Our designed chemosensor, rhodamine-HBT-dyad (RHD), selectively detects two biologically important ions (Al ³⁺ and Zn ²⁺ ) at two different wavelengths (red and green, respectively) through FRET and ESIPT in vitro and in vivo .

A new fluorescence rhodamine derivative bearing an 8-aminoquinoline moiety has been designed and synthesized for selective sensing of Pd²⁺ in the presence of other competing metal ions in aqueous media. Pd²⁺ induced spirolactam ring opening of rhodamine is confirmed for the first time by the X-ray crystal structure of the bound Pd²⁺-complex.