Guglielmo Lanzani

Guglielmo Lanzani

orcid

Research Focus & Metrics

Academic Career Length

37Years (1990-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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17 March 2013 in Nature Photonics
Verified
Journal Article
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DGDiego Ghezzi
Diego Ghezzi
MAMaria Rosa Antognazza
Maria Rosa Antognazza
Rita MaccaroneRita Maccarone
Rita Maccarone
SBSebastiano Bellani
Sebastiano Bellani
ELErica Lanzarini
Erica Lanzarini
FBFabio Benfenati
Fabio Benfenati
Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in several applications, including cellular scaffolds, neural probes, biosensors and actuators for drug release. Recently, an organic photovoltaic blend has been used for neuronal stimulation via a photo-excitation process. Here, we document the use of a single-component organic film of poly(3-hexylthiophene) (P3HT) to trigger neuronal firing upon illumination. Moreover, we demonstrate that this bio–organic interface restores light sensitivity in explants of rat retinas with light-induced photoreceptor degeneration. These findings suggest that all-organic devices may play an important future role in subretinal prosthetic implants.

29 June 2020 in Nature Nanotechnology
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Journal Article
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JMJosé Fernando Maya-Vetencourt
José Fernando Maya-Vetencourt
GMGiovanni Manfredi
Giovanni Manfredi
MMMaurizio Mete
Maurizio Mete
ECElisabetta Colombo
Elisabetta Colombo
Mattia BraminiMattia Bramini
Mattia Bramini
FBFabio Benfenati
Fabio Benfenati
Inherited retinal dystrophies and late-stage age-related macular degeneration, for which treatments remain limited, are among the most prevalent causes of legal blindness. Retinal prostheses have been developed to stimulate the inner retinal network; however, lack of sensitivity and resolution, and the need for wiring or external cameras, have limited their application. Here we show that conjugated polymer nanoparticles (P3HT NPs) mediate light-evoked stimulation of retinal neurons and persistently rescue visual functions when subretinally injected in a rat model of retinitis pigmentosa. P3HT NPs spread out over the entire subretinal space and promote light-dependent activation of spared inner retinal neurons, recovering subcortical, cortical and behavioural visual responses in the absence of trophic effects or retinal inflammation. By conferring sustained light sensitivity to degenerate retinas after a single injection, and with the potential for high spatial resolution, P3HT NPs provide a new avenue in retinal prosthetics with potential applications not only in retinitis pigmentosa, but also in age-related macular degeneration.

20 April 2011 in The Journal of Physical Chemistry Letters
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Journal Article
Closed access
Giulia GranciniGiulia Grancini
Giulia Grancini
Dario PolliDario Polli
Dario Polli
Daniele FazziDaniele Fazzi
Daniele Fazzi
JGJuan Cabanillas Gonzalez
Juan Cabanillas Gonzalez
Giulio CerulloGiulio Cerullo
Giulio Cerullo
GLGuglielmo Lanzani
Guglielmo Lanzani

10 March 2015 in Scientific Reports
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Journal Article
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NMNicola Martino
Nicola Martino
PFPaul Feyen
Paul Feyen
MPMatteo Porro
Matteo Porro
CBCaterina Bossio
Caterina Bossio
EZElena Zucchetti
Elena Zucchetti
MAMaria Rosa Antognazza
Maria Rosa Antognazza
Hybrid interfaces between organic semiconductors and living tissues represent a new tool for in-vitro and in-vivo applications, bearing a huge potential, from basic researches to clinical applications. In particular, light sensitive conjugated polymers can be exploited as a new approach for optical modulation of cellular activity. In this work we focus on light-induced changes in the membrane potential of Human Embryonic Kidney (HEK-293) cells grown on top of a poly(3-hexylthiophene) (P3HT) thin film. On top of a capacitive charging of the polymer interface, we identify and fully characterize two concomitant mechanisms, leading to membrane depolarization and hyperpolarisation, both mediated by a thermal effect. Our results can be usefully exploited in the creation of a new platform for light-controlled cell manipulation, with possible applications in neuroscience and medicine.

20 February 2018 in Advanced Materials
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GBGiorgio E. Bonacchini
Giorgio E. Bonacchini
CBCaterina Bossio
Caterina Bossio
FGFrancesco Greco
Francesco Greco
Virgilio MattoliVirgilio Mattoli
Virgilio Mattoli
YKYun‐Hi Kim
Yun‐Hi Kim
MCMario Caironi
Mario Caironi

3 February 2020 in Nature Nanotechnology
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Journal Article
Closed access
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MDMattia Lorenzo Difrancesco
Mattia Lorenzo Difrancesco
FLFrancesco Lodola
Francesco Lodola
ECElisabetta Colombo
Elisabetta Colombo
LMLuca Maragliano
Luca Maragliano
Mattia BraminiMattia Bramini
Mattia Bramini
FBFabio Benfenati
Fabio Benfenati