Prof. Dr. Hai-Yang Liu

High-valent cobalt–oxo complexes are reactive transient intermediates in a number of oxidative transformation processes e.g., water oxidation and oxygen atom transfer reactions. Studies of cobalt–oxo complexes are very important for understanding the mechanism of the oxygen evolution center in natural photosynthesis, and helpful to replicate enzyme catalysis in artificial systems. This review summarizes the development of identification of high-valent cobalt–oxo species of tetrapyrrolic macrocycles and N-based ligands in oxidation of organic substrates, water oxidation reaction and in the preparation of cobalt–oxo complexes.

26 June 2017 in Dalton Transactions

Journal Article

Synthesis, characterization and in vitro and in vivo photodynamic activities of a gallium( iii ) tris(ethoxycarbonyl)corrole

Hua-Hua Wang

Corroles have been previously demonstrated to be a new and promising photosensitizer (PS) in photodynamic therapy (PDT) for cancer cells. This research reported the preparation of an electron-deficient flat gallium(III) tris(ethoxycarbonyl)corrole (1-Ga). Its in vitro PDT activities towards different cancer cell lines were examined, and the best PDT activity was observed in A549 cell lines. 1-Ga could penetrate the cell membrane rapidly and exhibit remarkable photo-cytotoxicity. 1-Ga can induce A549 cell apoptosis via ROS-mediated mitochondrial pathways, in which p38 and sirt-1 proteins play a key role. A PTD test in vivo showed that 1-Ga can significantly reduce the growth of A549 xenografted tumor cells without an obvious loss of mice weight upon PDT treatment.

About Me

Prof. Dr. Hai-Yang Liu currently works as a Professor at the School of Chemistry and Chemical Engineering, South China University of Technology. He obtained a B.Sc. at Jiangxi University, and an M.Sc. and a Ph.D. at Zhongshan University. His research areas are the synthesis of functional macrocyclic porphyrin and corrole complexes, catalytic oxidation of organic substrates by metal corrolate and porphyrin, bioinorganic chemistry of porphyrin and corrole, self-assembled supramolecular porphyrin and corrole array with useful properties, and photo-physical property and electronic structure of metalloporphyrin and metal correlates. His current research projects are 1. photodynamic antitumor activity of corrole complexes. 2. Metal corrole-catalyzed organic reactions. 3. Metal corrole-based electrocatalytic hydrogen evolution reaction and oxygen reduction reaction.

Prof. Dr. Hai-Yang Liu

Prof. Dr. Hai-Yang Liu

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