In this study, the spatio-temporal variability of aerosol optical depth (AOD), total column ozone (TCO), and total column NO₂ (TCN) was identified over East Asia using long-term datasets from ground-based and satellite observations. Based on the statistical results, optimized spatio-temporal ranges for the validation study were determined with respect to the target materials. To determine both spatial and temporal ranges for the validation study, we confirmed that the observed datasets can be statistically considered as the same quantity within the ranges. Based on the thresholds of R²>0.95 (temporal) and R>0.95 (spatial), the basic ranges for spatial and temporal scales for AOD validation was within 30 km and 30 min, respectively. Furthermore, the spatial scales for AOD validation showed seasonal variation, which expanded the range to 40 km in summer and autumn. Because of the seasonal change of latitudinal gradient of the TCO, the seasonal variation of the north-south range is a considerable point. For the TCO validation, the north-south range is varied from 0.87° in spring to 1.05° in summer. The spatio-temporal range for TCN validation was 20 min (temporal) and 20–50 km (spatial). However, the nearest value of satellite data was used in the validation because the spatio-temporal variation of TCN is large in summer and autumn. Estimation of the spatio-temporal variability for respective pollutants may contribute to improving the validation of satellite products.