Immunotherapy of cancer is emerging as a powerful weapon in the oncological armamentarium. Considerable efforts are being made to harness the cytotoxic potential of the T cells to eradicate cancer. However, the elimination of established tumors is impeded due to the dysfunctionality of anti-tumor T cells at the tumor sites. The major objective of our lab is to understand the mechanism(s) dampening the objective repose of anti-tumor T cells. Primarily we are focusing on: 1. Elucidating the role of cellular metabolisms in regulating the anti-tumor potential of T cells. 2. Determining the crosstalk between metabolic adaptation and stress response pathways in modulating the therapeutic efficacy of anti-tumor T cells. 3. Determining the role of metabolic requirements in shaping up the functionality of tumor-associated myeloid cells.