Rita Casadio, after her degree in physics from the University of Bologna, Italy, attended several courses both in Italy and abroad and acquired experience and theoretical background in different fields, such as Computer Science, Membrane and Protein Biophysics, Bioenergetics, and Irreversible Thermodynamics. After working in laboratories of biophysics both in the United States and Germany in 1987, Rita Casadio became an Assistant Professor of Biophysics at the University of Bologna, Italy. Since 1 October 2003, she has been a full Professor of Biochemistry/Bioinformatics/Biophysics at UNIBO. Rita Casadio worked in membrane and protein biophysics (particularly with bacteriorhodopsin from Halobacterium Halobium and F1F0 ATPases from mesophilic organisms), both experimentally and theoretically. Presently, she is interested in the computer modelling of relevant biological processes, such as protein folding and modelling, protein–protein interaction, genome annotation, protein interaction networks, and SNPs search and annotation and their effect on protein stability. One major field of research is the development of specific software for problem solving the large-scale analysis of biomedical and biotechnological data out of genome sequencing or experiments on proteomes and interactomes. Methods are based on neural networks, hidden Markov models, support vector machines, conditional random fields, and their combinations.