Drought is a natural creeping threat with numerous damaging effects in various aspects of human life. Accurate drought prediction is a promising step in helping policy makers to set drought risk management strategies. To fulfill this purpose, choosing appropriate models plays an important role in predicting approach. In this study, different models of Artificial Neural Network (ANN) are employed to predict short and long-term of droughts by using Standardized Precipitation Index (SPI) at different time scales, including 3, 6, 12, 24 and 48 months in Tabriz city, Iran. To this end, different combination of calculated SPI and time series of various hydro-meteorological variables, such as precipitation, wind velocity, relative humidity and sunshine hours for years 1992 to 2010 are used to train the ANN models. In order to compare the models performances, some well-known measures, namely RMSE, Mean Absolute Error (MAE) and Correlation Coefficient (CC) are utilized in the present study. The results illustrate that the application of all hydro-meteorological variables significantly improves the prediction of SPI at different time scales.