Claire H. Mitchell received her B.Sc. in Biology from McGill University, Canada in 1986 and her Ph.D. in Physiology from University College London, UK in 1994. As Director of the Vision Research Center at the University of Pennsylvania, Dr. Mitchell provides guidance to support the integration and development of vision research across the university. She also serves as Director of DScD Curriculum and Training, helping students to integrate their clinical and research training. Her own research investigates the mechanistic steps leading to age-dependent neurodegenerations and identifies novel treatments for these diseases. For example, her lab is currently investigating how mechanical strain modifies interactions between astrocytes and microglial cells and can damage neurons. The project is focused on ATP released via Piezo and pannexin hemichannels, P2X7 receptors, and how this activates the NLRP3 inflammasome and cytokine release. In addition, the lab is exploring the physiology of lysosomes, with investigations into how lysosomal pH is regulated in health and disease. Pharmacological and molecular manipulation of lysosomal channels such as TRPML1 and reacidifying nanoparticle treatment is used to enhance lysosomal function and improve degradative activity in ageing and diseased cells.