A. James Mixson

Dr. A. James Mixson

University of Maryland, Baltimore, Baltimore, Maryland, USA
orcid
Professor, Department of Pathology, University of Maryland S...

Biography

My name is Archibald James Mixson, and in 1974, I graduated from Vanderbilt University with a major in mathematics. I earned an M.D. in 1979 and then did an Internal Medicine residency at Emory University in Atlanta, Ga. After finishing a staff fellowship in NCI to study intermediary metabolism, I did an endocrinology fellowship with the NIDDK. I am board certified in Internal Medicine and Endocrinology. In 1986, I joined the pathology department at the University of Maryland School of Medicine and have been a full professor since 2013. My laboratory initially focused on the non-viral delivery of anti-angiogenic “nucleic acids” utilizing in vitro or in vivo models. Currently, research in my laboratory is directed at developing novel histidine-rich peptides as nucleic acid carriers and antifungal agents. Significant accomplishments in the nucleic acid delivery field in our laboratory include the first group to deliver a tumor suppressor gene (p53) intravenously and reduce tumor size, one of the earliest groups to demonstrate that anti-angiogenesis was an essential mechanism for the bystander effect of p53 gene therapy and the first group to deliver systemically genes encoding anti-angiogenic peptides. During the last two decades, our laboratory has developed histidine-rich peptides as carriers of nucleic acids. From these studies, I have been awarded several patents on gene therapy, anti-angiogenesis, and drug delivery carriers.

Affiliations

University of Maryland, Baltimore

Baltimore, Maryland, USA

Honors and Awards

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Experience

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