Introduction The effects of imageability and familiarity on lexical access have received attention in many languages and in people with aphasia. However, its effect on Malay-speaking individuals with or without aphasia has not been comprehensively addressed. This study aims to investigate comprehension of nouns and verbs in Malay-speaking adults with aphasia and the effect of imagebility and familiarity on comprehension of both word classes. Methods The performance of two groups of participants; control subjects and subject with aphasia were assessed via picture verification task. 14 Malay-speaking adults with aphasia, aged 28-64 years old (mean=50.70) and 20 control subjects with age-, gender- and education-matched, 28-71 years old (mean= 52.29) native speakers of Malay were recruited. 52 nouns and 32 verbs which were controlled for word length, imageability and familiarity were elicited and converted to black and white picture cards. The subjects were asked to judge by saying ‘yes’ or ‘no’ whether the spoken words were the correct name for the picture shown. If the subjects had difficulties speaking, they could point to the yes/no card provided in front of them. Results ANOVA comparing the group of control subjects and people with aphasia (fluent and non-fluent) showed a significant difference between the groups (F(1,32)=14.50, p<0.05), a difference between nouns and verbs (F(1,32 )=24.28, p<0.05), but no significant interaction (F(1,32)=2.82, p=0.10), showing that, as a group, people with aphasia showed poorer performance with verbs than nouns relative to control subjects. When comparing the groups of fluent and non-fluent aphasia, there was a significant main effect of group (F(1,18) = 11.32, p<0.05), reflecting the much better comprehension of both classes of words by people with fluent aphasia. There was a significant main effect of word classes (F(1,18) = 13.54, p<0.05), because the subjects in both groups were less accurate with nouns than verbs. The interaction of group and word class was not significant (F(1,18)=0.27, p=0.61), indicating that the two groups showed a broadly equivalent degree of difficulty with verbs relative to nouns. When simultaneous regression is used, looking for the effects of an independent effect of a variable independent of the effects of the other (potentially-confounded) effects of independent variables, there is no significant independent effect of any variable used in this study on subject’s comprehension performance. A further analysis used logistic regression for each of these variables separately to predict participants’ accuracy in comprehension. Four subjects with aphasia show a significant difference between nouns and verbs but it is noteworthy that all of these subjects also show effects of imageability and only one subject shows familiarity effect, but when the effects of these confounding variables are taken into account, these differences between nouns and verbs are no longer significant. Conclusion This study highlights comprehension of verbs was found to be more difficult than nouns in Malay-speaking adults with aphasia. There was no effect of imageability and familiarity on nouns and verbs comprehension in the group of aphasia subjects when both confounding variables were taken into account.