Chien-Ming Shih

Prof. Chien-Ming Shih

orcid

Research Focus & Metrics

Academic Career Length

40Years (1987-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 October 1992 in The Journal of Infectious Diseases
Verified
Journal Article
Closed access
PDF file
Chien-Ming ShihChien-Ming Shih
Chien-Ming Shih
RPRichard J. Pollack
Richard J. Pollack
STSam R. Telford
Sam R. Telford
ASAndrew Spielman
Andrew Spielman
To determine whether the agent of Lyme disease disseminates in vertebrate hosts directly after deposition by an infecting tick, a 6-mm disk of skin was excised from the sites where nymphal Ixodes dammini ticks infected by Lyme disease spirochetes, Borrelia burgdorferi, had fed. Infection in each mouse was tested by examining xenodiagnostic ticks that had engorged on these mice 4 weeks later and by serologic testing. Generalized infection was aborted when the site of inoculation was excised within 2 days after the infecting tick detached but not after 2 weeks. In contrast, all mice became infected when the bite site remained intact. Spirochetes could be cultured from the tissues around the site of attachment solely when the sample was ablated within a week after infecting ticks detached. These observations suggest that infecting ticks deliver the agent of Lyme disease directly into the skin and that such spirochetes multiply locally for some days before disseminating to remote sites.

1 February 2017 in Acta Tropica
Verified
Journal Article
Closed access
LCLi-Lian Chao
Li-Lian Chao
HLHsin-Ting Liao
Hsin-Ting Liao
THTsung-Yu Ho
Tsung-Yu Ho
Chien-Ming ShihChien-Ming Shih
Chien-Ming Shih

1 May 2002 in The American Journal of Tropical Medicine and Hygiene
Verified
Journal Article
Closed access
Chien-Ming ShihChien-Ming Shih
Chien-Ming Shih
LCLi-Lian Chao
Li-Lian Chao
CYChia-Peng Yu
Chia-Peng Yu
Read the full review for this F1000Prime recommended article: Chemotactic migration of the Lyme disease spirochete (Borrelia burgdorferi) to salivary gland extracts of vector ticks.

14 August 2009 in Biochemical and Biophysical Research Communications
Verified
Journal Article
Closed access
NDNiann-Tzyy Dai
Niann-Tzyy Dai
MYMing-Kung Yeh
Ming-Kung Yeh
CCChiao-Hsi Chiang
Chiao-Hsi Chiang
KCKe-Chi Chen
Ke-Chi Chen
TLTsung-Hsun Liu
Tsung-Hsun Liu
EAE.F. Adams
E.F. Adams

31 January 2009 in Experimental and Applied Acarology
Verified
Journal Article
Closed access
PDF file
LCLi-Lian Chao
Li-Lian Chao
WWWen-Jer Wu
Wen-Jer Wu
Chien-Ming ShihChien-Ming Shih
Chien-Ming Shih

16 November 2020 in Experimental and Applied Acarology
Verified
Journal Article
Closed access
PDF file
LCLi-Lian Chao
Li-Lian Chao
CCChantel Tamar Castillo
Chantel Tamar Castillo
Chien-Ming ShihChien-Ming Shih
Chien-Ming Shih