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Dr. Laura Papetti
Bambino Gesù Children Hospital, Rome

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0 Migraine
0 Multiple Sclerosis
0 Pain
0 headache
0 child neurology

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headache
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Journal article
Published: 14 August 2021 in Journal of Clinical Medicine
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There is a high comorbidity between migraine and sleep disorders (SD), with a mutual dependence between sleep and headache. This study aimed to analyze the relationship between headache features (migraine frequency and severity, migraine equivalents, use and efficacy of treatments) and sleep in pediatric migraine. Parents of children and adolescents with migraine completed the Children’s Sleep Habits Questionnaire (CSHQ) and the Epworth Sleepiness Scale for Children and Adolescents (ESS-CHAD) and answered questions about headache characteristics. The presence of SD was defined according to CSHQ score. SD were detected in 72.9% of 140 subjects, but only 5.0% already received a diagnosis. Patients with SD presented statistically significant higher headache frequency (p = 0.031) and higher prevalence of migraine equivalents (p = 0.007). A higher CSHQ total score was associated with higher frequency of severe attacks (p = 0.012) and lower acute drug efficacy (p = 0.003). Significant positive correlations of sleep onset delay, sleep duration and nightwakings subscales with migraine frequency emerged. Our findings indicate that SD are highly prevalent in pediatric migraine and frequently associated with a higher headache severity and lower response to acute therapy, but often remain underdiagnosed. Improving sleep quality could help to reduce migraine intensity and disability and vice versa.

ACS Style

Alessandra Voci; Oliviero Bruni; Michela Ada Noris Ferilli; Laura Papetti; SamuelA Tarantino; Fabiana Ursitti; Giorgia Sforza; Federico Vigevano; Luigi Mazzone; Massimiliano Valeriani; Romina Moavero. Sleep Disorders in Pediatric Migraine: A Questionnaire-Based Study. Journal of Clinical Medicine 2021, 10, 3575 .

AMA Style

Alessandra Voci, Oliviero Bruni, Michela Ada Noris Ferilli, Laura Papetti, SamuelA Tarantino, Fabiana Ursitti, Giorgia Sforza, Federico Vigevano, Luigi Mazzone, Massimiliano Valeriani, Romina Moavero. Sleep Disorders in Pediatric Migraine: A Questionnaire-Based Study. Journal of Clinical Medicine. 2021; 10 (16):3575.

Chicago/Turabian Style

Alessandra Voci; Oliviero Bruni; Michela Ada Noris Ferilli; Laura Papetti; SamuelA Tarantino; Fabiana Ursitti; Giorgia Sforza; Federico Vigevano; Luigi Mazzone; Massimiliano Valeriani; Romina Moavero. 2021. "Sleep Disorders in Pediatric Migraine: A Questionnaire-Based Study." Journal of Clinical Medicine 10, no. 16: 3575.

Review
Published: 06 August 2021 in Nutrients
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The link between migraine and nutrition can be explored from several points of view. Lifestyle and, in particular, aspects of nutrition can have a significant impact on the course of pediatric migraine. In addition, some dietary treatments, such as the ketogenic diet, and some active ingredients present in foods (nutraceuticals) may have a therapeutic effect on migraine. A diet that can control weight gain and obesity has beneficial effects on migraine severity. On the other hand, when we talk about the link between nutrition and headaches, it is also necessary to point out that some public information is actually fake news that has no scientific basis. The purpose of this review is to provide an update on the salient points linking pediatric migraine to nutritional principles, focusing on the relationship between weight and headaches, the therapeutic effect of food for medical purposes, the ketogenic diet as a migraine treatment, and the relationship between migraine and dietary habits.

ACS Style

Laura Papetti; Romina Moavero; Michela Ferilli; Giorgia Sforza; SamuelA Tarantino; Fabiana Ursitti; Claudia Ruscitto; Federico Vigevano; Massimiliano Valeriani. Truths and Myths in Pediatric Migraine and Nutrition. Nutrients 2021, 13, 2714 .

AMA Style

Laura Papetti, Romina Moavero, Michela Ferilli, Giorgia Sforza, SamuelA Tarantino, Fabiana Ursitti, Claudia Ruscitto, Federico Vigevano, Massimiliano Valeriani. Truths and Myths in Pediatric Migraine and Nutrition. Nutrients. 2021; 13 (8):2714.

Chicago/Turabian Style

Laura Papetti; Romina Moavero; Michela Ferilli; Giorgia Sforza; SamuelA Tarantino; Fabiana Ursitti; Claudia Ruscitto; Federico Vigevano; Massimiliano Valeriani. 2021. "Truths and Myths in Pediatric Migraine and Nutrition." Nutrients 13, no. 8: 2714.

Journal article
Published: 24 February 2021 in Diagnostics
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Introduction. Our aim was to investigate the clinical features of primary new daily persistent headache (NDPH) in a cohort of paediatric patients. Methods. We reviewed the data of patients with persistent daily headache, attending the Headache Centre of Bambino Gesù Children from the January 2009. The ICHD-III criteria were used for diagnosis. Statistical analysis was conducted to study possible correlations between NDPH and population features (age and sex), NDPH and headache qualitative features, and NDPH and response to pharmacological therapies. Results. We included 46 subjects with NDPH. The features of pain more closely resembled those of migraine than to those of tension-type headache (62 vs. 38%). The NDPH patients showed nausea and vomiting less frequently than migraine ones (28.6 vs. 48.2%, p < 0.01). A total of 75% of NDPH patients experienced an onset of the symptoms in the winter months (November to February) (p < 0.01). NDPH was less common in very young children under 10 years of age. Almost 58% of NDPH patients received pharmacological therapy and the most used drug was amitriptyline. A reduction of attacks by at least 50% in a month was detected in 30.6% of patients. Conclusions. NDPH can be very disabling and correlates with seasonal factors. Although long term pharmacological therapy is recommended, considering the long duration that this headache can have, there are no data supporting the treatment choice.

ACS Style

Laura Papetti; Giorgia Sforza; SamuelA Tarantino; Romina Moavero; Claudia Ruscitto; Fabiana Ursitti; Michela Ferilli; Federico Vigevano; Massimiliano Valeriani. Features and Management of New Daily Persistent Headache in Developmental-Age Patients. Diagnostics 2021, 11, 385 .

AMA Style

Laura Papetti, Giorgia Sforza, SamuelA Tarantino, Romina Moavero, Claudia Ruscitto, Fabiana Ursitti, Michela Ferilli, Federico Vigevano, Massimiliano Valeriani. Features and Management of New Daily Persistent Headache in Developmental-Age Patients. Diagnostics. 2021; 11 (3):385.

Chicago/Turabian Style

Laura Papetti; Giorgia Sforza; SamuelA Tarantino; Romina Moavero; Claudia Ruscitto; Fabiana Ursitti; Michela Ferilli; Federico Vigevano; Massimiliano Valeriani. 2021. "Features and Management of New Daily Persistent Headache in Developmental-Age Patients." Diagnostics 11, no. 3: 385.

Journal article
Published: 25 January 2021 in Italian Journal of Pediatrics
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Background Post-Infectious Neurological Syndromes (PINS) are heterogeneous neurological disorders with post or para-infectious onset. PINS diagnosis is complex, mainly related to the absence of any recognized guidelines and a univocal definition. Aim of the study To elaborate a diagnostic guide for PINS. Materials and methods We retrospectively analysed patients younger than 14 years old admitted to Bambino Gesù Children’s Hospital in Rome for PINS from December 2005 to March 2018. Scientific literature using PubMed as research platform was analysed: the key words “Post-Infectious Neurological Syndromes” were used. Results A polysymptomatic presentation occurred in a percentage of 88% of the children. Motor signs and visual disturbances the most observed symptoms/signs were the most detached, followed by fever, speech disturbances, sleepiness, headache and bradipsychism. Blood investigations are compatible with inflammation, as a prodromal illnesses was documented in most cases. Normal cerebral spinal fluid (CSF) characteristics has been found in the majority of the study population. Magnetic resonance imaging (MRI) was positive for demyelinating lesions. Antibiotics, acyclovir and steroids have been given as treatment. Discussion We suggest diagnostic criteria for diagnosis of PINS, considering the following parameters: neurological symptoms, timing of disease onset, blood and CSF laboratory tests, MRI imaging. Conclusions We propose criteria to guide clinician to diagnose PINS as definitive, probable or possible. Further studies are required to validate diagnostic criteria.

ACS Style

Elena Bozzola; Giulia Spina; Massimiliano Valeriani; Laura Papetti; Fabiana Ursitti; Rino Agostiniani; Cristina Mascolo; Margherita Ruggiero; Chiara Di Camillo; Anna Quondamcarlo; Luigi Matera; Davide Vecchio; Luigi Memo; Alberto Villani. Management of pediatric post-infectious neurological syndromes. Italian Journal of Pediatrics 2021, 47, 1 -12.

AMA Style

Elena Bozzola, Giulia Spina, Massimiliano Valeriani, Laura Papetti, Fabiana Ursitti, Rino Agostiniani, Cristina Mascolo, Margherita Ruggiero, Chiara Di Camillo, Anna Quondamcarlo, Luigi Matera, Davide Vecchio, Luigi Memo, Alberto Villani. Management of pediatric post-infectious neurological syndromes. Italian Journal of Pediatrics. 2021; 47 (1):1-12.

Chicago/Turabian Style

Elena Bozzola; Giulia Spina; Massimiliano Valeriani; Laura Papetti; Fabiana Ursitti; Rino Agostiniani; Cristina Mascolo; Margherita Ruggiero; Chiara Di Camillo; Anna Quondamcarlo; Luigi Matera; Davide Vecchio; Luigi Memo; Alberto Villani. 2021. "Management of pediatric post-infectious neurological syndromes." Italian Journal of Pediatrics 47, no. 1: 1-12.

Review
Published: 26 July 2020 in International Journal of Molecular Sciences
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Neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorders (NMOSD) are a group of autoimmune inflammatory disorders of the central nervous system (CNS). Understanding of the molecular basis of these diseases in the last decades has led to an important improvement in the treatment of this disease, in particular, to the use of immunotherapeutic approaches, such as monoclonal antibodies and Hematopoietic Stem Cell Transplantation (HSCT). The aim of this review is to summarize the pathogenesis, biological basis and new treatment options of these disorders, with a particular focus on HSCT applications. Different HSCT strategies are being explored in NMOSD, both autologous and allogeneic HSCT, with the new emergence of therapeutic effects such as an induction of tolerance to auto-antigens and graft versus autoimmunity effects that can be exploited to hopefully treat a disease that still has prognosis.

ACS Style

Giulia Ceglie; Laura Papetti; Massimiliano Valeriani; Pietro Merli. Hematopoietic Stem Cell Transplantation in Neuromyelitis Optica-Spectrum Disorders (NMO-SD): State-of-the-Art and Future Perspectives. International Journal of Molecular Sciences 2020, 21, 5304 .

AMA Style

Giulia Ceglie, Laura Papetti, Massimiliano Valeriani, Pietro Merli. Hematopoietic Stem Cell Transplantation in Neuromyelitis Optica-Spectrum Disorders (NMO-SD): State-of-the-Art and Future Perspectives. International Journal of Molecular Sciences. 2020; 21 (15):5304.

Chicago/Turabian Style

Giulia Ceglie; Laura Papetti; Massimiliano Valeriani; Pietro Merli. 2020. "Hematopoietic Stem Cell Transplantation in Neuromyelitis Optica-Spectrum Disorders (NMO-SD): State-of-the-Art and Future Perspectives." International Journal of Molecular Sciences 21, no. 15: 5304.

Original research article
Published: 15 February 2019 in Frontiers in Neurology
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Introduction: Chronic headaches are not a rare condition in children and adolescents with negative effects on their quality of life. Our aims were to investigate the clinical features of chronic headache and usefulness of the International Classification of Headache Disorders 3rd edition (ICHD 3) criteria for the diagnosis in a cohort of pediatric patients. Methods: We retrospectively reviewed the charts of patients attending the Headache Center of Bambino Gesù Children and Insubria University Hospital during the 2010–2016 time interval. Statistical analysis was conducted to study possible correlations between: (a) chronic primary headache (CPH) and demographic data (age and sex), (b) CPH and headache qualitative features, (c) CPH and risk of medication overuse headache (MOH), and (d) CPH and response to prophylactic therapies. Moreover, we compared the diagnosis obtained by ICHD 3 vs. ICHD 2 criteria Results: We included 377 patients with CPH (66.4% females, 33.6% males, under 18 years of age). CPH was less frequent under 6 years of age (0.8%; p < 0.05) and there was no correlation between age/sex and different CPH types. The risk to develop MOH was higher after 15 years of age (p < 0.05). When we compared the diagnosis obtained by ICHD 2 and ICHD 3 criteria we found a significant difference for the undefined diagnosis (2.6% vs. 7.9%; p < 0.05), while the diagnosis of probable chronic migraine was only possible by using the ICHD2 criteria (11.9% of patients; p < 0.05). The main criterion which was not satisfied for a definitive diagnosis was the duration of the attacks less than 2 h (70% of patients younger than 6 years; p < 0.005). Amitriptyline and topiramate were the most effective drugs (p < 0.05), although no significant difference was found between them (p > 0.05). Conclusion: The ICHD 3 criteria show limitations when applied to children under 6 years of age. The risk of developing MOH increases with age. Although our “real word” study shows that amitriptyline and topiramate are the most effective drugs regardless of the CPH type, the lack of placebo-controlled data and the limited follow-up results did not allow us to conclude about the drug efficacy.

ACS Style

Laura Papetti; Irene Salfa; Barbara Battan; Romina Moavero; Cristiano Termine; Beatrice Bartoli; Francesca Di Nunzio; SamuelA Tarantino; Pierfrancesco Alaimo Di Loro; Federico Vigevano; Massimiliano Valeriani. Features of Primary Chronic Headache in Children and Adolescents and Validity of Ichd 3 Criteria. Frontiers in Neurology 2019, 10, 92 .

AMA Style

Laura Papetti, Irene Salfa, Barbara Battan, Romina Moavero, Cristiano Termine, Beatrice Bartoli, Francesca Di Nunzio, SamuelA Tarantino, Pierfrancesco Alaimo Di Loro, Federico Vigevano, Massimiliano Valeriani. Features of Primary Chronic Headache in Children and Adolescents and Validity of Ichd 3 Criteria. Frontiers in Neurology. 2019; 10 ():92.

Chicago/Turabian Style

Laura Papetti; Irene Salfa; Barbara Battan; Romina Moavero; Cristiano Termine; Beatrice Bartoli; Francesca Di Nunzio; SamuelA Tarantino; Pierfrancesco Alaimo Di Loro; Federico Vigevano; Massimiliano Valeriani. 2019. "Features of Primary Chronic Headache in Children and Adolescents and Validity of Ichd 3 Criteria." Frontiers in Neurology 10, no. : 92.

Review article
Published: 11 January 2018 in Journal of Pediatric Infectious Diseases
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Autoimmune encephalitis (AIE) can produce a very wide range of neuropsychiatric symptoms. A major challenge in diagnosis is that different symptoms may appear at different times and different levels of intensity, so the disease may mimic many other disorders. Pathogenesis is likely to be mediated by antibodies (Abs) to CNS proteins. This article focuses on recent clinical advances, newly characterized Abs, and treatment approaches to these disorders.

ACS Style

Irene Salfa; Federico Vigevano; Massimiliano Valeriani; Laura Papetti. Autoimmune Encephalitis in Children. Journal of Pediatric Infectious Diseases 2018, 14, 006 -010.

AMA Style

Irene Salfa, Federico Vigevano, Massimiliano Valeriani, Laura Papetti. Autoimmune Encephalitis in Children. Journal of Pediatric Infectious Diseases. 2018; 14 (1):006-010.

Chicago/Turabian Style

Irene Salfa; Federico Vigevano; Massimiliano Valeriani; Laura Papetti. 2018. "Autoimmune Encephalitis in Children." Journal of Pediatric Infectious Diseases 14, no. 1: 006-010.

Case reports
Published: 02 December 2017 in Headache: The Journal of Head and Face Pain
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Transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL) is benign and self-limited, with neurologic deficits including sensory disturbance of one body side, aphasia, nausea/vomiting, weakness, decreased vision, homonymous hemianopsia, photophobia. Acute confusional state can rarely occur. Papilledema and intracranial hypertension have also been described. It is a rare entity mainly affecting adults; however, it has been sporadically described in children and adolescents. In this clinical observational study, we describe a clinical series of three consecutive pediatric patients being diagnosed with HaNDL after presenting with altered consciousness, papilledema, and increased intracranial pressure. They all recovered without relapses. Presentation during childhood and adolescence is rare; the majority of pediatric cases presented with altered consciousness, which is infrequent in HaNDL. This may suggest that in childhood this symptom might be more common than in adults. All three patients presented with increased intracranial pressure and papilledema, thus suggesting that these aspects should be investigated in all patients presenting with this clinical pattern. Finally, all our patients began to suffer from migraine. This feature, together with the benign course of the disease, could favor the hypothesis of a migrainous pathophysiology of this syndrome, although this remains a speculative.

ACS Style

Romina Moavero; Laura Papetti; SamuelA Tarantino; Barbara Battan; Irene Salfa; Annalisa Deodati; Riccardo Schiaffini; Federico Vigevano; Massimiliano Valeriani. Syndrome of Transient Headache and Neurologic Deficits With Cerebrospinal Fluid Lymphocitosis Should Be Considered in Children Presenting With Acute Confusional State. Headache: The Journal of Head and Face Pain 2017, 58, 438 -442.

AMA Style

Romina Moavero, Laura Papetti, SamuelA Tarantino, Barbara Battan, Irene Salfa, Annalisa Deodati, Riccardo Schiaffini, Federico Vigevano, Massimiliano Valeriani. Syndrome of Transient Headache and Neurologic Deficits With Cerebrospinal Fluid Lymphocitosis Should Be Considered in Children Presenting With Acute Confusional State. Headache: The Journal of Head and Face Pain. 2017; 58 (3):438-442.

Chicago/Turabian Style

Romina Moavero; Laura Papetti; SamuelA Tarantino; Barbara Battan; Irene Salfa; Annalisa Deodati; Riccardo Schiaffini; Federico Vigevano; Massimiliano Valeriani. 2017. "Syndrome of Transient Headache and Neurologic Deficits With Cerebrospinal Fluid Lymphocitosis Should Be Considered in Children Presenting With Acute Confusional State." Headache: The Journal of Head and Face Pain 58, no. 3: 438-442.

Journal article
Published: 01 June 2017 in European Journal of Paediatric Neurology
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ACS Style

Margherita Nosadini; Tiziana Granata; Giulia Vigo; Elena Maria Giovanna Freri; Sara Matricardi; Federico Vigevano; Massimiliano Valeriani; Laura Papetti; Lucia Fusco; Maria Margherita Mancardi; Gaetano Cantalupo; Roberta Solazzi; Raffaele Falsaperla; Elisabetta Cesaroni; Dario Pruna; Gianni Cossu; Marta Melis; Clementina Boniver; Irene Toldo; Agnese Suppiej; Stefano Sartori. Preliminary follow-up data of an Italian multicenter cohort of paediatric anti-N-methyl-D-aspartate receptor encephalitis. European Journal of Paediatric Neurology 2017, 21, e122 .

AMA Style

Margherita Nosadini, Tiziana Granata, Giulia Vigo, Elena Maria Giovanna Freri, Sara Matricardi, Federico Vigevano, Massimiliano Valeriani, Laura Papetti, Lucia Fusco, Maria Margherita Mancardi, Gaetano Cantalupo, Roberta Solazzi, Raffaele Falsaperla, Elisabetta Cesaroni, Dario Pruna, Gianni Cossu, Marta Melis, Clementina Boniver, Irene Toldo, Agnese Suppiej, Stefano Sartori. Preliminary follow-up data of an Italian multicenter cohort of paediatric anti-N-methyl-D-aspartate receptor encephalitis. European Journal of Paediatric Neurology. 2017; 21 ():e122.

Chicago/Turabian Style

Margherita Nosadini; Tiziana Granata; Giulia Vigo; Elena Maria Giovanna Freri; Sara Matricardi; Federico Vigevano; Massimiliano Valeriani; Laura Papetti; Lucia Fusco; Maria Margherita Mancardi; Gaetano Cantalupo; Roberta Solazzi; Raffaele Falsaperla; Elisabetta Cesaroni; Dario Pruna; Gianni Cossu; Marta Melis; Clementina Boniver; Irene Toldo; Agnese Suppiej; Stefano Sartori. 2017. "Preliminary follow-up data of an Italian multicenter cohort of paediatric anti-N-methyl-D-aspartate receptor encephalitis." European Journal of Paediatric Neurology 21, no. : e122.

Research article
Published: 18 July 2016 in Cephalalgia
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Background Criteria defined by the International headache Society are commonly used for the diagnosis of the different headache types in both adults and children. However, some authors have stressed some limits of these criteria when applied to preschool age. Objective Our study aimed to describe the characteristics of primary headaches in children younger than 6 years and investigate how often the International Classification of Headache Disorders (ICHD) criteria allow a definitive diagnosis. Methods This retrospective study analysed the clinical feature of 368 children younger than 6 years with primary headache. Results We found that in our patients the percentage of undefined diagnosis was high when either the ICHD-II or the ICHD-III criteria were used. More than 70% of our children showed a duration of their attacks shorter than 1 hour. The absence of photophobia/phonophobia and nausea/vomiting significantly correlate with tension-type headache (TTH) and probable TTH. The number of first-degree relatives with migraine was positively correlated to the diagnosis of migraine in the patients ( p < 0.001). Conclusions Our study showed that the ICHD-III criteria are difficult to use in children younger than 6 years. The problem is not solved by the reduction of the lowest duration limit for the diagnosis of migraine to 1 hour, as was done in the ICHD-II.

ACS Style

Roberto Torriero; Alessandro Capuano; Rosanna Mariani; Roberto Frusciante; SamuelA Tarantino; Laura Papetti; Federico Vigevano; Massimiliano Valeriani. Diagnosis of primary headache in children younger than 6 years: A clinical challenge. Cephalalgia 2016, 37, 947 -954.

AMA Style

Roberto Torriero, Alessandro Capuano, Rosanna Mariani, Roberto Frusciante, SamuelA Tarantino, Laura Papetti, Federico Vigevano, Massimiliano Valeriani. Diagnosis of primary headache in children younger than 6 years: A clinical challenge. Cephalalgia. 2016; 37 (10):947-954.

Chicago/Turabian Style

Roberto Torriero; Alessandro Capuano; Rosanna Mariani; Roberto Frusciante; SamuelA Tarantino; Laura Papetti; Federico Vigevano; Massimiliano Valeriani. 2016. "Diagnosis of primary headache in children younger than 6 years: A clinical challenge." Cephalalgia 37, no. 10: 947-954.