We solve the time-dependent Gross-Pitaevskii equation by a variational ansatz to calculate the excitation spectrum of a Bose-Einstein condensate in a trap. The trial wave function is a Gaussian which allows an essentially analytical treatment of the problem. Our results reproduce numerical calculations over the whole range from small to large particle numbers, and agree exactly with the Stringari results in the strong interaction limit. Excellent agreement is obtained with the recent JILA experiment and predictions for the negative scattering length case are also made.

We obtain analytic solutions to the Gross-Pitaevskii equation with negative scattering length in highly asymmetric traps. We find that in these traps the Bose-Einstein condensates behave like quasiparticles and do not expand when the trapping in one direction is eliminated. The results can be applicable to the control of the motion of Bose-Einstein condensates.

A variational technique is applied to solve the time-dependent nonlinear Schrödinger equation (Gross-Pitaevskii equation) with the goal to model the dynamics of dilute ultracold atom clouds in the Bose-Einstein condensed phase. We derive analytical predictions for the collapse, equilibrium widths, and evolution laws of the condensate parameters and find them to be in very good agreement with our numerical simulations of the nonlinear Schrödinger equation. It is found that not only the number of particles, but also both the initial width of the condensate and the effect of different perturbations to the condensate may play a crucial role in the collapse dynamics. The results are applicable when the shape of the condensate is sufficiently simple.

Using Lie group theory and canonical transformations, we construct explicit solutions of nonlinear Schrödinger equations with spatially inhomogeneous nonlinearities. We present the general theory, use it to show that localized nonlinearities can support bound states with an arbitrary number solitons, and discuss other applications of interest to the field of nonlinear matter waves.

Using similarity transformations we construct explicit nontrivial solutions of nonlinear Schrödinger equations with potentials and nonlinearities depending both on time and on the spatial coordinates. We present the general theory and use it to calculate explicitly nontrivial solutions such as periodic (breathers), resonant, or quasiperiodically oscillating solitons. Some implications to the field of matter waves are also discussed.

Glioblastoma is a rapidly evolving high-grade astrocytoma that is distinguished pathologically from lower grade gliomas by the presence of necrosis and microvascular hyperplasia. Necrotic areas are typically surrounded by hypercellular regions known as “pseudopalisades” originated by local tumor vessel occlusions that induce collective cellular migration events. This leads to the formation of waves of tumor cells actively migrating away from central hypoxia. We present a mathematical model that incorporates the interplay among two tumor cell phenotypes, a necrotic core and the oxygen distribution. Our simulations reveal the formation of a traveling wave of tumor cells that reproduces the observed histologic patterns of pseudopalisades. Additional simulations of the model equations show that preventing the collapse of tumor microvessels leads to slower glioma invasion, a fact that might be exploited for therapeutic purposes.