Industry 4.0 provides a tremendous potential of data from the work floor. For manufacturing companies, these data can be very useful in order to support assembly operators. In literature, a lot of contributions can be found that present models to describe both the learning and forgetting effect of manual assembly operations. In this study, different existing models were compared in order to predict the cycle time after a break. As these models are not created for a real time prediction purpose, some adaptations are presented in order to improve the robustness and efficiency of the models. Results show that the MLFCM (modified learn-forget curve model) and the PID (power integration diffusion) model have the greatest potential. Further research will be performed to test both models and implement contextual factors. In addition, since these models only consider one fixed repetitive task, they don’t target mixed-model assembly operations. The learning and forgetting effect that executing each assembly task has on the other task executions differs based on the job similarity between tasks. Further research opportunities to implement this job similarity are listed.