(1) Background: Balance decline is highly prevalent in people suffering from chronic ankle instability (CAI). The control of balance depends upon multiple neurophysiologic systems including the activation of cortical brain regions (e.g., the primary sensorimotor cortex). The excitability of this region, however, is diminished in people with CAI. In this pilot double-blinded randomized controlled trial, we tested the effects of high-definition transcranial direct current stimulation (HD-tDCS) designed to facilitate the excitability of M1 and S1 in combination with short-foot exercise (SFE) training on proprioception and dynamic balance performance in individuals with CAI. (2) Methods: Thirty young adults completed baseline assessments including the Active Movement Extent Discrimination Apparatus (AMEDA), Joint Position Reproduction (JPR) test, Y-balance test, and the Sensory Organization Test (SOT). They were then randomized to receive a four-week intervention of SFE in combination with tDCS (i.e., HD-tDCS+SFE) or sham (i.e., control) stimulation. Baseline assessments were repeated once-weekly throughout the intervention and during a two-week follow-up period. (3) Results: Twenty-eight participants completed this study. Blinding procedures were successful and no adverse events were reported. As compared to the control group, the HD-tDCS+SFE group exhibited significant improvements in the JPR test, the Y balance test, and the SOT at different time points. No group by time interaction was observed in AMEDA test performance. (4) Conclusions: HD-tDCS combined with SFE may improve dynamic balance and proprioception in CAI. Larger, more definitive trials with extended follow-up are warranted.

During the last two decades, esports, a highly competitive sporting activity, has gained increasing popularity. Both performance and competition in esports require players to have fine motor skills and physical and cognitive abilities in controlling and manipulating digital activities in a virtual environment. While strategies for building and improving skills and abilities are crucial for successful gaming performance, few effective training approaches exist in the fast-growing area of competitive esports. In this paper, we describe a non-invasive brain stimulation (NIBS) approach and highlight the relevance and potential areas for research while being cognizant of various technical, safety, and ethical issues related to NIBS when applied to esports.

This study investigated the effects of high-definition transcranial alternating current stimulation (HD-tACS) on cognitive–motor dual-task performance and upper-limb multi-joint motor control. Sixteen right-handed healthy male participants completed a double-blind, randomized crossover experiment involving active tACS and sham tACS conditions separated by a one-week washout interval. A 4 × 1 HD-tACS montage was applied over the left dorsolateral prefrontal cortex at 5 Hz for 20 min. Participants performed a synchronous cognitive–motor dual-task paradigm that combined an N-back working memory task with an upper-limb throwing task under different task difficulty levels. Task performance outcomes included accuracy, reaction time, release velocity, peak velocity, movement duration, and dual-task cost. Upper-limb motor control outcomes included elbow and wrist joint range of motion, peak angular velocity, and peak joint flexion and extension moments. Accuracy showed a significant Stimulation × Time interaction. Under active stimulation, adjusted accuracy increased by 5.4 percentage points in N1 and 10.1 percentage points in N2, whereas the corresponding changes under sham stimulation were not significant. Reaction time, release velocity, peak velocity, and movement duration showed no significant stimulation-related changes. Release-velocity DTC also showed a significant Stimulation × Time interaction across N1 and N2. Under active stimulation, the signed DTC shifted upward, indicating a smaller release-velocity decrement relative to N0. The task-specific follow-up was significant for N2 but not N1; however, the Stimulation × Time × Task interaction was not significant. Most upper-limb kinematic and kinetic outcomes showed no significant stimulation-related changes. Active HD-tACS was associated with higher accuracy and a favorable shift in release-velocity DTC, while most motor, kinematic, and kinetic outcomes were unchanged. The effects were limited to selected behavioral outcomes and did not differ significantly between N1 and N2.