The objective of this work is to study the coupling of two efficient optimization techniques, Aerodynamic Shape Optimization (ASO) and Topology Optimization (TO), in 2D airfoils. To achieve such goal two open-source codes, SU2 and Calculix, are employed for ASO and TO, respectively, using the Sequential Least SQuares Programming (SLSQP) and the Bi-directional Evolutionary Structural Optimization (BESO) algorithms; the latter is well-known for allowing the addition of material in the TO which constitutes, as far as our knowledge, a novelty for this kind of application. These codes are linked by means of a script capable of reading the geometry and pressure distribution obtained from the ASO and defining the boundary conditions to be applied in the TO. The Free-Form Deformation technique is chosen for the definition of the design variables to be used in the ASO, while the densities of the inner elements are defined as design variables of the TO. As a test case, a widely used benchmark transonic airfoil, the RAE2822, is chosen here with an internal geometric constraint to simulate the wing-box of a transonic wing. First, the two optimization procedures are tested separately to gain insight and then are run in a sequential way for two test cases with available experimental data: (i) Mach 0.729 at $\alpha ={2.31}^{°}$; and (ii) Mach 0.730 at $\alpha ={2.79}^{°}$. In the ASO problem, the lift is fixed and the drag is minimized; while in the TO problem, compliance minimization is set as the objective for a prescribed volume fraction. Improvements in both aerodynamic and structural performance are found, as expected: the ASO reduced the total pressure on the airfoil surface in order to minimize drag, which resulted in lower stress values experienced by the structure.