Nowadays, autograft and allograft techniques represent the main solution to improve bone repair. Unfortunately, autograft technique is expensive, invasive and subject to infections and hematoma, frequently affecting both donor sites and surgical sites. A recent advance in tissue engineering is the fabrication of cell-laden hydrogels with custom-made geometry, depending on the clinical case. The use of ECM (Extra-Cellular Matrix)-derived Hydrogels from bone tissue is the new opportunity to obtain good results in bone regeneration.

Skin regeneration is a multidisciplinary topic that involves plastic surgery, aesthetics, and dermatology. In the last few years, several molecules have been used to prevent or delay the skin aging process. Recently, promising investigations on novel β-1,3/1,6-glucan-based treatments, associated with sodium hyaluronate, have demonstrated the induction of a naïve biological stimulus in soft tissues. Serum Revitalizing Face (Lot 00118a0051 of 11/19/2018 approved by the Italian Ministry of Health as a Medical Device-Class I) was administered mainly on the face and forearms of the enrolled patients. The Serum Revitalizing Face was administered at T0 (first week), T1 (second week), and T2 (third week). Patients were asked to apply 1.5 mL of the serum on their skin until the product was completely absorbed. All patients were also examined by clinical assessments at different time points. The results showed that a daily application of the β-1,3/1,6-glucan induced a statistically significant increase in the elasticity of the skin.