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Dichlorodiphenyltrichloroethane (DDT) is a persistent organic pollutant and one of the most widespread endocrine disrupting chemicals. The impact of low-dose exposure to DDT on the morphogenesis of the adrenal gland is still poorly understood. The development and function of zona glomerulosa in rats has been found to be associated with changes in the expression of the transcription factor Oct4 (Octamer 4), which is the most important player in cell pluripotency. The aim of the study was to investigate the morphogenesis and function of rat adrenal zona glomerulosa in rats exposed to low doses of DDT during prenatal and postnatal development and to determine the possible role of Oct4 in DDT-mediated structural and functional changes. The DDT-exposed rats demonstrated slower development and lower functional activity of the zona glomerulosa during the pubertal period associated with higher expression of Oct4. Further, accelerated growth and restoration of hormone production was associated with, firstly, a decrease in Oct4 expressing cells and secondly, the loss of the inverse relationship between basal aldosterone levels and the number of Oct4 expressing cells. Thus, the transcriptional factor Oct4 exhibited an altered pattern of expression in the DDT-exposed rats during postnatal development. The results of the study uncover a novel putative mechanism by which low doses of DDT disrupt the development of adrenal zona glomerulosa.
Nataliya Yaglova; Sergey Obernikhin; Dibakhan Tsomartova; Svetlana Nazimova; Valentin Yaglov; Elina Tsomartova; Elizaveta Chereshneva; Marina Ivanova; Tatiana Lomanovskaya. Impaired Morphogenesis and Function of Rat Adrenal Zona Glomerulosa by Developmental Low-Dose Exposure to DDT Is Associated with Altered Oct4 Expression. International Journal of Molecular Sciences 2021, 22, 6324 .
AMA StyleNataliya Yaglova, Sergey Obernikhin, Dibakhan Tsomartova, Svetlana Nazimova, Valentin Yaglov, Elina Tsomartova, Elizaveta Chereshneva, Marina Ivanova, Tatiana Lomanovskaya. Impaired Morphogenesis and Function of Rat Adrenal Zona Glomerulosa by Developmental Low-Dose Exposure to DDT Is Associated with Altered Oct4 Expression. International Journal of Molecular Sciences. 2021; 22 (12):6324.
Chicago/Turabian StyleNataliya Yaglova; Sergey Obernikhin; Dibakhan Tsomartova; Svetlana Nazimova; Valentin Yaglov; Elina Tsomartova; Elizaveta Chereshneva; Marina Ivanova; Tatiana Lomanovskaya. 2021. "Impaired Morphogenesis and Function of Rat Adrenal Zona Glomerulosa by Developmental Low-Dose Exposure to DDT Is Associated with Altered Oct4 Expression." International Journal of Molecular Sciences 22, no. 12: 6324.
Dichlorodiphenyltrichloroethane (DDT) is the most widespread, persistent pollutant and endocrine disruptor on the planet. Although DDT has been found to block androgen receptors, the effects of its low-dose exposure in different periods of ontogeny on the male reproductive system remain unclear. We evaluate sex steroid hormone production in the pubertal period and after maturation in male Wistar rats exposed to low doses of o,p’-DDT, either during prenatal and postnatal development or postnatal development alone. Prenatally and postnatally exposed rats exhibit lower testosterone production and increased estradiol and estriol serum levels after maturation, associated with the delayed growth of gonads. Postnatally exposed rats demonstrate accelerated growth of gonads and higher testosterone production in the pubertal period. In contrast to the previous group, they do not present raised estradiol production. All of the exposed animals exhibit a reduced conversion of progesterone to 17OH-progesterone after sexual maturation, which indicates putative attenuation of sex steroid production. Thus, the study reveals age-dependent outcomes of low-dose exposure to DDT. Prenatal onset of exposure results in the later onset of androgen production and the enhanced conversion of androgens to estrogens after puberty, while postnatal exposure induces the earlier onset of androgen secretion.
Nataliya Yaglova; Dibakhan Tsomartova; Sergey Obernikhin; Valentin Yaglov; Svetlana Nazimova; Elina Tsomartova; Elizaveta Chereshneva; Marina Ivanova; Tatiana Lomanovskaya. Differential Disrupting Effects of Prolonged Low-Dose Exposure to Dichlorodiphenyltrichloroethane on Androgen and Estrogen Production in Males. International Journal of Molecular Sciences 2021, 22, 3155 .
AMA StyleNataliya Yaglova, Dibakhan Tsomartova, Sergey Obernikhin, Valentin Yaglov, Svetlana Nazimova, Elina Tsomartova, Elizaveta Chereshneva, Marina Ivanova, Tatiana Lomanovskaya. Differential Disrupting Effects of Prolonged Low-Dose Exposure to Dichlorodiphenyltrichloroethane on Androgen and Estrogen Production in Males. International Journal of Molecular Sciences. 2021; 22 (6):3155.
Chicago/Turabian StyleNataliya Yaglova; Dibakhan Tsomartova; Sergey Obernikhin; Valentin Yaglov; Svetlana Nazimova; Elina Tsomartova; Elizaveta Chereshneva; Marina Ivanova; Tatiana Lomanovskaya. 2021. "Differential Disrupting Effects of Prolonged Low-Dose Exposure to Dichlorodiphenyltrichloroethane on Androgen and Estrogen Production in Males." International Journal of Molecular Sciences 22, no. 6: 3155.
Skin represents a natural barrier and a site of contact with antigens. Skin demonstrates higher intensity of immune reactions compared to other organs, which implies the additional cell interactions. Dendritic cells are traditionally considered as the main antigenpresenting cells of the skin, however, in recent years, some data on the ability of another population, mast cells, to perform antigenpresenting functions have appeared. The review presents novel data on the interaction of skin dendritic and mast cells, including formation of immune synapses, exchange of surface molecules, and transfer of secretory material. The authors have developed and presented a new concept for the initiation and modulation of immune responses provided by the functional dendritic cell–mast cell complex. Keywords: dendritic cells, mast cells, skin, immunological synapse, degranulatory synapse, immune response
N.V. Yaglova; S.S. Obernikhin; V.V. Yaglov; S.V. Nazimova. Role of skin dendritic and mast cells communications in triggering immune reactions. CLINICAL AND EXPERIMENTAL MORPHOLOGY 2021, 10, 1 .
AMA StyleN.V. Yaglova, S.S. Obernikhin, V.V. Yaglov, S.V. Nazimova. Role of skin dendritic and mast cells communications in triggering immune reactions. CLINICAL AND EXPERIMENTAL MORPHOLOGY. 2021; 10 (1):1.
Chicago/Turabian StyleN.V. Yaglova; S.S. Obernikhin; V.V. Yaglov; S.V. Nazimova. 2021. "Role of skin dendritic and mast cells communications in triggering immune reactions." CLINICAL AND EXPERIMENTAL MORPHOLOGY 10, no. 1: 1.
Objective ― impact of different time regimens of deuterium depletion on progression of syngeneic grafted tumor in mice was investigated. Material and Methods ― Experiment was performed on 64 C57Bl/6 mice divided into two groups with substitution of regular water for deuterium depleted water: 30 days prior to tumor cell inoculation and sinse the 1st day of inoculation. Mice taking destilled mineralized water were considered as a control group. Half of the mice were injected melanoma B16 cells subcutaneously for assessment of survival rate and tumor growth inhibition index. The other mice were intravenously injected melanoma cells for estimation of lung hematogenous metastasis. Results ― Deuterium depletion began at the day of tumor inoculation did not change the parameters of survival rate (38.83±7.69 days vs. 41.33±6.22days in the control). Tumor growth inhibition was found only at initial stage of tumor progression. Number of melanoma lung metastasis did not differ from the control values (32.30±6.12 and 28.33±5.38. consequently). The group of mice with preliminary consumption of deuterium depleted water demonstrated significantly higher survival rate (70.10±16.20 days), tumor inhibition index, and attenuation of lung metastasis (6.0±1.20). Conclusion ― Our findings demonstrate that deuterium depletion exerts antitumor effect by both inhibition of tumor growth and metastasis, but development of the effect is time-dependent.
Natalia V. Yaglova; Sergey S. Obernikhin; Valentin V. Yaglov; Svetlana V. Nazimova. Time-dependent effect of deuterium depletion on tumor growth and metastasis. Russian Open Medical Journal 2020, 9, 1 .
AMA StyleNatalia V. Yaglova, Sergey S. Obernikhin, Valentin V. Yaglov, Svetlana V. Nazimova. Time-dependent effect of deuterium depletion on tumor growth and metastasis. Russian Open Medical Journal. 2020; 9 (2):1.
Chicago/Turabian StyleNatalia V. Yaglova; Sergey S. Obernikhin; Valentin V. Yaglov; Svetlana V. Nazimova. 2020. "Time-dependent effect of deuterium depletion on tumor growth and metastasis." Russian Open Medical Journal 9, no. 2: 1.
The aim of the research was to study formation of thymic lymphocytes proliferative response to T cell mitogen Concanavalin A in 7, 42, and 70 days-old male Wistar rats developmentally exposed to low doses of endocrine disruptor dichlorodiphenyltrichloroethane (2.90 ± 0.13 μg/kg body weight). The thymus of the exposed rats did not show morphological abnormalities. Exposure to the endocrine disrupter was found to alter age-dependent changes of thymic lymphocyte proliferative activity and attenuate proliferative response to Concanavalin A in puberty and adulthood. Insufficient response to mitogen was mediated by higher content of actively proliferating Ki-67-positive lymphoblasts compared to the control values. Insufficient proliferative response to mitogen in developmentally exposed to the endocrine disruptor rats may provide higher risk of impaired cellular immune reactions.
Nataliya V. Yaglova; Elina S. Tsomartova; Sergey S. Obernikhin; Marina Y. Ivanova; Elizaveta V. Chereshneva; Svetlana G. Muhamedova; Tatiana A. Lomanovskaya; Valentin V. Yaglov. Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats. Heliyon 2020, 6, e03608 .
AMA StyleNataliya V. Yaglova, Elina S. Tsomartova, Sergey S. Obernikhin, Marina Y. Ivanova, Elizaveta V. Chereshneva, Svetlana G. Muhamedova, Tatiana A. Lomanovskaya, Valentin V. Yaglov. Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats. Heliyon. 2020; 6 (3):e03608.
Chicago/Turabian StyleNataliya V. Yaglova; Elina S. Tsomartova; Sergey S. Obernikhin; Marina Y. Ivanova; Elizaveta V. Chereshneva; Svetlana G. Muhamedova; Tatiana A. Lomanovskaya; Valentin V. Yaglov. 2020. "Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats." Heliyon 6, no. 3: e03608.
N.V. Yaglova; S.S. Obernikhin; V.V. Yaglov; E.P. Timokhina; S.V. Nazimova; D.A. Tsomartova. Age-dependent changes of mitochondrial structure regulate steroidogenic activity of rat adrenal cortical cells. CLINICAL AND EXPERIMENTAL MORPHOLOGY 2020, 9, 1 .
AMA StyleN.V. Yaglova, S.S. Obernikhin, V.V. Yaglov, E.P. Timokhina, S.V. Nazimova, D.A. Tsomartova. Age-dependent changes of mitochondrial structure regulate steroidogenic activity of rat adrenal cortical cells. CLINICAL AND EXPERIMENTAL MORPHOLOGY. 2020; 9 (1):1.
Chicago/Turabian StyleN.V. Yaglova; S.S. Obernikhin; V.V. Yaglov; E.P. Timokhina; S.V. Nazimova; D.A. Tsomartova. 2020. "Age-dependent changes of mitochondrial structure regulate steroidogenic activity of rat adrenal cortical cells." CLINICAL AND EXPERIMENTAL MORPHOLOGY 9, no. 1: 1.
We analyzed the expression of transcriptional factor Oct4 in rat adrenal cortical cells during postnatal development. It was found that Oct4 is expressed by typical cortical cells of the zona glomerulosa, zona fasciculata, and zona reticularis in pubertal and postpubertal periods. The maximum number of Oct4+ cells was found in the zona glomerulosa. An inverse correlation between the number of Oct4+ glomerulosa cells and serum level of aldosterone both in pubertal and postpubertal periods was revealed. After puberty, the number of Oct4+ glomerulosa cells directly correlated with the number of Ki-67+ cells. A hypothesis was put forward that Oct4 is involved in postnatal morphogenesis, regeneration, and functioning of the adrenal cortex.
Natalia Yaglova; Sergey Obernikhin; Svetlana Nazimova; Valentin Yaglov. Role of Transcription Factor Oct4 in Postnatal Development and Function of the Adrenal Cortex. Bulletin of Experimental Biology and Medicine 2019, 167, 568 -573.
AMA StyleNatalia Yaglova, Sergey Obernikhin, Svetlana Nazimova, Valentin Yaglov. Role of Transcription Factor Oct4 in Postnatal Development and Function of the Adrenal Cortex. Bulletin of Experimental Biology and Medicine. 2019; 167 (4):568-573.
Chicago/Turabian StyleNatalia Yaglova; Sergey Obernikhin; Svetlana Nazimova; Valentin Yaglov. 2019. "Role of Transcription Factor Oct4 in Postnatal Development and Function of the Adrenal Cortex." Bulletin of Experimental Biology and Medicine 167, no. 4: 568-573.
The effects of endocrine disrupters of transcriptional control of morphogenesis are poorly studied. Changes in the expression of transcriptional factor PRH and proliferation of adrenal cortical cells were analyzed in pubertal and postpubertal rats exposed prenatally and postnatally to low doses of endocrine disrupter DDT. In rats exposed to DDT, the expression of PRH and proliferation of adrenal cortical cells differed from those in control rats. Association between these parameters was weakened in the zona glomerulosa and zona reticularis and was absent in the zona fasciculata. These findings suggest that exposure to DDT in pre- and postnatal periods impairs the regulation of proliferative processes by transcriptional factor PRH in all zones of rat adrenal cortex, which can be a mechanism of the disruptive action of DDT.
N. V. Yaglova; D. A. Tsomartova; S. S. Obernikhin; S. V. Nazimova; V. V. Yaglov. Regulation of Proliferative Processes in Rat Adrenal Cortex by Transcriptional Factor PRH under Conditions of Developmental Exposure to Endocrine Disruptor DDT. Bulletin of Experimental Biology and Medicine 2019, 167, 404 -407.
AMA StyleN. V. Yaglova, D. A. Tsomartova, S. S. Obernikhin, S. V. Nazimova, V. V. Yaglov. Regulation of Proliferative Processes in Rat Adrenal Cortex by Transcriptional Factor PRH under Conditions of Developmental Exposure to Endocrine Disruptor DDT. Bulletin of Experimental Biology and Medicine. 2019; 167 (3):404-407.
Chicago/Turabian StyleN. V. Yaglova; D. A. Tsomartova; S. S. Obernikhin; S. V. Nazimova; V. V. Yaglov. 2019. "Regulation of Proliferative Processes in Rat Adrenal Cortex by Transcriptional Factor PRH under Conditions of Developmental Exposure to Endocrine Disruptor DDT." Bulletin of Experimental Biology and Medicine 167, no. 3: 404-407.
The structure of the thymus in newborn rats exposed in utero to endocrine disruptor DDT was studied. We found that exposure to low doses of DDT during pregnancy does not disturb thymus formation in the offspring, but leads to changes in its structure than manifested as slower lobulation, wider epithelium-free areas in the cortex, and lower number of thymic corpuscles in the medulla. The results attest to sensitivity of the reticuloepithelial stroma of the thymus to the effects of endocrine disruptor.
N. V. Yaglova; E. S. Tsomartova; S. V. Nazimova; S. S. Obernikhin; S. G. Mukhamedova; N. R. Pashina; D. O. Musaeva. Morphological Changes in the Thymus of Newborn Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during the Prenatal Period. Bulletin of Experimental Biology and Medicine 2019, 167, 297 -299.
AMA StyleN. V. Yaglova, E. S. Tsomartova, S. V. Nazimova, S. S. Obernikhin, S. G. Mukhamedova, N. R. Pashina, D. O. Musaeva. Morphological Changes in the Thymus of Newborn Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during the Prenatal Period. Bulletin of Experimental Biology and Medicine. 2019; 167 (2):297-299.
Chicago/Turabian StyleN. V. Yaglova; E. S. Tsomartova; S. V. Nazimova; S. S. Obernikhin; S. G. Mukhamedova; N. R. Pashina; D. O. Musaeva. 2019. "Morphological Changes in the Thymus of Newborn Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during the Prenatal Period." Bulletin of Experimental Biology and Medicine 167, no. 2: 297-299.
This study is focused on the role of the canonical Wnt-signaling pathway in morphogenesis and regeneration of the adrenal cortex in rats exposed to the endocrine disruptor dichlorodiphenyltrichloroethane (DDT) during prenatal and postnatal development. Hypoplasia of the zona glomerulosa and, to a greater extent, of the zona reticularis was associated with suppression of canonical Wnt. This data indicates the role of the Wnt-signaling pathway in the development of the zona reticularis. Circulatory disorders in the adrenal cortex led to focal necrosis of the zona fasciculata and subsequent activation of cell proliferation and regeneration, mediated by the inhibition of the canonical Wnt in it. Thus, the disturbance of activation of the canonical Wnt-signaling pathway can be considered as a mechanism of the disrupting effect of DDT in postnatal development.
N. V. Yaglova; D. A. Tsomartova; Sergey Obernikhin; S. V. Nazimova. The Role of the Canonical Wnt-Signaling Pathway in Morphogenesis and Regeneration of the Adrenal Cortex in Rats Exposed to the Endocrine Disruptor Dichlorodiphenyltrichloroethane during Prenatal and Postnatal Development. Biology Bulletin 2019, 46, 74 -81.
AMA StyleN. V. Yaglova, D. A. Tsomartova, Sergey Obernikhin, S. V. Nazimova. The Role of the Canonical Wnt-Signaling Pathway in Morphogenesis and Regeneration of the Adrenal Cortex in Rats Exposed to the Endocrine Disruptor Dichlorodiphenyltrichloroethane during Prenatal and Postnatal Development. Biology Bulletin. 2019; 46 (1):74-81.
Chicago/Turabian StyleN. V. Yaglova; D. A. Tsomartova; Sergey Obernikhin; S. V. Nazimova. 2019. "The Role of the Canonical Wnt-Signaling Pathway in Morphogenesis and Regeneration of the Adrenal Cortex in Rats Exposed to the Endocrine Disruptor Dichlorodiphenyltrichloroethane during Prenatal and Postnatal Development." Biology Bulletin 46, no. 1: 74-81.
электронный журнал: Клиническая и экспериментальная морфология
S.S. Obernikhin; N.V. Yaglova; S.V. Nazimova; V.V. Yaglov; E.P. Timokhina. Transcriptional regulation of morphogenesis of rat adrenal zona glomerulosa during postnatal development. CLINICAL AND EXPERIMENTAL MORPHOLOGY 2019, 8, 1 .
AMA StyleS.S. Obernikhin, N.V. Yaglova, S.V. Nazimova, V.V. Yaglov, E.P. Timokhina. Transcriptional regulation of morphogenesis of rat adrenal zona glomerulosa during postnatal development. CLINICAL AND EXPERIMENTAL MORPHOLOGY. 2019; 8 (2):1.
Chicago/Turabian StyleS.S. Obernikhin; N.V. Yaglova; S.V. Nazimova; V.V. Yaglov; E.P. Timokhina. 2019. "Transcriptional regulation of morphogenesis of rat adrenal zona glomerulosa during postnatal development." CLINICAL AND EXPERIMENTAL MORPHOLOGY 8, no. 2: 1.
N.V. Yaglova; Sergey Obernikhin; Dibakhan Tsomartova; M.J. Ivanova; N.L. Kartashkina; Yelizaveta Chereshneva. Skin Organogenesis and Dysmorphogenetic Factors in Skin Diseases (Review). Sovremennye tehnologii v medicine 2018, 10, 195 .
AMA StyleN.V. Yaglova, Sergey Obernikhin, Dibakhan Tsomartova, M.J. Ivanova, N.L. Kartashkina, Yelizaveta Chereshneva. Skin Organogenesis and Dysmorphogenetic Factors in Skin Diseases (Review). Sovremennye tehnologii v medicine. 2018; 10 (4):195.
Chicago/Turabian StyleN.V. Yaglova; Sergey Obernikhin; Dibakhan Tsomartova; M.J. Ivanova; N.L. Kartashkina; Yelizaveta Chereshneva. 2018. "Skin Organogenesis and Dysmorphogenetic Factors in Skin Diseases (Review)." Sovremennye tehnologii v medicine 10, no. 4: 195.
We studied secretory activity of adrenal zona fasciculata cells in pubertal rats exposed to low doses of endocrine disrupter DDT during prenatal and postnatal periods and only during postnatal period. In exposed animals, circulatory disturbances leading to degeneration and necrosis of cells as well as regeneration foci were revealed in the outer zona fasciculata. In rats exposed to DDT during the prenatal and postnatal periods, compensatory increase in secretory activity of cells due to increase in mitochondria content was noted in the inner zona fasciculata, which determined elevated serum concentration of corticosterone. In rats exposed to DDT only during the postnatal development, functional activity of zona fasciculata cells was suppressed, which attested to delayed upregulation of secretion.
N. V. Yaglova; Dibakhan Tsomartova; Sergey Obernikhin; Svetlana Nazimova; Valentin Yaglov. Changes in Secretory Activity of Adrenal Zona Fasciculata Cells in Pubertal Rats Exposed to Low Doses of DDT in Different Periods of Ontogeny. Bulletin of Experimental Biology and Medicine 2018, 166, 283 -286.
AMA StyleN. V. Yaglova, Dibakhan Tsomartova, Sergey Obernikhin, Svetlana Nazimova, Valentin Yaglov. Changes in Secretory Activity of Adrenal Zona Fasciculata Cells in Pubertal Rats Exposed to Low Doses of DDT in Different Periods of Ontogeny. Bulletin of Experimental Biology and Medicine. 2018; 166 (2):283-286.
Chicago/Turabian StyleN. V. Yaglova; Dibakhan Tsomartova; Sergey Obernikhin; Svetlana Nazimova; Valentin Yaglov. 2018. "Changes in Secretory Activity of Adrenal Zona Fasciculata Cells in Pubertal Rats Exposed to Low Doses of DDT in Different Periods of Ontogeny." Bulletin of Experimental Biology and Medicine 166, no. 2: 283-286.
Transcription factor PRH/Hhex suppresses cell proliferation and contributes to regulation of prenatal and postnatal ontogeny. Neurons of the peripheral nervous system and chromaffin cells were previously considered as non-expressing PRH/Hhex in postnatal development. In our study, the expression of PRH/Hhex in chromaffin cells of rat adrenal glands and association between the decrease of proliferation and activation of PRH/Hhex expression were demonstrated.
Natalia Yaglova; Sergey Obernikhin; Dibakhan Tsomartova; Svetlana Nazimova; Valentin Yaglov. Expression of Transcription Factor PRH/Hhex in Adrenal Chromaffin Cells in the Postnatal Development and Its Role in the Regulation of Proliferative Processes. Bulletin of Experimental Biology and Medicine 2018, 165, 508 -511.
AMA StyleNatalia Yaglova, Sergey Obernikhin, Dibakhan Tsomartova, Svetlana Nazimova, Valentin Yaglov. Expression of Transcription Factor PRH/Hhex in Adrenal Chromaffin Cells in the Postnatal Development and Its Role in the Regulation of Proliferative Processes. Bulletin of Experimental Biology and Medicine. 2018; 165 (4):508-511.
Chicago/Turabian StyleNatalia Yaglova; Sergey Obernikhin; Dibakhan Tsomartova; Svetlana Nazimova; Valentin Yaglov. 2018. "Expression of Transcription Factor PRH/Hhex in Adrenal Chromaffin Cells in the Postnatal Development and Its Role in the Regulation of Proliferative Processes." Bulletin of Experimental Biology and Medicine 165, no. 4: 508-511.
Dibakhan A. Tsomartova; Natalia V. Yaglova; Sergey S. Obernikhin; Svetlana V. Nazimova; Valentin V. Yaglov. Secretion of adrenal zona glomerulosa cells in rats exposed to low doses of dichlorodiphenyltrichloroethane during prenatal and postnatal development. Russian Open Medical Journal 2018, 7, e0302 .
AMA StyleDibakhan A. Tsomartova, Natalia V. Yaglova, Sergey S. Obernikhin, Svetlana V. Nazimova, Valentin V. Yaglov. Secretion of adrenal zona glomerulosa cells in rats exposed to low doses of dichlorodiphenyltrichloroethane during prenatal and postnatal development. Russian Open Medical Journal. 2018; 7 (3):e0302.
Chicago/Turabian StyleDibakhan A. Tsomartova; Natalia V. Yaglova; Sergey S. Obernikhin; Svetlana V. Nazimova; Valentin V. Yaglov. 2018. "Secretion of adrenal zona glomerulosa cells in rats exposed to low doses of dichlorodiphenyltrichloroethane during prenatal and postnatal development." Russian Open Medical Journal 7, no. 3: e0302.
Sergey Obernikhin; Natalia Yaglova; Dibakhan Tsomartova; V Torbek; M Ivanova. [EPIGENETIC REGULATION OF ADRENAL CHROMAFFIN CELLS DEVELOPMENT (REVIEW)]. Georgian medical news 2018, 138 -146.
AMA StyleSergey Obernikhin, Natalia Yaglova, Dibakhan Tsomartova, V Torbek, M Ivanova. [EPIGENETIC REGULATION OF ADRENAL CHROMAFFIN CELLS DEVELOPMENT (REVIEW)]. Georgian medical news. 2018; (278):138-146.
Chicago/Turabian StyleSergey Obernikhin; Natalia Yaglova; Dibakhan Tsomartova; V Torbek; M Ivanova. 2018. "[EPIGENETIC REGULATION OF ADRENAL CHROMAFFIN CELLS DEVELOPMENT (REVIEW)]." Georgian medical news , no. 278: 138-146.
Prenatal and postnatal exposure to low doses of the endocrine disruptor dichlorodiphenyltrichloroethane (DDT) leads to delayed activation of the canonical β-catenin/Wnt signaling in zona glomerulosa and zona reticularis of the adrenal cortex in rats, which changed the rate of their postnatal development. Suppression of the Wnt pathway in zona fasciculata promotes its regeneration after DDT-induced blood circulation disorders and cell death.
Dibakhan Tsomartova; Natalia Yaglova; Valentin Yaglov. Changes in Canonical β-Catenin/Wnt Signaling Activation in the Adrenal Cortex of Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Prenatal and Postnatal Ontogeny. Bulletin of Experimental Biology and Medicine 2018, 164, 493 -496.
AMA StyleDibakhan Tsomartova, Natalia Yaglova, Valentin Yaglov. Changes in Canonical β-Catenin/Wnt Signaling Activation in the Adrenal Cortex of Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Prenatal and Postnatal Ontogeny. Bulletin of Experimental Biology and Medicine. 2018; 164 (4):493-496.
Chicago/Turabian StyleDibakhan Tsomartova; Natalia Yaglova; Valentin Yaglov. 2018. "Changes in Canonical β-Catenin/Wnt Signaling Activation in the Adrenal Cortex of Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Prenatal and Postnatal Ontogeny." Bulletin of Experimental Biology and Medicine 164, no. 4: 493-496.
Sex differences in the expression of iodide transporter SLC5A5 and thyroid peroxidase in thyroid follicular epithelium and thyroid serum profile were assessed in pubertal rats exposed to endocrine disruptor DDT starting from the first postnatal day. It was found that exposure to DDT reduced expression of SLC5A5 in peripheral regions of thyroid lobes in males and in central regions in females. The most pronounced sex differences were observed in thyroid peroxidase expression that remained sensitive to thyroid stimulating hormone regulation in males and lost sensitivity to pituitary stimulation in females after exposure to disruptor, which determines more pronounced hypothyroidism in females.
Natalia Yaglova; Yu. P. Sledneva; Svetlana Nazimova; Sergey Obernikhin; Valentin Yaglov. Sex Differences in the Production of SLC5A5, Thyroid Peroxidase, and Thyroid Hormones in Pubertal Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Postnatal Ontogeny. Bulletin of Experimental Biology and Medicine 2018, 164, 430 -433.
AMA StyleNatalia Yaglova, Yu. P. Sledneva, Svetlana Nazimova, Sergey Obernikhin, Valentin Yaglov. Sex Differences in the Production of SLC5A5, Thyroid Peroxidase, and Thyroid Hormones in Pubertal Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Postnatal Ontogeny. Bulletin of Experimental Biology and Medicine. 2018; 164 (4):430-433.
Chicago/Turabian StyleNatalia Yaglova; Yu. P. Sledneva; Svetlana Nazimova; Sergey Obernikhin; Valentin Yaglov. 2018. "Sex Differences in the Production of SLC5A5, Thyroid Peroxidase, and Thyroid Hormones in Pubertal Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Postnatal Ontogeny." Bulletin of Experimental Biology and Medicine 164, no. 4: 430-433.
N.V. Yaglova; D.A. Tsomartova; V.V. Yaglov; S.S. Obernikhin; S.V. Nazimova. ALTERED SECRETION OF ADRENOMEDULLARY A-CELLS IN RATS AFTER DEVELOPMENTAL EXPOSURE TO LOW-DOSE DICHLORODIPHENYLTRICHLOROETHANE. CLINICAL AND EXPERIMENTAL MORPHOLOGY 2018, 27, 1 .
AMA StyleN.V. Yaglova, D.A. Tsomartova, V.V. Yaglov, S.S. Obernikhin, S.V. Nazimova. ALTERED SECRETION OF ADRENOMEDULLARY A-CELLS IN RATS AFTER DEVELOPMENTAL EXPOSURE TO LOW-DOSE DICHLORODIPHENYLTRICHLOROETHANE. CLINICAL AND EXPERIMENTAL MORPHOLOGY. 2018; 27 (3):1.
Chicago/Turabian StyleN.V. Yaglova; D.A. Tsomartova; V.V. Yaglov; S.S. Obernikhin; S.V. Nazimova. 2018. "ALTERED SECRETION OF ADRENOMEDULLARY A-CELLS IN RATS AFTER DEVELOPMENTAL EXPOSURE TO LOW-DOSE DICHLORODIPHENYLTRICHLOROETHANE." CLINICAL AND EXPERIMENTAL MORPHOLOGY 27, no. 3: 1.
D.A. Tsomartova; N.V. Yaglova; S.S. Obernikhin; S.V. Nazimova; Y.P. Sledneva; V.V. Yaglov. CHANGES IN ADRENAL ZONA GLOMERULOSA CELLS OF RATS EXPOSED TO LOW DOSES OF DDT DURING POSTNATAL DEVELOPMENT. CLINICAL AND EXPERIMENTAL MORPHOLOGY 2018, 26, 1 .
AMA StyleD.A. Tsomartova, N.V. Yaglova, S.S. Obernikhin, S.V. Nazimova, Y.P. Sledneva, V.V. Yaglov. CHANGES IN ADRENAL ZONA GLOMERULOSA CELLS OF RATS EXPOSED TO LOW DOSES OF DDT DURING POSTNATAL DEVELOPMENT. CLINICAL AND EXPERIMENTAL MORPHOLOGY. 2018; 26 (2):1.
Chicago/Turabian StyleD.A. Tsomartova; N.V. Yaglova; S.S. Obernikhin; S.V. Nazimova; Y.P. Sledneva; V.V. Yaglov. 2018. "CHANGES IN ADRENAL ZONA GLOMERULOSA CELLS OF RATS EXPOSED TO LOW DOSES OF DDT DURING POSTNATAL DEVELOPMENT." CLINICAL AND EXPERIMENTAL MORPHOLOGY 26, no. 2: 1.