For the last three decades, the predominant subject of my work, although not exclusively, has been the Bluetongue Virus (BTV), a complex layered virus that is a member of the Reoviridae family. I have made significant contributions to understanding the basic molecular and cell biology, atomic structure, mechanisms of virus entry, genome synthesis, RNA packaging, capsid assembly, egress and cell-to cell transmission of these viruses. Through multi-disciplinary approach and comprehensive research coverage has led to the successful development of improved diagnostic assays, more efficacious VLP vaccines, alternative Entry Competent Replication Abortive vaccine (ECRA) for BTV and African Horse sickness viruses (AHSV) and alternative therapeutic possibilities.. Further, through appropriate collaborations, high-resolution cryoEM structures of complete virus particles, individual proteins, sub-virus assemblies and viral tubules were obtained over the years.