichi Ueda; Chikako Nishigori; Yoshiki Miyachi; Nobuo Kanazawa. 2021. "NOD2 Mutation-Associated Case with Blau Syndrome Triggered by BCG Vaccination." Children 8, no. 2: 117.

Preprint content
Published: 02 February 2021
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BACKGROUND Defective proteasome activities due to genetic mutations lead to an autoinflammatory disease, termed as proteasome-associated autoinflammatory syndromes (PRAAS). In PRAAS relapsing inflammations and progressive wasting are common, but immunodeficiency has not been reported. METHODS We studied two unrelated Japanese infants with PRAAS-like manifestations. We have also generated and analyzed the mice carrying the candidate mutation found in the patients. RESULTS Both patients showed neonatal-onset skin rash, myositis and basal ganglia calcification, similar to PRAAS patients. Meanwhile, they manifested distinct phenotypes, including pulmonary hypertension and immunodeficiency without lipoatrophy. We identified a novel de novo heterozygous missense mutation, G156D, in a proteasome subunit gene, PSMB9, encoding β1i, in the two patients. Maturation and activity of the immunoproteasome were impaired, but ubiquitin accumulation was hardly detected not only in patient-derived cells and samples but also in Psmb9 G156D/+ mice. As an immunodeficient phenotype, one patient showed decrease of B cells and increase of monocytes, while the other patient showed decrease of CD8 T cells. The proteasome defects and immunodeficient phenotypes were recapitulated in Psmb9 G156D/+ mice. CONCLUSIONS The PSMB9 G156D is a unique mutation in proteasome subunits in causing defects by its heterozygosity, affecting two β rings interaction and leading to immunodeficiency. The mutant mice are the first mice model for analyzing proteasome dysfunctions in PRAAS. We here propose the term, proteasome-associated autoinflammation and immunodeficiency disease (PRAID), as an umbrella name for our cases, PRAAS with immunodeficiency, as well as PRAAS described so far.

ACS Style

Nobuo Kanazawa; Hiroaki Hemmi; Noriko Kinjo; Hidenori Ohnishi; Jun Hamazaki; Hiroyuki Mishima; Akira Kinoshita; Tsunehiro Mizushima; Satoru Hamada; Kazuya Hamada; Norio Kawamoto; Saori Kadowaki; Yoshitaka Honda; Kazushi Izawa; Ryuta Nishikomori; Miyuki Tsumura; Yusuke Yamashita; Shinobu Tamura; Takashi Orimo; Toshiya Ozasa; Takashi Kato; Izumi Sasaki; Yuri Fukuda-Ohta; Naoko Wakaki-Nishiyama; Yutaka Inaba; Kayo Kunimoto; Satoshi Okada; Takeshi Taketani; Koichi Nakanishi; Shigeo Murata; Koh-Ichiro Yoshiura; Tsuneyasu Kaisho. Neonatal-onset autoinflammation and immunodeficiency caused by heterozygous missense mutation of the proteasome subunit β-type 9. 2021, 1 .

AMA Style

Nobuo Kanazawa, Hiroaki Hemmi, Noriko Kinjo, Hidenori Ohnishi, Jun Hamazaki, Hiroyuki Mishima, Akira Kinoshita, Tsunehiro Mizushima, Satoru Hamada, Kazuya Hamada, Norio Kawamoto, Saori Kadowaki, Yoshitaka Honda, Kazushi Izawa, Ryuta Nishikomori, Miyuki Tsumura, Yusuke Yamashita, Shinobu Tamura, Takashi Orimo, Toshiya Ozasa, Takashi Kato, Izumi Sasaki, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Yutaka Inaba, Kayo Kunimoto, Satoshi Okada, Takeshi Taketani, Koichi Nakanishi, Shigeo Murata, Koh-Ichiro Yoshiura, Tsuneyasu Kaisho. Neonatal-onset autoinflammation and immunodeficiency caused by heterozygous missense mutation of the proteasome subunit β-type 9. . 2021; ():1.

Chicago/Turabian Style

Nobuo Kanazawa; Hiroaki Hemmi; Noriko Kinjo; Hidenori Ohnishi; Jun Hamazaki; Hiroyuki Mishima; Akira Kinoshita; Tsunehiro Mizushima; Satoru Hamada; Kazuya Hamada; Norio Kawamoto; Saori Kadowaki; Yoshitaka Honda; Kazushi Izawa; Ryuta Nishikomori; Miyuki Tsumura; Yusuke Yamashita; Shinobu Tamura; Takashi Orimo; Toshiya Ozasa; Takashi Kato; Izumi Sasaki; Yuri Fukuda-Ohta; Naoko Wakaki-Nishiyama; Yutaka Inaba; Kayo Kunimoto; Satoshi Okada; Takeshi Taketani; Koichi Nakanishi; Shigeo Murata; Koh-Ichiro Yoshiura; Tsuneyasu Kaisho. 2021. "Neonatal-onset autoinflammation and immunodeficiency caused by heterozygous missense mutation of the proteasome subunit β-type 9." , no. : 1.

Preprint content
Published: 02 June 2020
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Nakajo-Nishimura syndrome (NNS) is an autoinflammatory disorder caused by a homozygous mutations in PSMB8 gene. The administration of systemic corticosteroids is partially effective, but continuous treatment causes severe side effects. We previously established a pluripotent stem cell (PSC)-derived NNS disease model that reproduces several inflammatory phenotypes including the overproduction of monocyte chemoattractant protein-1 (MCP-1) and interferon gamma-induced protein-10 (IP-10). Here we performed high-throughput compound screening (HTS) using this PSC-derived NNS model to find potential therapeutic candidates and identified CUDC-907 as an effective inhibitor of the release of MCP-1 and IP-10. CUDC-907 did not induce cell death within therapeutic concentrations and was also effective on primary patient cells. Further analysis indicated that the inhibitory effect was post-transcriptional. These findings suggest that HTS with PSC-derived disease models is useful for finding drug candidates for autoinflammatory diseases.

ACS Style

Naoya Kase; Madoka Terashima; Akira Ohta; Akira Niwa; Fumiko Honda-Ozaki; Yuri Kawasaki; Tatsutoshi Nakahata; Nabuo Kanazawa; Megumu Saito. High-throughput Screening with Pluripotent Stem Cells Identifies CUDC-907 as an Effective Compound for Restoring the Proinflammatory Phenotype of Nakajo-Nishimura Syndrome. 2020, 1 .

AMA Style

Naoya Kase, Madoka Terashima, Akira Ohta, Akira Niwa, Fumiko Honda-Ozaki, Yuri Kawasaki, Tatsutoshi Nakahata, Nabuo Kanazawa, Megumu Saito. High-throughput Screening with Pluripotent Stem Cells Identifies CUDC-907 as an Effective Compound for Restoring the Proinflammatory Phenotype of Nakajo-Nishimura Syndrome. . 2020; ():1.

Chicago/Turabian Style

Naoya Kase; Madoka Terashima; Akira Ohta; Akira Niwa; Fumiko Honda-Ozaki; Yuri Kawasaki; Tatsutoshi Nakahata; Nabuo Kanazawa; Megumu Saito. 2020. "High-throughput Screening with Pluripotent Stem Cells Identifies CUDC-907 as an Effective Compound for Restoring the Proinflammatory Phenotype of Nakajo-Nishimura Syndrome." , no. : 1.

Journal article
Published: 01 November 2019 in Journal of Allergy and Clinical Immunology
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Food allergy is a growing health problem worldwide because of its increasing prevalence, life-threatening potential, and shortage of effective preventive treatments. In an outbreak of wheat allergy in Japan, thousands of patients had allergic reactions to wheat after using soap containing hydrolyzed wheat protein (HWP). The aim of the present study was to investigate genetic variation that can contribute to susceptibility to HWP allergy. We conducted a genome-wide association study of HWP allergy in 452 cases and 2700 control subjects using 6.6 million genotyped or imputed single nucleotide polymorphisms. Replication was assessed by genotyping single nucleotide polymorphisms in independent samples comprising 45 patients with HWP allergy and 326 control subjects. Through the genome-wide association study, we identified significant associations with the class II HLA region on 6p21 (P = 2.16 × 10-24 for rs9271588 and P = 2.96 × 10-24 for HLA-DQα1 amino acid position 34) and with the RBFOX1 locus at 16p13 (rs74575857, P = 8.4 × 10-9). The associations were also confirmed in the replication data set. Both amino acid polymorphisms (HLA-DQβ1 amino acid positions 13 and 26) located in the P4 binding pockets on the HLA-DQ molecule achieved the genome-wide significance level (P < 5.0 × 10-8). Our data provide the first demonstration of genetic risk for HWP allergy and show that this genetic risk is mainly represented by multiple combinations of HLA variants.

ACS Style

Emiko Noguchi; Masato Akiyama; Akiko Yagami; Tomomitsu Hirota; Yukinori Okada; Zenichiro Kato; Reiko Kishikawa; Yuma Fukutomi; Michihiro Hide; Eishin Morita; Michiko Aihara; Makiko Hiragun; Yuko Chinuki; Takahiro Okabe; Akiko Ito; Atsuko Adachi; Atsushi Fukunaga; Yumiko Kubota; Toshiyuki Aoki; Youko Aoki; Kazue Nishioka; Tetsuya Adachi; Nobuo Kanazawa; Hitoshi Miyazawa; Hiroyuki Sakai; Takehito Kozuka; Hideo Kitamura; Hideo Hashizume; Chiharu Kanegane; Koji Masuda; Kumiya Sugiyama; Reiko Tokuda; Junichi Furuta; Ikkou Higashimoto; Atsuko Kato; Mariko Seishima; Akihiko Tajiri; Atsuko Tomura; Hiroko Taniguchi; Hiroto Kojima; Hidenori Tanaka; Aiko Sakai; Wataru Morii; Masashi Nakamura; Yoichiro Kamatani; Atsushi Takahashi; Michiaki Kubo; Mayumi Tamari; Hirohisa Saito; Kayoko Matsunaga. HLA-DQ and RBFOX1 as susceptibility genes for an outbreak of hydrolyzed wheat allergy. Journal of Allergy and Clinical Immunology 2019, 144, 1354 -1363.

AMA Style

Emiko Noguchi, Masato Akiyama, Akiko Yagami, Tomomitsu Hirota, Yukinori Okada, Zenichiro Kato, Reiko Kishikawa, Yuma Fukutomi, Michihiro Hide, Eishin Morita, Michiko Aihara, Makiko Hiragun, Yuko Chinuki, Takahiro Okabe, Akiko Ito, Atsuko Adachi, Atsushi Fukunaga, Yumiko Kubota, Toshiyuki Aoki, Youko Aoki, Kazue Nishioka, Tetsuya Adachi, Nobuo Kanazawa, Hitoshi Miyazawa, Hiroyuki Sakai, Takehito Kozuka, Hideo Kitamura, Hideo Hashizume, Chiharu Kanegane, Koji Masuda, Kumiya Sugiyama, Reiko Tokuda, Junichi Furuta, Ikkou Higashimoto, Atsuko Kato, Mariko Seishima, Akihiko Tajiri, Atsuko Tomura, Hiroko Taniguchi, Hiroto Kojima, Hidenori Tanaka, Aiko Sakai, Wataru Morii, Masashi Nakamura, Yoichiro Kamatani, Atsushi Takahashi, Michiaki Kubo, Mayumi Tamari, Hirohisa Saito, Kayoko Matsunaga. HLA-DQ and RBFOX1 as susceptibility genes for an outbreak of hydrolyzed wheat allergy. Journal of Allergy and Clinical Immunology. 2019; 144 (5):1354-1363.

Chicago/Turabian Style

Emiko Noguchi; Masato Akiyama; Akiko Yagami; Tomomitsu Hirota; Yukinori Okada; Zenichiro Kato; Reiko Kishikawa; Yuma Fukutomi; Michihiro Hide; Eishin Morita; Michiko Aihara; Makiko Hiragun; Yuko Chinuki; Takahiro Okabe; Akiko Ito; Atsuko Adachi; Atsushi Fukunaga; Yumiko Kubota; Toshiyuki Aoki; Youko Aoki; Kazue Nishioka; Tetsuya Adachi; Nobuo Kanazawa; Hitoshi Miyazawa; Hiroyuki Sakai; Takehito Kozuka; Hideo Kitamura; Hideo Hashizume; Chiharu Kanegane; Koji Masuda; Kumiya Sugiyama; Reiko Tokuda; Junichi Furuta; Ikkou Higashimoto; Atsuko Kato; Mariko Seishima; Akihiko Tajiri; Atsuko Tomura; Hiroko Taniguchi; Hiroto Kojima; Hidenori Tanaka; Aiko Sakai; Wataru Morii; Masashi Nakamura; Yoichiro Kamatani; Atsushi Takahashi; Michiaki Kubo; Mayumi Tamari; Hirohisa Saito; Kayoko Matsunaga. 2019. "HLA-DQ and RBFOX1 as susceptibility genes for an outbreak of hydrolyzed wheat allergy." Journal of Allergy and Clinical Immunology 144, no. 5: 1354-1363.

Journal article
Published: 18 September 2019 in Allergology International
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Ginger is considered to be good for health and widely used as a spice or antidote. While beneficial effects of ginger for prevention and amelioration of allergic diseases have been reported,1x1Park, G., Oh, D.S., Lee, M.G., Lee, C.E., and Kim, Y.U. 6-Shogaol, an active compound of ginger, alleviates allergic dermatitis-like skin lesions via cytokine inhibition by activating the Nrf 2 pathway. Toxicol Appl Pharmacol. 2016; 310: 51–59Google ScholarSee all References,2x2Kawamoto, Y., Ueno, Y., Nakahashi, E., Obayashi, M., Sugihara, K., Qiao, S. et al. Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation. J Nutr Biochem. 2016; 27: 112–122Google ScholarSee all References ginger allergy is very rare despite its wide usage. A case with ginger-specific immunoglobulin E (IgE) sensitized by the industrial dust from spices was reported back in 1985.3x3van Toorenenbergen, A.W. and Dieges, P.H. Immunoglobulin E antibodies against coriander and other spices. J Allergy Clin Immunol. 1985; 76: 477–481Google ScholarSee all References In 2002, however, a skin prick test (SPT) with ginger was negatively observed in 589 cases of food allergy.4x4Moneret-Vautrin, D.A., Morisset, M., Lemerdy, P., Croizier, A., and Kanny, G. Food allergy and IgE sensitization caused by spices: CICBAA data (based on 589 cases of food allergy). Allerg Immunol (Paris). 2002; 34: 135–140Google ScholarSee all References Recently, some cases with IgE-mediated ginger allergy have been reported and cysteine proteinase GP-I has been detected as a candidate allergen.5x5Gehlhaar, P., González-de-Olano, D., Madrigal-Burgaleta, R., Bartolomé, B., and Pastor-Vargas, C. Allergy to ginger with cysteine proteinase GP-I as the relevant allergen. Ann Allergy Asthma Immunol. 2018; 121: 624–625Google ScholarSee all References,6x6Schmidt, J., Dahl, S., and Sherson, D.L. Allergic rhinoconjunctivitis caused by occupational exposure to ginger. Ugeskr Laeger. 2015; : 177 (in Danish)Google ScholarSee all References,7x7Sato, H., Manki, S., Manki, A., Ishii, T., and Watanabe, H. A case of food-dependent exercise-induced anaphylaxis induced by ginger. Pediatrics Japan. 2018; 59: 453–456 (in Japanese)Google ScholarSee all References Meanwhile, use of herbal medicine is expanding because it is easy to obtain as an over-the-counter drug and considered positively because it is “natural” and mostly harmless. However, frequent application of natural product would rather increase the risk of allergy for any food containing the same product. We report a case of anaphylaxis to ginger induced by taking herbal medicine.

ACS Style

Hisako Okuhira; Yumi Nakatani; Fukumi Furukawa; Nobuo Kanazawa. Anaphylaxis to ginger induced by herbal medicine. Allergology International 2019, 69, 159 -160.

AMA Style

Hisako Okuhira, Yumi Nakatani, Fukumi Furukawa, Nobuo Kanazawa. Anaphylaxis to ginger induced by herbal medicine. Allergology International. 2019; 69 (1):159-160.

Chicago/Turabian Style

Hisako Okuhira; Yumi Nakatani; Fukumi Furukawa; Nobuo Kanazawa. 2019. "Anaphylaxis to ginger induced by herbal medicine." Allergology International 69, no. 1: 159-160.

Journal article
Published: 31 August 2019 in BioScience Trends
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We conducted a study to try to plot the lesions of melanocytic nevus and malignant melanoma on the palm and fingers, and compared them to identify the different distribution pattern of both lesions. Data on 8 patients with melanomas (4 male and 4 female) and 26 patients with melanocytic nevus (6 male and 20 female) of palm and finger pulp who visited Wakayama Medical University Hospital between 1986 and 2018 was retrospectively collected. We found that all of the 8 lesions of melanoma were located on the finger pulps and distal to the 'distal transverse crease' of the palm, and that melanomas were not present proximal to the transverse crease. On the other hand, melanocytic nevus was present in the proximal area to the distal transverse crease of the palm more frequently than melanomas (50.0% vs. 0%), and there was statistically significant difference (p = 0.011 by Fisher's exact probability test). From these observations, our findings may reveal the contribution of mechanical stress to the cause of palmar melanoma, and may facilitate clinical differentiation between malignant melanoma and melanocytic nevus by the localization. Further studies with increased number of patients are needed to validate the finding.

ACS Style

Mana Nishiguchi; Yuki Yamamoto; Tomoyuki Hara; Hisako Okuhira; Yutaka Inaba; Kayo Kunimoto; Naoya Mikita; Chikako Kaminaka; Nobuo Kanazawa; Masatoshi Jinnin. Difference in distribution of malignant melanoma and melanocytic nevus in the palm and finger. BioScience Trends 2019, 13, 361 -363.

AMA Style

Mana Nishiguchi, Yuki Yamamoto, Tomoyuki Hara, Hisako Okuhira, Yutaka Inaba, Kayo Kunimoto, Naoya Mikita, Chikako Kaminaka, Nobuo Kanazawa, Masatoshi Jinnin. Difference in distribution of malignant melanoma and melanocytic nevus in the palm and finger. BioScience Trends. 2019; 13 (4):361-363.

Chicago/Turabian Style

Mana Nishiguchi; Yuki Yamamoto; Tomoyuki Hara; Hisako Okuhira; Yutaka Inaba; Kayo Kunimoto; Naoya Mikita; Chikako Kaminaka; Nobuo Kanazawa; Masatoshi Jinnin. 2019. "Difference in distribution of malignant melanoma and melanocytic nevus in the palm and finger." BioScience Trends 13, no. 4: 361-363.

Journal article
Published: 02 August 2019 in The Journal of Dermatology
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Tomoyuki Hara; Naoya Mikita; Takaharu Ikeda; Yutaka Inaba; Kayo Kunimoto; Chikako Kaminaka; Nobuo Kanazawa; Yuki Yamamoto; Masatoshi Jinnin. Psoriatic arthritis induced by anti‐programmed death 1 antibody pembrolizumab. The Journal of Dermatology 2019, 46, e466 -e467.

AMA Style

Tomoyuki Hara, Naoya Mikita, Takaharu Ikeda, Yutaka Inaba, Kayo Kunimoto, Chikako Kaminaka, Nobuo Kanazawa, Yuki Yamamoto, Masatoshi Jinnin. Psoriatic arthritis induced by anti‐programmed death 1 antibody pembrolizumab. The Journal of Dermatology. 2019; 46 (12):e466-e467.

Chicago/Turabian Style

Tomoyuki Hara; Naoya Mikita; Takaharu Ikeda; Yutaka Inaba; Kayo Kunimoto; Chikako Kaminaka; Nobuo Kanazawa; Yuki Yamamoto; Masatoshi Jinnin. 2019. "Psoriatic arthritis induced by anti‐programmed death 1 antibody pembrolizumab." The Journal of Dermatology 46, no. 12: e466-e467.

Comparative study
Published: 02 August 2019 in The Journal of Dermatology
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Infantile hemangioma is one of the most common tumors in infancy. Delivery may be a clue for the trigger of infantile hemangioma formation in the head and face areas. In this study, we tried to plot localization of infantile hemangioma as well as capillary malformation on the head and face, and compared them to identify their characteristics and risk factors. The distribution of 104 lesions in 100 patients with infantile hemangioma was as follows: 32 lesions on the head, 12 on the forehead, 57 on the cheek and three in the jaw area. We could not find a statistically significant correlation of the distribution with three clinical subtypes (superficial, deep and mixed), sex or size of the lesions. However, the lesions in the jaw or chin areas were significantly less frequent than other areas (P = 0.0008 or 0.03, respectively). This tendency was not found in 40 patients with capillary malformation. Mechanical stress to jaw or chin areas may be less than other areas in normal cephalic delivery. Considering the emergence after birth and age-dependent involution of infantile hemangioma, we speculate that physiological events including perinatal hypoxia or mechanical stress during delivery as the trigger of hemangioma formation. Taken together, our results may reveal the contribution of mechanical stress to the trigger of infantile hemangioma, not capillary malformation, and may facilitate clinical differentiation between the two diseases by their localization. Further studies with an increased number of patients will be necessary to validate the finding.

ACS Style

Ami Kawaguchi; Kayo Kunimoto; Yutaka Inaba; Naoya Mikita; Chikako Kaminaka; Nobuo Kanazawa; Yuki Yamamoto; Nobuyuki Kakimoto; Tomohiro Suenaga; Takashi Takeuchi; Hiroyuki Suzuki; Naoko Baba; Masatoshi Jinnin. Distribution analysis of infantile hemangioma or capillary malformation on the head and face in Japanese patients. The Journal of Dermatology 2019, 46, 849 -852.

AMA Style

Ami Kawaguchi, Kayo Kunimoto, Yutaka Inaba, Naoya Mikita, Chikako Kaminaka, Nobuo Kanazawa, Yuki Yamamoto, Nobuyuki Kakimoto, Tomohiro Suenaga, Takashi Takeuchi, Hiroyuki Suzuki, Naoko Baba, Masatoshi Jinnin. Distribution analysis of infantile hemangioma or capillary malformation on the head and face in Japanese patients. The Journal of Dermatology. 2019; 46 (10):849-852.

Chicago/Turabian Style

Ami Kawaguchi; Kayo Kunimoto; Yutaka Inaba; Naoya Mikita; Chikako Kaminaka; Nobuo Kanazawa; Yuki Yamamoto; Nobuyuki Kakimoto; Tomohiro Suenaga; Takashi Takeuchi; Hiroyuki Suzuki; Naoko Baba; Masatoshi Jinnin. 2019. "Distribution analysis of infantile hemangioma or capillary malformation on the head and face in Japanese patients." The Journal of Dermatology 46, no. 10: 849-852.

Journal article
Published: 21 July 2019 in British Journal of Dermatology
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T. Hashimoto; Nobuo Kanazawa; N. Inoue. Anticomplement therapy in bullous pemphigoid. British Journal of Dermatology 2019, 181, 448 -449.

AMA Style

T. Hashimoto, Nobuo Kanazawa, N. Inoue. Anticomplement therapy in bullous pemphigoid. British Journal of Dermatology. 2019; 181 (3):448-449.

Chicago/Turabian Style

T. Hashimoto; Nobuo Kanazawa; N. Inoue. 2019. "Anticomplement therapy in bullous pemphigoid." British Journal of Dermatology 181, no. 3: 448-449.

Review
Published: 23 May 2019 in Inflammation and Regeneration
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Nakajo-Nishimura syndrome is a proteasome-associated autoinflammatory syndrome with a distinct homozygous mutation in the PSMB8 gene encoding an inducible β5i subunit of the immunoproteasome. Although it is considered that immunoproteasome dysfunction causes cellular stress and contributes to the production of inflammatory cytokines and chemokines, its detailed mechanism is still unknown. On the other hand, hereditary autoinflammatory diseases are considered as a good target for the analyses using induced pluripotent stem cells, whose differentiation systems to the innate immune cells such as neutrophils and monocytes have been established. Therefore, to elucidate the pathogenesis of Nakajo-Nishimura syndrome, we attempted in vitro disease modeling using patient-derived induced pluripotent stem cells. For analyses, isogenic control cells in which the responsible mutation was repaired and another pair of healthy embryonic stem cells and isogenic mutant cells in which the same mutation was introduced had also been prepared with genetic engineering. By comparing a pair of isogenic cells with the wild-type and the mutant PSMB8 gene after differentiation into monocytes and immortalization to synchronize their differentiation stages, the reduction of immunoproteasome enzyme activity and increased cytokine and chemokine production in the mutant cells without stimulation or with interferon-γ plus tumor necrosis factor-α stimulation were observed, and therefore, the autoinflammatory phenotype was successfully reproduced. Decreased cytokine production was observed by the addition of antioxidants as well as inhibitors for Janus kinase and p38-mitogen-activated protein kinase. At the same time, the increased production of reactive oxygen species and phosphorylation of both signal transducers and activator of transcription 1 and p38-mitogen-activated protein kinase were detected without stimulation. Notably, an antioxidant specifically decreased the constitutive phosphorylation of signal transducers and activator of transcription 1. These results indicate the usefulness of a disease modeling using pluripotent stem cell-derived cells in clarification of the pathomechanism and discovery of new therapeutic drugs for Nakajo-Nishimura syndrome and related proteasome-associated autoinflammatory syndromes.

ACS Style

Nobuo Kanazawa; Fumiko Honda-Ozaki; Megumu K. Saito. Induced pluripotent stem cells representing Nakajo-Nishimura syndrome. Inflammation and Regeneration 2019, 39, 11 .

AMA Style

Nobuo Kanazawa, Fumiko Honda-Ozaki, Megumu K. Saito. Induced pluripotent stem cells representing Nakajo-Nishimura syndrome. Inflammation and Regeneration. 2019; 39 (1):11.

Chicago/Turabian Style

Nobuo Kanazawa; Fumiko Honda-Ozaki; Megumu K. Saito. 2019. "Induced pluripotent stem cells representing Nakajo-Nishimura syndrome." Inflammation and Regeneration 39, no. 1: 11.

Letter to the editor
Published: 06 May 2019 in The Journal of Dermatology
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Kayo Kunimoto; Fumiko Honda‐Ozaki; Megumu K. Saito; Fukumi Furukawa; Nobuo Kanazawa. Beneficial effect of methotrexate on a child case of Nakajo–Nishimura syndrome. The Journal of Dermatology 2019, 46, e365 -e367.

AMA Style

Kayo Kunimoto, Fumiko Honda‐Ozaki, Megumu K. Saito, Fukumi Furukawa, Nobuo Kanazawa. Beneficial effect of methotrexate on a child case of Nakajo–Nishimura syndrome. The Journal of Dermatology. 2019; 46 (10):e365-e367.

Chicago/Turabian Style

Kayo Kunimoto; Fumiko Honda‐Ozaki; Megumu K. Saito; Fukumi Furukawa; Nobuo Kanazawa. 2019. "Beneficial effect of methotrexate on a child case of Nakajo–Nishimura syndrome." The Journal of Dermatology 46, no. 10: e365-e367.

Case report
Published: 31 January 2019 in International Journal of Hematology
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Aggressive natural killer cell leukemia (ANKL) is a rare neoplasm characterized by the systemic infiltration of Epstein–Barr virus (EBV)-associated NK cells, and rapidly progressive clinical course. We report the case of a 45-year-old man with intellectual disability who developed ANKL, and describe the identification of a novel genetic mutation of coiled-coil domain-containing 22 (CCDC22). He presented with persistent fever, severe pancytopenia, and hepatosplenomegary. Following bone marrow aspiration, numerous hemophagocytes were identified. High EBV viral load was detected in NK cells fractionation by qPCR. The initial diagnosis was EBV-related hemophagocytic lymphohistiocytosis (EBV–HLH). A combination of immunosuppressive drugs and chemotherapy was administered, but was unsuccessful in controlling the disease. Therefore, he was treated with HLA-matched related allogeneic hematopoietic stem cell transplantation. However, his condition deteriorated within 30 days, resulting in fatal outcome. Autopsy revealed many EBV-infected NK cells infiltrating major organs, consistent with ANKL. Furthermore, whole-exome sequencing identified a novel missense mutation of the CCDC22 gene (c.112G>A, p.V38M), responsible for X-linked intellectual disability (XLID). CCDC22 has been shown to play a role in NF-κB activation. Our case suggests that CCDC22 mutation might be implicated in pathogenesis of EBV–HLH and NK-cell neoplasms as well as XLID via possibly affecting NF-κB signaling.

ACS Style

Yusuke Yamashita; Akinori Nishikawa; Yoshifumi Iwahashi; Masakazu Fujimoto; Izumi Sasaki; Hiroyuki Mishima; Akira Kinoshita; Hiroaki Hemmi; Nobuo Kanazawa; Kouichi Ohshima; Ken-Ichi Imadome; Shin-Ichi Murata; Koh-Ichiro Yoshiura; Tsuneyasu Kaisho; Takashi Sonoki; Shinobu Tamura. Identification of a novel CCDC22 mutation in a patient with severe Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis and aggressive natural killer cell leukemia. International Journal of Hematology 2019, 109, 744 -750.

AMA Style

Yusuke Yamashita, Akinori Nishikawa, Yoshifumi Iwahashi, Masakazu Fujimoto, Izumi Sasaki, Hiroyuki Mishima, Akira Kinoshita, Hiroaki Hemmi, Nobuo Kanazawa, Kouichi Ohshima, Ken-Ichi Imadome, Shin-Ichi Murata, Koh-Ichiro Yoshiura, Tsuneyasu Kaisho, Takashi Sonoki, Shinobu Tamura. Identification of a novel CCDC22 mutation in a patient with severe Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis and aggressive natural killer cell leukemia. International Journal of Hematology. 2019; 109 (6):744-750.

Chicago/Turabian Style

Yusuke Yamashita; Akinori Nishikawa; Yoshifumi Iwahashi; Masakazu Fujimoto; Izumi Sasaki; Hiroyuki Mishima; Akira Kinoshita; Hiroaki Hemmi; Nobuo Kanazawa; Kouichi Ohshima; Ken-Ichi Imadome; Shin-Ichi Murata; Koh-Ichiro Yoshiura; Tsuneyasu Kaisho; Takashi Sonoki; Shinobu Tamura. 2019. "Identification of a novel CCDC22 mutation in a patient with severe Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis and aggressive natural killer cell leukemia." International Journal of Hematology 109, no. 6: 744-750.

Case report
Published: 25 October 2018 in Modern Rheumatology Case Reports
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Nakajo-Nishimura syndrome (NNS) is an inherited inflammatory and wasting disease caused by a distinct homozygous mutation of the PSMB8 gene, which encodes the β5i subunit of the immunoproteasome. Although NNS was originally reported in Japan more than 70 years ago, related diseases with an overlapping entity, namely joint contractures, muscular atrophy, microcytic anemia and panniculitis-associated lipodystrophy (JMP) syndrome and chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome, have recently been reported and these three diseases are now collectively referred to as proteasome-associated autoinflammatory syndromes (PRAAS). Although some distinct characteristics can be pointed out in each disease, most patients with these diseases commonly start to show inflammatory attacks in infancy and, after growing-up, clinically resemble progeria with marked emaciation especially in the upper body. Notably, some NNS cases with premature or sudden death have been reported and cardiac failure was considered to be a major cause of death. Here we report a Japanese male case with NNS, who had received no continuous medication and died of CO2 narcosis (respiratory acidosis) triggered by an acute septic infection in the absence of cardiac failure at 47 years of age. Due to a remarkable lipomuscular atrophy and contracture of the chest wall, CO2 narcosis should be noted as an important complication of NNS/PRAAS, which can develop into premature death.

ACS Style

Nobuo Kanazawa; Mariko Hara; Tomoyuki Hara; Kayo Kunimoto; Naoya Mikita; Fukumi Furukawa. CO2 narcosis as a notable cause of premature death in Nakajo-Nishimura syndrome. Modern Rheumatology Case Reports 2018, 3, 74 -78.

AMA Style

Nobuo Kanazawa, Mariko Hara, Tomoyuki Hara, Kayo Kunimoto, Naoya Mikita, Fukumi Furukawa. CO2 narcosis as a notable cause of premature death in Nakajo-Nishimura syndrome. Modern Rheumatology Case Reports. 2018; 3 (1):74-78.

Chicago/Turabian Style

Nobuo Kanazawa; Mariko Hara; Tomoyuki Hara; Kayo Kunimoto; Naoya Mikita; Fukumi Furukawa. 2018. "CO2 narcosis as a notable cause of premature death in Nakajo-Nishimura syndrome." Modern Rheumatology Case Reports 3, no. 1: 74-78.

Original article
Published: 08 October 2018 in The Journal of Dermatology
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The role of eosinophil in systemic sclerosis (SSc) is still controversial. In the present study, the relationship between skin ulcers and peripheral blood eosinophilia were analyzed in patients with SSc. We retrospectively investigated the clinical records of all patients who were diagnosed with SSc on the basis of American College of Rheumatology/European League Against Rheumatism 2013 criteria, and were followed up for more than 2 years at Wakayama Medical University. As a result, maximum eosinophil counts during the 2‐year follow‐up period were 20–983/mm3 (median, 270), whereas maximum eosinophil percentages were 0.5–14.1% (median, 5.3%) in peripheral blood of 47 SSc patients. On the other hand, patients with skin ulcers during the 2‐year follow up showed significantly increased maximum eosinophil counts compared with those without (median, 520 vs 228/mm3; P = 0.0001). Maximum eosinophil percentage was also significantly higher in patients with skin ulcers (median, 9.7% vs 4.6%; P = 0.00001). To note, in four of the nine patients with skin ulcers, the timing of emerging of the maximum eosinophil counts was associated with the ulcer development during the 2‐year follow up. These results suggest that eosinophils are involved in the pathogenesis of vascular dysfunction of SSc. Larger studies should be performed to clarify the exact mechanism of ulcer formation caused by eosinophilia in SSc patients in the future.

ACS Style

Tomoyuki Hara; Takaharu Ikeda; Yutaka Inaba; Kayo Kunimoto; Naoya Mikita; Chikako Kaminaka; Nobuo Kanazawa; Yuki Yamamoto; Kayoko Tabata; Takao Fujii; Masatoshi Jinnin. Peripheral blood eosinophilia is associated with the presence of skin ulcers in patients with systemic sclerosis. The Journal of Dermatology 2018, 46, 334 -337.

AMA Style

Tomoyuki Hara, Takaharu Ikeda, Yutaka Inaba, Kayo Kunimoto, Naoya Mikita, Chikako Kaminaka, Nobuo Kanazawa, Yuki Yamamoto, Kayoko Tabata, Takao Fujii, Masatoshi Jinnin. Peripheral blood eosinophilia is associated with the presence of skin ulcers in patients with systemic sclerosis. The Journal of Dermatology. 2018; 46 (4):334-337.

Chicago/Turabian Style

Tomoyuki Hara; Takaharu Ikeda; Yutaka Inaba; Kayo Kunimoto; Naoya Mikita; Chikako Kaminaka; Nobuo Kanazawa; Yuki Yamamoto; Kayoko Tabata; Takao Fujii; Masatoshi Jinnin. 2018. "Peripheral blood eosinophilia is associated with the presence of skin ulcers in patients with systemic sclerosis." The Journal of Dermatology 46, no. 4: 334-337.