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Dr. Manuela Correia
REQUIMTE/LAQV, Instituto Superior de Engenharia do Porto, Politécnico do Porto, 4249-015 Porto, Portugal

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0 Analytical Chemistry
0 Chromatography
0 Environmental Chemistry
0 Food Safety
0 Pharmaceuticals

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pesticides
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Journal article
Published: 12 July 2021 in Applied Sciences
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The scientific community is increasingly concerned about the presence of pharmaceuticals in the aquatic environment, which is a consequence of their high consumption and inefficient removal by wastewater-treatment plants. The search for an effective and sustainable tertiary treatment is therefore needed to enhance their removal. For this purpose, the combination of electrochemical and adsorption processes into three-dimensional (3D) electrochemical systems has been proposed. In this study, a 3D system was studied to remove carbamazepine, an antiepileptic, consumed in high doses and very persistent in the environment. The influences of the following parameters on its removal were evaluated: anode and cathode materials and distance between them, electrolyte (NaCl) concentration and pH, and the (carbon-based) adsorbent material used as the particulate electrode. The obtained results demonstrated that the introduction of the particulate electrode improved the removal efficiency. This can be attributed to the simultaneous occurrence of different phenomena, such as adsorption/electrosorption, electrocoagulation, oxidation, and catalytic degradation.

ACS Style

Luísa Correia-Sá; Cristina Soares; Olga Freitas; Manuela Moreira; Henri Nouws; Manuela Correia; Paula Paíga; António Rodrigues; Carlos Oliveira; Sónia Figueiredo; Cristina Delerue-Matos. A Three-Dimensional Electrochemical Process for the Removal of Carbamazepine. Applied Sciences 2021, 11, 6432 .

AMA Style

Luísa Correia-Sá, Cristina Soares, Olga Freitas, Manuela Moreira, Henri Nouws, Manuela Correia, Paula Paíga, António Rodrigues, Carlos Oliveira, Sónia Figueiredo, Cristina Delerue-Matos. A Three-Dimensional Electrochemical Process for the Removal of Carbamazepine. Applied Sciences. 2021; 11 (14):6432.

Chicago/Turabian Style

Luísa Correia-Sá; Cristina Soares; Olga Freitas; Manuela Moreira; Henri Nouws; Manuela Correia; Paula Paíga; António Rodrigues; Carlos Oliveira; Sónia Figueiredo; Cristina Delerue-Matos. 2021. "A Three-Dimensional Electrochemical Process for the Removal of Carbamazepine." Applied Sciences 11, no. 14: 6432.

Journal article
Published: 12 June 2021 in Foods
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The total lipid content and lipidic profile of seaweeds harvested in the North Coast and purchased in Portugal were determined in this paper. The amount of total lipids in the different species of seaweeds varied between 0.7 ± 0.1% (Chondrus crispus) and 3.8 ± 0.6% (Ulva spp.). Regarding the fatty acid content, polyunsaturated fatty acids (PUFA) ranged between 0–35%, with Ulva spp. presenting the highest amount; monounsaturated fatty acids (MUFA) varied between 19 and 67%; and saturated fatty acids (SFA) were predominant in C. crispus (45–78%) and Gracilaria spp. (36–79%). Concerning the nutritional indices, the atherogenicity index (AI) was between 0.4–3.2, the thrombogenicity index (TI) ranged from 0.04 to 1.95, except for Gracilaria spp., which had a TI of 7.6, and the hypocholesterolemic/hypercholesterolemic ratio (HH) values ranged between 0.88–4.21, except for Gracilaria spp., which exhibited values between 0.22–9.26. The n6/n3 ratio was below 1 for most of the species evaluated, except for Ascophyllum nodosum, which presented a higher value, although below 2. Considering the PUFA/SFA ratio, seaweeds presented values between 0.11–1.02. The polycyclic aromatic hydrocarbons (PAHs) and aliphatic hydrocarbons (AHCs) contamination of seaweeds under study was also quantified, the values found being much lower than the maximum levels recommended for foodstuff.

ACS Style

Cristina Soares; Sara Sousa; Susana Machado; Elsa Vieira; Ana Carvalho; Maria Ramalhosa; Simone Morais; Manuela Correia; Teresa Oliva-Teles; Valentina Domingues; Cristina Delerue-Matos. Bioactive Lipids of Seaweeds from the Portuguese North Coast: Health Benefits versus Potential Contamination. Foods 2021, 10, 1366 .

AMA Style

Cristina Soares, Sara Sousa, Susana Machado, Elsa Vieira, Ana Carvalho, Maria Ramalhosa, Simone Morais, Manuela Correia, Teresa Oliva-Teles, Valentina Domingues, Cristina Delerue-Matos. Bioactive Lipids of Seaweeds from the Portuguese North Coast: Health Benefits versus Potential Contamination. Foods. 2021; 10 (6):1366.

Chicago/Turabian Style

Cristina Soares; Sara Sousa; Susana Machado; Elsa Vieira; Ana Carvalho; Maria Ramalhosa; Simone Morais; Manuela Correia; Teresa Oliva-Teles; Valentina Domingues; Cristina Delerue-Matos. 2021. "Bioactive Lipids of Seaweeds from the Portuguese North Coast: Health Benefits versus Potential Contamination." Foods 10, no. 6: 1366.

Journal article
Published: 25 March 2021 in Sustainability
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Several pesticides and pharmaceuticals (PP) have been detected in the effluent of a full-scale Portuguese Wastewater Treatment Plant (WWTP). Their presence contributed to the environmental burdens associated with the existing treatment of the Municipal Wastewater (MWW) in the impact categories of Human Carcinogenicity, Non-Carcinogenicity, and Freshwater toxicities on average by 85%, 60%, and 90%, respectively (ReciPe2016 and USEtox methods). The environmental and economic assessment of the installation of an Anodic Oxidation (AO) unit for PPs’ removal was performed through Life Cycle and Economic Analysis, considering two types of anodes, the Boron-Doped Diamond (BDD) and the Mixed Metal Oxides (MMO). The operation of the AO unit increased the environmental burdens of the system by 95% on average (USEtox), but these impacts can be partially compensated by the avoided the production of non-renewable energy in the Portuguese electricity mix by biogas cogeneration at the WWTP. If the construction of the AO unit and the manufacturing of the electrodes are considered, the Human and Freshwater Toxicities are often higher than the environmental benefits derived from the PPs’ removal. On the economic side, the MMO configuration is clearly more advantageous, whereas BDD is environmentally more favorable. The issue of the presence of PP in MWW effluents has to be addressed as an integrated solution both improving upstream PP’s management and adopting PP’s removal technologies strongly supported by renewable energies. Further insights are needed for the assessment of fate and of the environmental effects of PP in the sludge.

ACS Style

Elena Surra; Manuela Correia; Sónia Figueiredo; Jaime Silva; Joana Vieira; Sandra Jorge; Marta Pazos; Maria Sanromán; Nuno Lapa; Cristina Delerue-Matos. Life Cycle and Economic Analyses of the Removal of Pesticides and Pharmaceuticals from Municipal Wastewater by Anodic Oxidation. Sustainability 2021, 13, 3669 .

AMA Style

Elena Surra, Manuela Correia, Sónia Figueiredo, Jaime Silva, Joana Vieira, Sandra Jorge, Marta Pazos, Maria Sanromán, Nuno Lapa, Cristina Delerue-Matos. Life Cycle and Economic Analyses of the Removal of Pesticides and Pharmaceuticals from Municipal Wastewater by Anodic Oxidation. Sustainability. 2021; 13 (7):3669.

Chicago/Turabian Style

Elena Surra; Manuela Correia; Sónia Figueiredo; Jaime Silva; Joana Vieira; Sandra Jorge; Marta Pazos; Maria Sanromán; Nuno Lapa; Cristina Delerue-Matos. 2021. "Life Cycle and Economic Analyses of the Removal of Pesticides and Pharmaceuticals from Municipal Wastewater by Anodic Oxidation." Sustainability 13, no. 7: 3669.

Erratum
Published: 01 July 2020 in Science of The Total Environment
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Paula Paíga; Manuela Correia; Maria João Fernandes; Ana Silva; Manuela Carvalho; Joana Vieira; Sandra Jorge; Jaime Gabriel Silva; Cristina Freire; Cristina Delerue-Matos. Corrigendum to “Assessment of 83 pharmaceuticals in WWTP influent and effluent samples by UHPLC-MS/MS: Hourly variation” [Sci. Total Environ. 648 (2019) 582–600]. Science of The Total Environment 2020, 737, 140484 .

AMA Style

Paula Paíga, Manuela Correia, Maria João Fernandes, Ana Silva, Manuela Carvalho, Joana Vieira, Sandra Jorge, Jaime Gabriel Silva, Cristina Freire, Cristina Delerue-Matos. Corrigendum to “Assessment of 83 pharmaceuticals in WWTP influent and effluent samples by UHPLC-MS/MS: Hourly variation” [Sci. Total Environ. 648 (2019) 582–600]. Science of The Total Environment. 2020; 737 ():140484.

Chicago/Turabian Style

Paula Paíga; Manuela Correia; Maria João Fernandes; Ana Silva; Manuela Carvalho; Joana Vieira; Sandra Jorge; Jaime Gabriel Silva; Cristina Freire; Cristina Delerue-Matos. 2020. "Corrigendum to “Assessment of 83 pharmaceuticals in WWTP influent and effluent samples by UHPLC-MS/MS: Hourly variation” [Sci. Total Environ. 648 (2019) 582–600]." Science of The Total Environment 737, no. : 140484.

Journal article
Published: 03 March 2020 in Molecules
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This study aimed to develop new canned chub mackerel products incorporating edible seaweeds (Ascophyllum nodosum, Fucus spiralis, Saccorhiza polyschides, Chondrus crispus, Porphyra sp. and Ulva sp.) harvested in the Portuguese North-Central coast, with simultaneous sensory improvement and minerals enrichment. Two processes were compared, namely the addition of seaweeds in i) the canning step and ii) in the brining step (as the replacement for salt). The concentrations of four macrominerals (Na, K, Ca and Mg), chloride, and twelve trace elements (Co, Cu, Fe, I, Li, Mn, Mo, Rb, Se, Sr, V and Zn) were determined by high-resolution continuum source flame atomic absorption spectrometry (HR-CS-FAAS) and inductively coupled plasma mass spectrometry (ICP-MS), respectively. Results showed that canned chub mackerel incorporating C. crispus and F. spiralis was found to be the preferred sensory option, also exhibiting contents enriched with Cl, Co, Cu, Fe, I, Li, Mg, Mn, Mo, Na, Rb, Se, and Sr. This effect was more pronounced when both seaweed species were added to replace the salt added in the brining step.

ACS Style

Elsa F. Vieira; Cristina Soares; Susana Machado; M. Teresa Oliva-Teles; Manuela Correia; Maria João Ramalhosa; Ana Carvalho; Valentina F. Domingues; Filipa Antunes; Simone Morais; Cristina Delerue-Matos. Development of New Canned Chub Mackerel Products Incorporating Edible Seaweeds—Influence on the Minerals and Trace Elements Composition. Molecules 2020, 25, 1133 .

AMA Style

Elsa F. Vieira, Cristina Soares, Susana Machado, M. Teresa Oliva-Teles, Manuela Correia, Maria João Ramalhosa, Ana Carvalho, Valentina F. Domingues, Filipa Antunes, Simone Morais, Cristina Delerue-Matos. Development of New Canned Chub Mackerel Products Incorporating Edible Seaweeds—Influence on the Minerals and Trace Elements Composition. Molecules. 2020; 25 (5):1133.

Chicago/Turabian Style

Elsa F. Vieira; Cristina Soares; Susana Machado; M. Teresa Oliva-Teles; Manuela Correia; Maria João Ramalhosa; Ana Carvalho; Valentina F. Domingues; Filipa Antunes; Simone Morais; Cristina Delerue-Matos. 2020. "Development of New Canned Chub Mackerel Products Incorporating Edible Seaweeds—Influence on the Minerals and Trace Elements Composition." Molecules 25, no. 5: 1133.

Book chapter
Published: 22 February 2019 in Bottled and Packaged Water
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To best meet the consumer’s preferences, the beverages industry has been developing new nonalcoholic drinks. Actually, the drink production business has been focused on providing appealing (i.e., pleasant taste and aroma), high quality, and safe products to satisfy the increasing consumer demand for safety and nutritional excellence. Moreover, it is becoming increasingly clear that some drink components, for example, bioactive compounds, may be protective in some diseases caused by oxidative damage. Thus, there is a need to understand the physiological importance of bioactive compounds and also to know their amount and composition in different types of drinks. Considering this important issue, the purpose of this chapter is to review the characterization of bioactive compounds in flavored waters and fruit juices. Furthermore, it is also intended to describe selective assays for bioactive compounds assessment, such as spectrophotometric, DNA-based sensors, and chromatographic methods.

ACS Style

M. Fátima Barroso; Ana P. Carvalho; Manuela Correia; M.J. Ramalhosa; Cristina Delerue-Matos; Clara Grosso. Characterization of Bioactive Compounds in Flavored Waters and Fruit Juices. Bottled and Packaged Water 2019, 311 -366.

AMA Style

M. Fátima Barroso, Ana P. Carvalho, Manuela Correia, M.J. Ramalhosa, Cristina Delerue-Matos, Clara Grosso. Characterization of Bioactive Compounds in Flavored Waters and Fruit Juices. Bottled and Packaged Water. 2019; ():311-366.

Chicago/Turabian Style

M. Fátima Barroso; Ana P. Carvalho; Manuela Correia; M.J. Ramalhosa; Cristina Delerue-Matos; Clara Grosso. 2019. "Characterization of Bioactive Compounds in Flavored Waters and Fruit Juices." Bottled and Packaged Water , no. : 311-366.

Journal article
Published: 01 December 2018 in Food Chemistry
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The total protein content and the (total and free) amino acid composition of nine edible species of red, brown and green seaweeds collected in the Portuguese North-Central coast were quantified to assess their potential contribution to the recommended dietary intake. Whenever possible, the protein and amino acid composition was compared with that of commercial European seaweeds. The protein content was the highest (P<0.05) in red species (19.1-28.2 g/100g dw), followed by the green seaweed Ulva spp. (20.5-23.3 g/100g dw), with the lowest content found in brown seaweeds (6.90-19.5 g/100g dw). Brown seaweeds presented the lowest mean contents of essential amino acids (EAAs) (41.0% protein) but significantly (P<0.05) higher concentrations of non-essential amino acids (36.1% protein) and free amino acids (6.47-24.0% protein). Tryptophan, methionine and leucine were the limiting EAAs in all species. In contrast, lysine was found in high concentrations, especially in red (2.71-3.85% protein) and green (2.84-4.24% protein) seaweeds.

ACS Style

Elsa Ferreira Vieira; Cristina Soares; Susana Machado; Manuela Correia; Maria João Ramalhosa; Maria Teresa Oliva-Teles; Ana Carvalho; Valentina Domingues; Filipa Antunes; Teresa Azevedo Cardoso Oliveira; Simone Morais; Cristina Delerue-Matos. Seaweeds from the Portuguese coast as a source of proteinaceous material: Total and free amino acid composition profile. Food Chemistry 2018, 269, 264 -275.

AMA Style

Elsa Ferreira Vieira, Cristina Soares, Susana Machado, Manuela Correia, Maria João Ramalhosa, Maria Teresa Oliva-Teles, Ana Carvalho, Valentina Domingues, Filipa Antunes, Teresa Azevedo Cardoso Oliveira, Simone Morais, Cristina Delerue-Matos. Seaweeds from the Portuguese coast as a source of proteinaceous material: Total and free amino acid composition profile. Food Chemistry. 2018; 269 ():264-275.

Chicago/Turabian Style

Elsa Ferreira Vieira; Cristina Soares; Susana Machado; Manuela Correia; Maria João Ramalhosa; Maria Teresa Oliva-Teles; Ana Carvalho; Valentina Domingues; Filipa Antunes; Teresa Azevedo Cardoso Oliveira; Simone Morais; Cristina Delerue-Matos. 2018. "Seaweeds from the Portuguese coast as a source of proteinaceous material: Total and free amino acid composition profile." Food Chemistry 269, no. : 264-275.

Journal article
Published: 10 August 2018 in Science of The Total Environment
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The removal efficiency of pharmaceuticals in wastewater treatment plants (WWTPs) is variable and some of these compounds pass these plants almost intact and others presenting a removal efficiency close to 100%. Their incomplete removal results in a continuous discharge of pharmaceuticals into the environment. To assess the profile of contamination of influents and effluents over a day, a set of 83 pharmaceuticals were evaluated hourly in a WWTP in Leiria, Portugal. The composite samples of the influent and effluent were also collected. Concentrations varied from 1 in WWTP influents, and carbamazepine, fluoxetine, sertraline the pharmaceuticals with an RQ > 1 in WWTP effluents.

ACS Style

Paula Paíga; Manuela Correia; Maria João Fernandes; Ana Silva; Maria Manuela Martins de Carvalho; Joana Vieira; Sandra Jorge; Jaime Gabriel Silva; Cristina Freire; Cristina Delerue-Matos. Assessment of 83 pharmaceuticals in WWTP influent and effluent samples by UHPLC-MS/MS: Hourly variation. Science of The Total Environment 2018, 648, 582 -600.

AMA Style

Paula Paíga, Manuela Correia, Maria João Fernandes, Ana Silva, Maria Manuela Martins de Carvalho, Joana Vieira, Sandra Jorge, Jaime Gabriel Silva, Cristina Freire, Cristina Delerue-Matos. Assessment of 83 pharmaceuticals in WWTP influent and effluent samples by UHPLC-MS/MS: Hourly variation. Science of The Total Environment. 2018; 648 ():582-600.

Chicago/Turabian Style

Paula Paíga; Manuela Correia; Maria João Fernandes; Ana Silva; Maria Manuela Martins de Carvalho; Joana Vieira; Sandra Jorge; Jaime Gabriel Silva; Cristina Freire; Cristina Delerue-Matos. 2018. "Assessment of 83 pharmaceuticals in WWTP influent and effluent samples by UHPLC-MS/MS: Hourly variation." Science of The Total Environment 648, no. : 582-600.

Journal article
Published: 01 October 2017 in Energy Procedia
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ACS Style

Renan Moreno; Manuela Correia; Florinda Martins. Energy and environmental performance of wastewater treatment plants: A statistical approach. Energy Procedia 2017, 136, 296 -301.

AMA Style

Renan Moreno, Manuela Correia, Florinda Martins. Energy and environmental performance of wastewater treatment plants: A statistical approach. Energy Procedia. 2017; 136 ():296-301.

Chicago/Turabian Style

Renan Moreno; Manuela Correia; Florinda Martins. 2017. "Energy and environmental performance of wastewater treatment plants: A statistical approach." Energy Procedia 136, no. : 296-301.

Conference paper
Published: 18 September 2017 in IOP Conference Series: Materials Science and Engineering
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The Portuguese coast presents a large amount of potentially edible seaweeds that are underexploited. The identification of different macroalgae species and their availability in the northern and central coast of the continental territory was assessed. The nutritional value of seaweeds is discussed based on a literature review (when available) focused on data for species collected in Portugal with the aim to define the most important nutritional parameters that should be characterized in the samples. Possible health concerns related with the presence of contaminants are also considered.

ACS Style

C. Soares; S. Machado; E.F. Vieira; S. Morais; M.T. Teles; M. Correia; A. Carvalho; V. F. Domingues; M.J. Ramalhosa; C. Delerue-Matos; F. Antunes. Seaweeds from the Portuguese coast: A potential food resource? IOP Conference Series: Materials Science and Engineering 2017, 231, 012126 .

AMA Style

C. Soares, S. Machado, E.F. Vieira, S. Morais, M.T. Teles, M. Correia, A. Carvalho, V. F. Domingues, M.J. Ramalhosa, C. Delerue-Matos, F. Antunes. Seaweeds from the Portuguese coast: A potential food resource? IOP Conference Series: Materials Science and Engineering. 2017; 231 (1):012126.

Chicago/Turabian Style

C. Soares; S. Machado; E.F. Vieira; S. Morais; M.T. Teles; M. Correia; A. Carvalho; V. F. Domingues; M.J. Ramalhosa; C. Delerue-Matos; F. Antunes. 2017. "Seaweeds from the Portuguese coast: A potential food resource?" IOP Conference Series: Materials Science and Engineering 231, no. 1: 012126.

Research article
Published: 19 July 2017 in Journal of Chemical Education
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This paper reports a laboratorial internship included in the Portuguese Science and Technology promotion program “Internships for Young People in Laboratories (Ciência Viva no Laboratório)”, which provided high school students an opportunity to approach the reality of scientific and technological research in a higher education institution. During this internship, students acquired knowledge related to the assessment of the total antioxidant capacity (TAC) of fruits and their byproducts while learning techniques, such as molecular spectrophotometry, as an analytical methodology to measure TAC using the ferric reducing antioxidant power (FRAP) and the total phenolic content (TPC) assays. First, the students were introduced to solid–liquid extraction as a conventional technique to extract antioxidants from the selected matrices. In order to optimize the extraction yield, different solvents, temperatures, and extraction times were used. Then, the students developed skills on TPC and FRAP assays by performing calibration curves using standard antioxidants, namely, gallic acid and ascorbic acid, prior to the measurement of the TAC of fruits (apple and orange) and respective byproducts. Final analysis included TAC values for comparison between fruits and their byproducts and also the influence of the extraction conditions on the TAC levels. At the end, the students presented their findings in a scientific poster and in a postlaboratory quiz. This laboratorial internship has been carried out since 2012 and was designed to be performed during a week, 7 h per day, in groups of two young students.

ACS Style

Cristina Soares; Manuela Correia; Cristina Delerue-Matos; M. Fátima Barroso. Investigating the Antioxidant Capacity of Fruits and Fruit Byproducts through an Introductory Food Chemistry Experiment for High School. Journal of Chemical Education 2017, 94, 1291 -1295.

AMA Style

Cristina Soares, Manuela Correia, Cristina Delerue-Matos, M. Fátima Barroso. Investigating the Antioxidant Capacity of Fruits and Fruit Byproducts through an Introductory Food Chemistry Experiment for High School. Journal of Chemical Education. 2017; 94 (9):1291-1295.

Chicago/Turabian Style

Cristina Soares; Manuela Correia; Cristina Delerue-Matos; M. Fátima Barroso. 2017. "Investigating the Antioxidant Capacity of Fruits and Fruit Byproducts through an Introductory Food Chemistry Experiment for High School." Journal of Chemical Education 94, no. 9: 1291-1295.

Journal article
Published: 01 March 2017 in European Journal of Pharmaceutical Sciences
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A method based on the Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) was successfully developed and validated for the analysis of 26 pharmaceutical compounds belonging to different therapeutic classes (anorexics, stimulants, anxiolytics, antidepressants and laxatives), which are all prone to be illegally added into weight-loss plant food supplements (PFS) for their pharmacological activity. Internal standard calibration with six isotopically labelled compounds rendered good linearity in the range of 5 to 1000μg/l, depending on the compound, and good sensitivity with limits of quantification in the range of 0.02-9.80μg/l. Recoveries were assessed for all the 16 samples analysed and were found between 70% and 120% for over 90% of the analytes. The average recovery value was 90.8%, for the different studied matrices (liquids, liquid ampoules, tablets and capsules), with RSD values lower than 10% for all forms. The changes introduced to the QuEChERS procedure maintained the good performance characteristics of the extraction method while preserving the chromatographic system for the introduction of unwanted matrix compounds. Synephrine was the only compound detected and quantified in one sample, but at a very low concentration (768μg/l) and its presence may be due to the plant extracts used in the formulation, as synephrine is known to be a natural constituent of Citrus aurantium amara. Despite none of the 16 evaluated samples were found to be adulterated by the illegal addition of the drugs included in this work, the developed methodology can be very useful for monitoring the adulteration of weight-loss PFS.

ACS Style

Paula Paíga; Manuela J.E. Rodrigues; Manuela Correia; Joana S. Amaral; M. Beatriz P.P. Oliveira; Cristina Delerue-Matos. Analysis of pharmaceutical adulterants in plant food supplements by UHPLC-MS/MS. European Journal of Pharmaceutical Sciences 2017, 99, 219 -227.

AMA Style

Paula Paíga, Manuela J.E. Rodrigues, Manuela Correia, Joana S. Amaral, M. Beatriz P.P. Oliveira, Cristina Delerue-Matos. Analysis of pharmaceutical adulterants in plant food supplements by UHPLC-MS/MS. European Journal of Pharmaceutical Sciences. 2017; 99 ():219-227.

Chicago/Turabian Style

Paula Paíga; Manuela J.E. Rodrigues; Manuela Correia; Joana S. Amaral; M. Beatriz P.P. Oliveira; Cristina Delerue-Matos. 2017. "Analysis of pharmaceutical adulterants in plant food supplements by UHPLC-MS/MS." European Journal of Pharmaceutical Sciences 99, no. : 219-227.

Research article
Published: 23 January 2017 in Phytotherapy Research
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Pilocarpus microphyllus Stapf ex Wardlew (Rutaceae), popularly known as jaborandi, is a plant native to the northern and northeastern macroregions of Brazil. Several alkaloids from this species have been isolated. There are few reports of antibacterial and anthelmintic activities for these compounds. In this work, we report the antibacterial and anthelmintic activity of five alkaloids found in P. microphyllus leaves, namely, pilosine, epiisopilosine, isopilosine, epiisopiloturine and macaubine. Of these, only anthelmintic activity of one of the compounds has been previously reported. Nuclear magnetic resonance, HPLC and mass spectrometry were combined and used to identify and confirm the structure of the five compounds. As regards the anthelmintic activity, the alkaloids were studied using in vitro assays to evaluate survival time and damaged teguments for Schistosoma mansoni adult worms. We found epiisopilosine to have anthelmintic activity at very low concentrations (3.125 μg mL−1); at this concentration, it prevented mating, oviposition, reducing motor activity and altered the tegument of these worms. In contrast, none of the alkaloids showed antibacterial activity. Additionally, alkaloids displayed no cytotoxic effect on vero cells. The potent anthelmintic activity of epiisopilosine indicates the potential of this natural compound as an antiparasitic agent. Copyright © 2017 John Wiley & Sons, Ltd.

ACS Style

Jefferson A. Rocha; Ivanilza M. Andrade; Leiz M.C. Véras; Patrick Veras Quelemes; David F. Lima; Maria J.S. Soares; Pedro L.S. Pinto; Simon J. Mayo; Galya Ivanova; Maria Rangel; Manuela Correia; Ana Carolina Mafud; Yvonne Mascarenhas; Cristina Delerue-Matos; Josué de Moraes; Peter Eaton; José R.S.A. Leite. Anthelmintic, Antibacterial and Cytotoxicity Activity of Imidazole Alkaloids fromPilocarpus microphyllusLeaves. Phytotherapy Research 2017, 31, 624 -630.

AMA Style

Jefferson A. Rocha, Ivanilza M. Andrade, Leiz M.C. Véras, Patrick Veras Quelemes, David F. Lima, Maria J.S. Soares, Pedro L.S. Pinto, Simon J. Mayo, Galya Ivanova, Maria Rangel, Manuela Correia, Ana Carolina Mafud, Yvonne Mascarenhas, Cristina Delerue-Matos, Josué de Moraes, Peter Eaton, José R.S.A. Leite. Anthelmintic, Antibacterial and Cytotoxicity Activity of Imidazole Alkaloids fromPilocarpus microphyllusLeaves. Phytotherapy Research. 2017; 31 (4):624-630.

Chicago/Turabian Style

Jefferson A. Rocha; Ivanilza M. Andrade; Leiz M.C. Véras; Patrick Veras Quelemes; David F. Lima; Maria J.S. Soares; Pedro L.S. Pinto; Simon J. Mayo; Galya Ivanova; Maria Rangel; Manuela Correia; Ana Carolina Mafud; Yvonne Mascarenhas; Cristina Delerue-Matos; Josué de Moraes; Peter Eaton; José R.S.A. Leite. 2017. "Anthelmintic, Antibacterial and Cytotoxicity Activity of Imidazole Alkaloids fromPilocarpus microphyllusLeaves." Phytotherapy Research 31, no. 4: 624-630.

Journal article
Published: 15 April 2016 in Food Analytical Methods
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Pesticides are among the most investigated priority pollutants in agricultural products due to their widespread use and toxicity. The olive fruit fly (Bactrocera oleae) is one of the main pests of the olive tree in Portugal, and for an effective protection against this plague, farmers rely mostly on the use of insecticides. Six olive samples were collected in four olive groves to evaluate the presence of residues of dimethoate used for the combat of olive fruit fly, in table olives at the time of harvest and after brine. QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) extraction was optimized, one factor at a time, applied to the olive samples, and the extracts were analysed using liquid chromatography–diode array detection. Positive results were obtained in two samples at the time of harvest (3.58 and 4.34 mg/kg fw). One olive grove was selected to test two concentrations of salt and assess their influence on the quantity of residues. After brine, dimethoate residues were not detected.

ACS Style

Paula Paíga; Carla Meneses; David H. Lopes; Manuela Correia; Cristina Delerue-Matos. Assessment of Dimethoate Residues in Olives at the Time of Harvest and After Brine Using QuEChERS Extraction. Food Analytical Methods 2016, 9, 3170 -3178.

AMA Style

Paula Paíga, Carla Meneses, David H. Lopes, Manuela Correia, Cristina Delerue-Matos. Assessment of Dimethoate Residues in Olives at the Time of Harvest and After Brine Using QuEChERS Extraction. Food Analytical Methods. 2016; 9 (11):3170-3178.

Chicago/Turabian Style

Paula Paíga; Carla Meneses; David H. Lopes; Manuela Correia; Cristina Delerue-Matos. 2016. "Assessment of Dimethoate Residues in Olives at the Time of Harvest and After Brine Using QuEChERS Extraction." Food Analytical Methods 9, no. 11: 3170-3178.

Book chapter
Published: 01 January 2016 in Encyclopedia of Food and Health
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ACS Style

M. Correia; M. Rodrigues; P. Paíga; C. Delerue-Matos. Fungicides. Encyclopedia of Food and Health 2016, 169 -176.

AMA Style

M. Correia, M. Rodrigues, P. Paíga, C. Delerue-Matos. Fungicides. Encyclopedia of Food and Health. 2016; ():169-176.

Chicago/Turabian Style

M. Correia; M. Rodrigues; P. Paíga; C. Delerue-Matos. 2016. "Fungicides." Encyclopedia of Food and Health , no. : 169-176.

Journal article
Published: 01 March 2015 in Science of The Total Environment
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The occurrence of seven pharmaceuticals and two metabolites belonging to non-steroidal anti-inflammatory drugs and analgesics therapeutic classes was studied in seawaters. A total of 101 samples covering fourteen beaches and five cities were evaluated in order to assess the spatial distribution of pharmaceuticals among north Portuguese coast. Seawaters were selected in order to embrace different bathing water quality (excellent, good and sufficient). Acetaminophen, ketoprofen and the metabolite hydroxyibuprofen were detected in all the seawater samples at maximum concentrations of 584, 89.7 and 287 ng L− 1, respectively. Carboxyibuprofen had the highest seawater concentration (1227 ng L− 1). The temporal distribution of the selected pharmaceuticals during the bathing season showed that, in general, higher concentrations were detected in August and September. The environmental risk posed by the pharmaceuticals detected in seawaters towards different trophic levels (fish, daphnids and algae) was also assessed. Only diclofenac showed hazard quotients above one for fish, representing a potential risk for aquatic organisms. These results were observed in seawaters classified as excellent bathing water. Additional data is needed in order to support the identification and prioritization of risks posed by pharmaceuticals in marine environment

ACS Style

Aleksandar Lolić; Paula Paíga; Lúcia H.M.L.M. Santos; Sandra Ramos; Manuela Correia; Cristina Delerue-Matos. Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk. Science of The Total Environment 2015, 508, 240 -250.

AMA Style

Aleksandar Lolić, Paula Paíga, Lúcia H.M.L.M. Santos, Sandra Ramos, Manuela Correia, Cristina Delerue-Matos. Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk. Science of The Total Environment. 2015; 508 ():240-250.

Chicago/Turabian Style

Aleksandar Lolić; Paula Paíga; Lúcia H.M.L.M. Santos; Sandra Ramos; Manuela Correia; Cristina Delerue-Matos. 2015. "Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk." Science of The Total Environment 508, no. : 240-250.

Validation study
Published: 01 March 2015 in Journal of Pharmaceutical and Biomedical Analysis
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An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (SPE–UHPLC–MS/MS). Extraction conditions were optimized taking into account parameters like sorbent material, sample volume and sample pH. Method detection limits (MDLs) ranging from 0.02 to 8.18 ng/L were obtained. This methodology was successfully applied to the determination of the selected pharmaceuticals in seawater samples of Atlantic Ocean in the Northern Portuguese coast. All the pharmaceuticals have been detected in the seawater samples, with pharmaceuticals like ibuprofen, acetaminophen, ketoprofen and the metabolite hydroxyibuprofen being the most frequently detected at concentrations that can reach some hundreds of ng/L

ACS Style

Paula Paíga; Aleksandar Lolić; Floris Hellebuyck; Lúcia Santos; Manuela Correia; Cristina Delerue-Matos. Development of a SPE–UHPLC–MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater. Journal of Pharmaceutical and Biomedical Analysis 2015, 106, 61 -70.

AMA Style

Paula Paíga, Aleksandar Lolić, Floris Hellebuyck, Lúcia Santos, Manuela Correia, Cristina Delerue-Matos. Development of a SPE–UHPLC–MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater. Journal of Pharmaceutical and Biomedical Analysis. 2015; 106 ():61-70.

Chicago/Turabian Style

Paula Paíga; Aleksandar Lolić; Floris Hellebuyck; Lúcia Santos; Manuela Correia; Cristina Delerue-Matos. 2015. "Development of a SPE–UHPLC–MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater." Journal of Pharmaceutical and Biomedical Analysis 106, no. : 61-70.

Journal article
Published: 01 January 2014 in Microchemical Journal
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Trihalomethanes (THMs) are widely referred and studied as disinfection by-products (DBPs). The THMs that are most commonly detected are chloroform (TCM), bromodichloromethane (BDCM), chlorodibromomethane (CDBM), and bromoform (TBM). Several studies regarding the determination of THMs in swimming pool water and air samples have been published. This paper reviews the most recent work in this field, with a special focus on water and air sampling, sample preparation and analytical determination methods. An experimental study has been developed in order to optimize the headspace solid-phasemicroextraction (HS-SPME) conditions of TCM, BDCM, CDBM and TBM from water samples using a 23 factorial design. An extraction temperature of 45 °C, for 25min, and a desorption time of 5 min were found to be the best conditions. Analysis was performed by gas chromatography with an electron capture detector (GC-ECD). The method was successfully applied to a set of 27 swimming pool water samples collected in the Oporto area (Portugal). TCM was the only THM detected with levels between 4.5 and 406.5 μg L−1. Four of the samples exceeded the guideline value for total THMs in swimming pool water (100 μgL−1) indicated by the Portuguese Health Authority

ACS Style

Raquel Maia; Manuela Correia; Isabel M. Brás Pereira; Vitorino M. Beleza. Optimization of HS-SPME analytical conditions using factorial design for trihalomethanes determination in swimming pool water samples. Microchemical Journal 2014, 112, 164 -171.

AMA Style

Raquel Maia, Manuela Correia, Isabel M. Brás Pereira, Vitorino M. Beleza. Optimization of HS-SPME analytical conditions using factorial design for trihalomethanes determination in swimming pool water samples. Microchemical Journal. 2014; 112 ():164-171.

Chicago/Turabian Style

Raquel Maia; Manuela Correia; Isabel M. Brás Pereira; Vitorino M. Beleza. 2014. "Optimization of HS-SPME analytical conditions using factorial design for trihalomethanes determination in swimming pool water samples." Microchemical Journal 112, no. : 164-171.

Validation study
Published: 03 January 2013 in Journal of Agricultural and Food Chemistry
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The present work describes the development of an analytical method for the determination of methiocarb and its degradation products (methiocarb sulfoxide and methiocarb sulfone) in banana samples, using the QuEChERS (quick, easy, cheap, effective, rugged, and safe) procedure followed by liquid chromatography coupled to photodiode array detector (LC-PAD). Calibration curves were linear in the range of 0.5–10 mg L–1 for all compounds studied. The average recoveries, measured at 0.1 mg kg–1 wet weight, were 92.0 (RSD = 1.8%, n = 3), 84.0 (RSD = 3.9%, n = 3), and 95.2% (RSD = 1.9%, n = 3) for methiocarb sulfoxide, methiocarb sulfone, and methiocarb, respectively. Banana samples treated with methiocarb were collected from an experimental field. The developed method was applied to the analysis of 24 samples (peel and pulp) and to 5 banana pulp samples. Generally, the highest levels were found for methiocarb sulfoxide and methiocarb. Methiocarb sulfone levels were below the limit of quantification, except in one sample (not detected).

ACS Style

Alexandra Plácido; Paula Paíga; David Horta Lopes; Manuela Correia; Cristina Delerue-Matos. Determination of Methiocarb and Its Degradation Products, Methiocarb Sulfoxide and Methiocarb Sulfone, in Bananas Using QuEChERS Extraction. Journal of Agricultural and Food Chemistry 2013, 61, 325 -331.

AMA Style

Alexandra Plácido, Paula Paíga, David Horta Lopes, Manuela Correia, Cristina Delerue-Matos. Determination of Methiocarb and Its Degradation Products, Methiocarb Sulfoxide and Methiocarb Sulfone, in Bananas Using QuEChERS Extraction. Journal of Agricultural and Food Chemistry. 2013; 61 (2):325-331.

Chicago/Turabian Style

Alexandra Plácido; Paula Paíga; David Horta Lopes; Manuela Correia; Cristina Delerue-Matos. 2013. "Determination of Methiocarb and Its Degradation Products, Methiocarb Sulfoxide and Methiocarb Sulfone, in Bananas Using QuEChERS Extraction." Journal of Agricultural and Food Chemistry 61, no. 2: 325-331.

Evaluation study
Published: 01 December 2012 in Food Chemistry
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A QuEChERS method for the extraction of ochratoxin A (OTA) from bread samples was evaluated. A factorial design (23) was used to find the optimal QuEChERS parameters (extraction time, extraction solvent volume and sample mass). Extracts were analysed by LC with fluorescence detection. The optimal extraction conditions were: 5 g of sample, 15 mL of acetonitrile and 3 min of agitation. The extraction procedure was validated by systematic recovery experiments at three levels. The recoveries obtained ranged from 94.8% (at 1.0 μg kg -1) to 96.6% (at 3.0 μg kg -1). The limit of quantification of the method was 0.05 μg kg -1. The optimised procedure was applied to 20 samples of different bread types (‘‘Carcaça’’, ‘‘Broa de Milho’’, and ‘‘Broa de Avintes’’) highly consumed in Portugal. None of the samples exceeded the established European legal limit of 3 μg kg -1

ACS Style

Paula Paíga; Simone Morais; Maria Teresa Oliva-Teles; Manuela Correia; Cristina Delerue-Matos; Sofia Duarte; Angelina Pena; Celeste Lino. Extraction of ochratoxin A in bread samples by the QuEChERS methodology. Food Chemistry 2012, 135, 2522 -2528.

AMA Style

Paula Paíga, Simone Morais, Maria Teresa Oliva-Teles, Manuela Correia, Cristina Delerue-Matos, Sofia Duarte, Angelina Pena, Celeste Lino. Extraction of ochratoxin A in bread samples by the QuEChERS methodology. Food Chemistry. 2012; 135 (4):2522-2528.

Chicago/Turabian Style

Paula Paíga; Simone Morais; Maria Teresa Oliva-Teles; Manuela Correia; Cristina Delerue-Matos; Sofia Duarte; Angelina Pena; Celeste Lino. 2012. "Extraction of ochratoxin A in bread samples by the QuEChERS methodology." Food Chemistry 135, no. 4: 2522-2528.