COVID – 19 is a contagious disease caused by severe acute respiratory syndrome (SARS-CoV2). The rate at which COVID – 19-virus spread from epidemic to pandemic within a short period is quite alarming. As of July 2020, the Dashboard of the World Health Organization (WHO) recorded over 15 million COVID – 19 cases across 213 countries, with mortality of over 620,000. The governments and healthcare agencies responsible for mitigating the virus's spread have adopted several strategies to end the pandemic. However, all hands were on deck to establish the standard treatment modalities of SARS-CoV-2 through inventing new drugs, vaccine candidates, or repurposing the existing medicines and robust diagnostic tools, in addition to other technological innovations. Therefore, nanotechnology’s employment would play a vital role in bringing multidisciplinary ways of developing affordable, reliable, and powerful tools for diagnosis, in addition to personal protection and effective medicines. Additionally, nanosensors' application would significantly aid the diagnoses of the COVID–19 even on asymptomatic patients, and thus would be an essential means for determining its prevalence. Likewise, nanoscale fibers can optimize personal equipment protection and allow their reusability for medical and economic benefits. Accordingly, the literature was intensively reviewed by searching for the combinations of the research keywords in the official scientific databases such as Science Direct, PubMed, and Google Scholar. Hence, this research highlighted the perspective contributions of nanotechnology in the war against the COVID-19 pandemic.

There is an urgent need to address the global mortality of the COVID-19 pandemic, as it reached 6.3 million as of July 2022. As such, the experts recommended the mass diagnosis of SARS-CoV-2 infection at an early stage using nanotechnology-based sensitive diagnostic approaches. The development of nanobiosensors for Point-of-Care (POC) sampling of COVID-19 could ensure mass detection without the need for sophisticated laboratories or expert personnel. The use of Artificial Intelligence (AI) techniques for POC detection was also proposed. In addition, the utilization of various antiviral nanomaterials such as Silver Nanoparticles (AgNPs) for the development of masks for personal protection mitigates viral transmission. Nowadays, nano-assisted vaccines have been approved for emergency use, but their safety and effectiveness in the mutant strain of the SARS-CoV-2 virus remain challenging. Methodology: Updated literature was sourced from various research indexing databases such as PubMed, SCOPUS, Science Direct, Research Gate and Google Scholars. Result: We presented the concept of novel nanotechnology researched discovery, including nano-devices, electrochemical biosensing, nano-assisted vaccine, and nanomedicines, for use in recent times, which could be a formidable step for future management of COVID-19.

The outbreak of pandemic COVID-19 mounts overall pressure on healthcare and modern societies. The intervention of nanotechnology will play a vital role in bringing multi-disciplinary ways of developing affordable, reliable, and powerful tools for diagnosis, personal protection, and new effective medicines. Moreover, employing nanosensors will significantly aid to diagnose the viruses even on asymptomatic patients. Likewise, the use of nanoscale fibers can optimize the protection affinity of personal protective equipment and facemasks and allows their reusability for medical and economical benefit. This research was designed purposely to highlight the perspective contributions of nanotechnology in the war against COVID-19 pandemic

The World Health Organization (WHO) declared COVID -19 a pandemic on March 11, since then, scientists have been working tirelessly to develop drugs and vaccines against it. Unfortunately, yet there is no approved drug or vaccine available for the treatment of the virus. More so, developing effective antiviral and vaccine against COVID 19 remains a major challenge. However, numerous NPs is known to have possessed an inherit antiviral effect and they have been utilized as a promising carrier for effective targeted delivery with low side effect/adverse effect. Perhaps, exploring the concept of nanotechnology in battling COVID 19 will ensure an excellent therapeutic prognosis. The review focus on emphasizing the need to explore the concept of nanotechnology as a gold possibility that could potentiate the world to win the fight against COVID -19.