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Hiroyuki Suzuki
Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Japan

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Clinical trial
Published: 25 November 2020 in Frontiers in Nutrition
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Background: To delay the onset of dementia, it is important for healthy adults to take preventive actions before the cognitive function clearly declines. Protein malnutrition is a potential risk factor for senile dementia, although the precise link between protein/amino acid nutrition and cognitive function is unknown. The purpose of this study was to examine the effect of the ingestion of seven selected essential amino acids as a granular powder, namely, leucine, phenylalanine, and lysine supplemented with isoleucine, histidine, valine, and tryptophan on cognitive and psychosocial functions in healthy adults.Methods: A double-blind, randomized, placebo-controlled trial was conducted. A total of 105 participants aged 55 years or older were randomly assigned to one of three groups: daily ingestion of 3 g (3gIG) or 6 g (6gIG) of the selected amino acids or daily ingestion of a placebo (PCG). Each group ingested the test powder for 12 weeks. As the main outcome, cognitive function was assessed before and after ingestion by a cognitive test battery. Psychosocial functions were also examined.Results: The numbers of participants excluding dropouts were 35 in PCG and 3gIG and 33 in 6gIG. Analysis of covariance revealed that the 6gIG showed significantly improved cognitive function (Trail Making Test B), social interaction and psychological health scores after ingestion compared to the PCG (multiplicity adjusted p < 0.05).Conclusions: Current findings suggested that ingestion of the seven essential amino acids led to improved attention and cognitive flexibility and psychosocial functioning, which is expected to prevent cognitive decline.Clinical Trial Registration: University Hospital Medical Information Network Clinical Trial Registry (URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000037779, Identifier: UMIN000033174).

ACS Style

Hiroyuki Suzuki; Daichi Yamashiro; Susumu Ogawa; Momoko Kobayashi; Daisuke Cho; Ai Iizuka; Masako Tsukamoto-Yasui; Michihiro Takada; Muneki Isokawa; Kenji Nagao; Yoshinori Fujiwara. Intake of Seven Essential Amino Acids Improves Cognitive Function and Psychological and Social Function in Middle-Aged and Older Adults: A Double-Blind, Randomized, Placebo-Controlled Trial. Frontiers in Nutrition 2020, 7, 1 .

AMA Style

Hiroyuki Suzuki, Daichi Yamashiro, Susumu Ogawa, Momoko Kobayashi, Daisuke Cho, Ai Iizuka, Masako Tsukamoto-Yasui, Michihiro Takada, Muneki Isokawa, Kenji Nagao, Yoshinori Fujiwara. Intake of Seven Essential Amino Acids Improves Cognitive Function and Psychological and Social Function in Middle-Aged and Older Adults: A Double-Blind, Randomized, Placebo-Controlled Trial. Frontiers in Nutrition. 2020; 7 ():1.

Chicago/Turabian Style

Hiroyuki Suzuki; Daichi Yamashiro; Susumu Ogawa; Momoko Kobayashi; Daisuke Cho; Ai Iizuka; Masako Tsukamoto-Yasui; Michihiro Takada; Muneki Isokawa; Kenji Nagao; Yoshinori Fujiwara. 2020. "Intake of Seven Essential Amino Acids Improves Cognitive Function and Psychological and Social Function in Middle-Aged and Older Adults: A Double-Blind, Randomized, Placebo-Controlled Trial." Frontiers in Nutrition 7, no. : 1.

Journal article
Published: 31 March 2020 in International Journal of Environmental Research and Public Health
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Recent research has suggested that the breadth and evenness of activity and activity diversity contribute to health outcomes among older adults. However, few established assessment tools for activity diversity have been developed. This study developed an Activity Diversity Questionnaire (ADQ) for older adults through expert consultation and a preliminary survey among 18 community-dwelling older adults. The diversity score was calculated according to Shannon’s entropy. In study 1, the intraclass correlation coefficients (ICC) of the diversity scores were determined for community-dwelling older adults (n = 30). In study 2, concurrent validity was tested with participants receiving comprehensive health checkups at the Itabashi ward in Japan in 2018 (n = 766). The correlation coefficients of the diversity scores were then calculated in reference to the Tokyo Metropolitan Institute of Gerontology Index of Competence and Japan Science and Technology Agency Index of Competence. The final version of the ADQ consisted of 20 total items with excellent test-retest reliability (ICC = 0.84) and moderate correlations with both the Tokyo Metropolitan Institute of Gerontology Index of Competence and Japan Science and Technology Agency Index of Competence (r = 0.48 and 0.60, respectively). The ADQ was developed through scientific procedures and revealed sufficient reliability and validity. As such, it is a scientifically validated tool for assessing activity diversity among older adults.

ACS Style

Junta Takahashi; Hisashi Kawai; Hiroyuki Suzuki; Yoshinori Fujiwara; Yutaka Watanabe; Hirohiko Hirano; Hunkyung Kim; Kazushige Ihara; Kaori Ishii; Koichiro Oka; Shuichi Obuchi. Reliability and Validity of the Activity Diversity Questionnaire for Older Adults in Japan. International Journal of Environmental Research and Public Health 2020, 17, 2384 .

AMA Style

Junta Takahashi, Hisashi Kawai, Hiroyuki Suzuki, Yoshinori Fujiwara, Yutaka Watanabe, Hirohiko Hirano, Hunkyung Kim, Kazushige Ihara, Kaori Ishii, Koichiro Oka, Shuichi Obuchi. Reliability and Validity of the Activity Diversity Questionnaire for Older Adults in Japan. International Journal of Environmental Research and Public Health. 2020; 17 (7):2384.

Chicago/Turabian Style

Junta Takahashi; Hisashi Kawai; Hiroyuki Suzuki; Yoshinori Fujiwara; Yutaka Watanabe; Hirohiko Hirano; Hunkyung Kim; Kazushige Ihara; Kaori Ishii; Koichiro Oka; Shuichi Obuchi. 2020. "Reliability and Validity of the Activity Diversity Questionnaire for Older Adults in Japan." International Journal of Environmental Research and Public Health 17, no. 7: 2384.

Journal article
Published: 24 August 2018 in BMC Geriatrics
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An association between handgrip strength, hand dexterity and global cognition is suggested; however, it is unclear whether both hand motor functions are associated with executive function, which is important for performing daily activities. Understanding this association will help identify motor risk factors for impairment of executive function in late adulthood. We aim to investigate the relationship of handgrip strength and hand dexterity with executive function in physically and mentally healthy community-dwelling older adults. Three hundred and twenty-six older adults (287 women, mean age ± SD, 70.1 ± 5.6) underwent handgrip strength and hand dexterity tests using a hand dynamometer and the Purdue Pegboard Test (PPT), respectively. Executive function was evaluated with the Trail Making Test (TMT)-A, TMT-B and Digit symbol; global cognition was assessed with the Mini-Mental State Examination (MMSE). Age-group differences showed that the younger groups (60-64, 65-69 and 70-74) had a significant better PPT and executive function performance than the oldest group (75 and older), whereas no significant age differences were observed for handgrip strength. Multiple regression analysis adjusted for potential covariates, including MMSE scores, showed that TMT-A, TMT-B, and Digit symbol were significantly associated with PPT scores; however, no significant association was observed between executive function variables and handgrip strength. Hand dexterity is vulnerable to the effects of aging and, contrary to handgrip strength, it strongly associates with executive function, independent of global cognition. Our results suggest that assessing hand dexterity may help identify individuals at higher risk of impairment of executive function among high-functioning older adults.

ACS Style

Kimi Estela Kobayashi-Cuya; Ryota Sakurai; Naoko Sakuma; Hiroyuki Suzuki; Masashi Yasunaga; Susumu Ogawa; Toru Takebayashi; Yoshinori Fujiwara. Hand dexterity, not handgrip strength, is associated with executive function in Japanese community-dwelling older adults: a cross-sectional study. BMC Geriatrics 2018, 18, 192 .

AMA Style

Kimi Estela Kobayashi-Cuya, Ryota Sakurai, Naoko Sakuma, Hiroyuki Suzuki, Masashi Yasunaga, Susumu Ogawa, Toru Takebayashi, Yoshinori Fujiwara. Hand dexterity, not handgrip strength, is associated with executive function in Japanese community-dwelling older adults: a cross-sectional study. BMC Geriatrics. 2018; 18 (1):192.

Chicago/Turabian Style

Kimi Estela Kobayashi-Cuya; Ryota Sakurai; Naoko Sakuma; Hiroyuki Suzuki; Masashi Yasunaga; Susumu Ogawa; Toru Takebayashi; Yoshinori Fujiwara. 2018. "Hand dexterity, not handgrip strength, is associated with executive function in Japanese community-dwelling older adults: a cross-sectional study." BMC Geriatrics 18, no. 1: 192.

Brief reports
Published: 27 August 2015 in Journal of the American Geriatrics Society
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Objectives To examine the distribution and associated predictors of 1‐year changes in the Japanese version of the Montreal Cognitive Assessment (MoCA‐J) in community‐dwelling older adults. Design Prospective cohort study. Setting Population‐based cohort study in Tokyo, Japan. Participants Individuals aged 65 to 84 (N = 496). Measurements Multinomial logistic regression analysis was performed to estimate the odds of experiencing subsequent improvement in MoCA‐J performance, as opposed to stable or deteriorating, while simultaneously adjusting for baseline MoCA‐J score and major confounders. Results Mean age was 74.0 ± 4.8; mean MoCA‐J score was 23.7 ± 3.6. Only 40% had stable MoCA‐J performance; 30% experienced deterioration and 30% improvement. Age increment, hospitalization in previous year, slower Timed Up and Go (TUG) score, and slower maximum walking speed were predictive of subsequent MoCA‐J performance deterioration. Conclusion Slower TUG and walking speed performances were independent predictors of short‐term MoCA‐J deterioration. Research aimed at assessing lower‐extremity performance‐based tests in MCI‐related decision‐making is warranted.

ACS Style

Hiroyuki Suzuki; Hisashi Kawai; Hirohiko Hirano; Hideyo Yoshida; Kazushige Ihara; Hunkyung Kim; Paulo H. M. Chaves; Ushio Minami; Masashi Yasunaga; Shuichi Obuchi; Yoshinori Fujiwara. One-Year Change in the Japanese Version of the Montreal Cognitive Assessment Performance and Related Predictors in Community-Dwelling Older Adults. Journal of the American Geriatrics Society 2015, 63, 1874 -1879.

AMA Style

Hiroyuki Suzuki, Hisashi Kawai, Hirohiko Hirano, Hideyo Yoshida, Kazushige Ihara, Hunkyung Kim, Paulo H. M. Chaves, Ushio Minami, Masashi Yasunaga, Shuichi Obuchi, Yoshinori Fujiwara. One-Year Change in the Japanese Version of the Montreal Cognitive Assessment Performance and Related Predictors in Community-Dwelling Older Adults. Journal of the American Geriatrics Society. 2015; 63 (9):1874-1879.

Chicago/Turabian Style

Hiroyuki Suzuki; Hisashi Kawai; Hirohiko Hirano; Hideyo Yoshida; Kazushige Ihara; Hunkyung Kim; Paulo H. M. Chaves; Ushio Minami; Masashi Yasunaga; Shuichi Obuchi; Yoshinori Fujiwara. 2015. "One-Year Change in the Japanese Version of the Montreal Cognitive Assessment Performance and Related Predictors in Community-Dwelling Older Adults." Journal of the American Geriatrics Society 63, no. 9: 1874-1879.

Randomized controlled trial
Published: 21 November 2014 in BMC Geriatrics
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Non-pharmacological interventions are expected to be important strategies for reducing the age-adjusted prevalence of senile dementia, considering that complete medical treatment for cognitive decline has not yet been developed. From the viewpoint of long-term continuity of activity, it is necessary to develop various cognitive stimulating programs. The aim of this study is to examine the effectiveness of a cognitive intervention through a training program for picture book reading for community-dwelling older adults. Fifty-eight Japanese older participants were divided into the intervention and control groups using simple randomization (n =29 vs 29). In the intervention group, participants took part in a program aimed at learning and mastering methods of picture book reading as a form of cognitive training intervention. The control group listened to lectures about elderly health maintenance. Cognitive tests were conducted individually before and after the programs. The rate of memory retention, computed by dividing Logical Memory delayed recall by immediate recall, showed a significant interaction (p < .05) in analysis of covariance. Simple main effects showed that the rate of memory retention of the intervention group improved after the program completion (p < .05). In the participants with mild cognitive impairment (MCI) examined by Japanese version of the Montreal Cognitive Assessment (MoCA-J) (n =14 vs 15), significant interactions were seen in Trail Making Test-A (p < .01), Trail Making Test-B (p < .05), Kana pick-out test (p < .05) and the Mini-Mental State Examination (p < .05). The intervention effect was found in delayed verbal memory. This program is also effective for improving attention and executive function in those with MCI. The short-term interventional findings suggest that this program might contribute to preventing a decline in memory and executive function. UMIN000014712 (Date of ICMJE and WHO compliant trial information disclosure: 30 July 2014).

ACS Style

Hiroyuki Suzuki; Masataka Kuraoka; Masashi Yasunaga; Kumiko Nonaka; Ryota Sakurai; Rumi Takeuchi; Yoh Murayama; Hiromi Ohba; Yoshinori Fujiwara. Cognitive intervention through a training program for picture book reading in community-dwelling older adults: a randomized controlled trial. BMC Geriatrics 2014, 14, 122 .

AMA Style

Hiroyuki Suzuki, Masataka Kuraoka, Masashi Yasunaga, Kumiko Nonaka, Ryota Sakurai, Rumi Takeuchi, Yoh Murayama, Hiromi Ohba, Yoshinori Fujiwara. Cognitive intervention through a training program for picture book reading in community-dwelling older adults: a randomized controlled trial. BMC Geriatrics. 2014; 14 (1):122.

Chicago/Turabian Style

Hiroyuki Suzuki; Masataka Kuraoka; Masashi Yasunaga; Kumiko Nonaka; Ryota Sakurai; Rumi Takeuchi; Yoh Murayama; Hiromi Ohba; Yoshinori Fujiwara. 2014. "Cognitive intervention through a training program for picture book reading in community-dwelling older adults: a randomized controlled trial." BMC Geriatrics 14, no. 1: 122.