The encouraging Design for Disassembly appears in the literature more and more often. Such a design appears to offer clear environmental advantages. However, there are still not enough research results to support the existence of these benefits. The authors using the Life Cycle Assessment method, which assesses the energy consumption and greenhouse gas emissions during the demolition and operation of steel structure. Steel is completely recyclable and, in terms of tonnage, is the most recycled material worldwide. We assessed three scenarios: (1) complete re-remelting (recycling) of the structure; (2) partial reuse of construction elements + remelting (recovery + recycling); and (3) complete reuse of the structure (recovery). GaBi software was used for the analysis. It was found that the environmental impact varied significantly among the examined scenarios. The first scenario poses the greatest environmental burden. However, compared to Scenario no. 1, Scenario 3’s environmental impact is more than 70% lower.

This paper aims to conceptualise the construction of noise barrier panels from components recovered from used wind turbine propellers. At present, they are mainly waste, but many ideas for their reuse are emerging. Based on previously conducted material tests, the strength of the panels was calculated in accordance with EN 14388. The finite element method and the ANSYS space-claim programme were used to analyse the strength and generate a 3D numerical model of the cracked wind turbine propeller panels. The permissible values given in the standard were compared with those obtained for the deflection of the component.

The paper aims to examine the possibility of adapting an existing school building to the standard of a zero energy building. The school building is a specific case of a building in which the energy consumption is periodic, except for the months with the most sunshine. Therefore, it is necessary to look for a solution that will allow storing the energy obtained, for example, from solar collectors. Based on the analysis of the literature, it was concluded that the use of borehole thermal energy storage might be the right solution to the problem. The article presents the energy balance of the building with and without the use of renewable energy sources and the benefits of using an energy storage system.

The Apolipoprotein-E4 allele (APOE) is the strongest genetic risk factor for sporadic Alzheimer’s disease but its role in disease pathogenesis is incompletely understood. The APOE gene encodes Apolipoprotein E (ApoE). Astrocytes are the main source of ApoE in the central nervous system (CNS) and are essential for homeostasis in health and disease. In response to CNS insult, a coordinated multicellular inflammatory response is triggered causing reactive astrogliosis with changes in astrocytic gene expression, cellular structure and function. Human embryonic stem-cells with the ‘neutral’ APOE33 genotype were edited using CRISPR Cas-9 gene-editing to create isogenic APOE lines with an APOE44 genotype. Quiescent astrocytes were differentiated then stimulated with TNF-α, IL1α and C1q inducing an astrogliotic A1 phenotype. Several potentially pathological APOE44 -related phenotypes were identified in both quiescent cells and reactive A1 astrocytes including significantly decreased phagocytosis, impaired glutamate and a defective immunomodulatory response. In quiescent APOE44 astrocytes there was significantly decreased secretion of IL6, IL8 and several oxylipins. In A1 astrocytes there was a pro-inflammatory phenotype in APOE44 astrocytes with increases in GRO, ENA78, IL6 and IL8, a decrease in IL10 as well as significant differences in oxylipin expression. As TNF-α induced signaling in astrocytes is driven by Nuclear factor kappa B (NF-κB) proteins of this pathway were measured. Significantly higher levels of the p50, p65 and IκBα sub-units were found in both quiescent and A1 APOE44 astrocytes. This suggests that perturbation of NF-κB signaling may contribute to the damaging APOE44 cell phenotypes observed providing a new direction for targeted disease therapeutics.

In this study, the idea of an energy self-sufficient public utility building was presented, as well as its energy balance components and the possibility of powering it with renewable sources. The annual energy consumption profile of the building was analyzed. Current data concerning the production of electricity from Renewable Energy Systems (RES) were presented. The applicable provisions of the Directive of the European Parliament and the EU Council on energy efficiency were discussed.