A specialist in cardiovascular disease by training, Isabelle Mahé is a Professor of Internal Medicine at Université Paris Cité. She is Head of the Internal Medicine Department at a teaching hospital (Louis Mourier, Assistance Publique Hôpitaux de Paris, Colombes, France), which includes an oncology unit and a vascular disease unit. She set up a tele-expertise service to help physicians manage patients with anticoagulant concerns. She is also chair of the scientific council for the INNOVTE-FCRIN Network (Investigation Network On Venous Thromboembolism) and for a patient association taking anticoagulant (Anticoag PASS S2D). She has broad experience in methodology and in clinical trials evaluating anticoagulants in different cardiological or vascular settings. Her own research projects have resulted in a better management of anticoagulants in complex patients (renally impaired, elderly and cancer patients). She leads the international prospective randomised API-CAT Study (focusing on the extended anticoagulant treatment in patients with cancer-associated thrombosis).