Jamel El-Benna, Ph.D., Research Director in the Center of Research on Inflammation (CRI), INSERM-U1149, CNRS-ERL8252, University of Paris-Cité, Xavier Bichat Hospital, Paris, France. My research program has focused on understanding the molecular and cellular mechanisms of innate immunity and inflammation, in particular the regulation of reactive oxygen species (ROS) production by the phagocyte NADPH oxidase in neutrophils. As p47phox is a critical cytosolic component in the organization of the NADPH oxidase, my work has identified the p47phox phosphorylated sites and demonstrated their functional importance in the activation and priming of ROS production by neutrophils. We have also identified the proline isomerase Pin1 as a key enzyme in ROS production by human neutrophils. My group also identified and studied the phosphorylation of the other NADPH oxidase components (p67phox and gp91phox/NOX2) in human neutrophils and NOX1 in colon epithelial cells.