Spatial characteristics of brain matter affect dynamics of informational flow. It seems important to investigate into the topology of neural information to better understand biological neural nets as well as for their computer science analogs. Mathematical braids are proposed as tool for modeling the neuronal topology. Neurological basis of neuronal path is reviewed. We demonstrate mathematical algorithms for path description and transformation. A simulation environment for neural braid construction and transformation is implemented. Experimental evaluation of 1310719 braid-defined neural topologies illustrates how neural path intersections affect information processing and memory recall. The mathematical representation of synaptic pruning is proposed. Pruning of neural nets shows the applicability of the approach to the simplification of neural graphs for computational resource saving.

Biological neurons have adaptive nature and perform complex computations involving the filtering of redundant information. However, most common neural cell models, including biologically plausible, such as Hodgkin-Huxley or Izhikevich, do not possess predictive dynamics on a single-cell level. Moreover, the modern rules of synaptic plasticity or interconnections weights adaptation also do not provide grounding for the ability of neurons to adapt to the ever-changing input signal intensity. While natural neuron synaptic growth is precisely controlled and restricted by protein supply and recycling, weight correction rules such as widely used STDP are efficiently unlimited in change rate and scale. The present article introduces new mechanics of interconnection between neuron firing rate homeostasis and weight change through STDP growth bounded by abstract protein reserve, controlled by the intracellular optimization algorithm. We show how these cellular dynamics help neurons filter out the intense noise signals to help neurons keep a stable firing rate. We also examine that such filtering does not affect the ability of neurons to recognize the correlated inputs in unsupervised mode. Such an approach might be used in the machine learning domain to improve the robustness of AI systems.

Here we present the model of bio-inspired neuron, and synaptic plasticity, incorporating cellular homeostasis. Network of such neurons is used for multi-goal oriented control task. It was showed that such a model provides adaptive and robust behavior for the controlled agent.