Fms-like tyrosine kinase-3 (FLT3) mutations occur in approximately 30% of acute myeloid leukemia (AML) cases, suggesting FLT3 as an attractive target for AML treatment. Early FLT3 inhibitors enhanc...

Sn58Bi solder is considered a promising lead-free solder that meets the performance requirements, with the advantages of good wettability and low cost. However, the low melting point characteristic of Sn58Bi poses a serious threat to the high-temperature reliability of electronic products. In this study, Sn58Bi solder alloy based on nickel (Ni) functionalization was successfully synthesized, and the effect of a small amount of Ni on creep properties and hardness of Cu/Sn58Bi/Cu micro solder joints at different temperatures (25 °C, 50 °C, 75 °C, 100 °C) was investigated using a nanoindentation method. The results indicate that the nanoindentation depth of micro solder joints exhibits a non-monotonic trend with increasing Ni content at different temperatures, and the slope of the indentation stage curve decreases at 100 °C, showing that the micro solder joints undergo high levels of softening. According to the observation of indentation morphology, Ni doping can reduce the indentation area and accumulation around the indentation, especially at 75 °C and 100 °C. In addition, due to the severe creep phenomenon at 100 °C, the indentation hardness rapidly decreases. The indentation hardness values of micro solder joints of Cu/Sn58Bi/Cu, Cu/Sn58Bi-0.1Ni/Cu, and Cu/Sn58Bi-0.2Ni/Cu at 100 °C are 14.67 ± 2.00 MPa, 21.05 ± 2.00 MPa, and 20.13 ± 2.10 MPa, respectively. Nevertheless, under the same temperature test conditions, the addition of Ni elements can improve the high-temperature creep resistance and hardness of Cu/Sn58Bi/Cu micro solder joints.

The quality of threaded connection is an important factor affecting the service life of equipment. Extruded thread has stronger mechanical properties than traditional cutting thread. The forming of magnesium alloy AZ91D internal thread by electromagnetic induction heating assisted extrusion is a new processing method. In this work, on the basis of this process, the height and performance of internal thread are selected as the evaluation index, and the response surface method is used to analyze the influence of the process parameters on the internal thread performance. The range of process parameters (auxiliary heating temperature, hole diameter, machine tool speed) is determined by slip line and empirical method, the test data are simulated, modeled and compared with the response surface analysis method, and the best mathematical model is selected to establish the regression model, the three-dimensional response surface curve of tooth height rate and maximum tensile force is obtained. Through simulation and prediction, it is found that the hole diameter and auxiliary heating temperature have significant influence on the tooth height rate and maximum tensile force of internal thread, and the order is that the hole diameter is larger than the auxiliary heating temperature than the machine tool speed. The research results show that the measured value of tooth height rate and maximum tensile force are close to the predicted value, and the errors are 1.8% and 2.7% respectively, and the model fits well. The better forming process parameters are as follows: auxiliary heating temperature to be 220 °C, hole diameter to be 11.35 mm, machine tool speed to be200 r/min. under this parameter, the tooth height rate and maximum tensile force to be 89.056% and 38.824 KN. At the same time, it is found that with the increase of thread height, the maximum tensile force of thread is also increasing, and the thread height affects the performance of thread. Finally, the optimal process parameters are obtained by response surface method, which improves the tensile properties of extruded internal threads.