In this paper, we propose an adaptive entropy model (AEM), which incorporates the entropy measurement and the adaptability into the conventional Markowitz’s mean-variance model (MVM). We evaluate the performance of AEM, based on several portfolio performance indicators using the five-year Shanghai Stock Exchange 50 (SSE50) index constituent stocks data set. Our outcomes show, compared with the traditional portfolio selection model, that AEM tends to make our investments more decentralized and hence helps to neutralize unsystematic risks. Due to the existence of self-adaptation, AEM turns out to be more adaptable to market fluctuations and helps to maintain the balance between the decentralized and concentrated investments in order to meet investors’ expectations. Our model applies equally well to portfolio optimizations for other financial markets.