To meticulously establish an efficient photothermal multifunctional hydrogel dressing is a prospective strategy for the treatment of diabetic chronic wounds. Herein, glucose oxidase (GOx) was added to polydopamine/acrylamide (PDA/AM) hydrogels to reduce hyperglycemia to a normal level (3.9–6.1 mmol L⁻¹) and enhance compressive properties (55 kPa) and adhesive properties (32.69 kPa), which are capable of hemostasis in the wound. Then, MnO₂ nanoparticles were encapsulated into a polydopamine/acrylamide (PDA/AM) hydrogel, endowing it with excellent antibacterial properties (E. coli and S. aureus were 97.87% and 99.99%) under the irradiation of 808 nm NIR; meanwhile, the biofilm was eliminated completely. Besides, O₂ was generated (18 mg mL⁻¹) by the decomposition of H₂O₂ under the catalysis of MnO₂, which could accelerate the formation of angiogenesis and promote the crawling and proliferation of cells. Furthermore, the diabetic wound in vivo treated with the PDA/AM/GOx/MnO₂ hydrogel had a less inflammatory response and faster healing speed, which was completely healed in 14 days. Therefore, the multifunctional hydrogels with the capability of high compressible, hemostasis, antibacterial, hyperglycemia manipulation, and O₂ generation, demonstrate promise in diabetic chronic wound dressing.

The hydrophilic copolyester polyethylene terephthalate (PET) (ENCDP-X) was successfully synthesized by chemical modification consisting of copolymerization and blending and the comonomers, including sodium isophthalate-5-sulfonate (SIPE), polyethylene glycol (PEG), 2,2-dimethyl-1,3-propanediol (NPG) and matting agent TiO₂ with different content. Moreover, the structural characterization of sequential structure, crystallization and thermal properties were studied. The results showed that the comonomers were successfully embedded in the copolyester, the actual molar ratio in the copolyester was consistent with the relative feed ratio and the degree of randomness was calculated to be 0.99, showing that the random copolymers synthesized during the melt polycondensation process and the chemical structure was roughly consistent with the expected molecular chain sequence structure. The thermal parameters of the modified copolyester, containing the glass transition temperature (T_g), melting point (T_m), crystallinity (X_c) and thermal degradation temperature, were decreased, and the cold crystallization temperature (T_c) was increased. In addition, with the increasing of the TiO₂ content, it improves the thermal performance of the copolyester and it is beneficial to processing and application. The above conclusion is further verified by non-isothermal kinetic analysis. In addition, the copolyester exhibited the better hydrophilicity than pure PET.