The research focuses on identifying and utilizing bioactive substances from the rich biodiversity of the Jeju region to develop a disease control model. This approach aims to discover natural inhibitors of specific arthritis-inducing genes, including HIF2a, ZIP8, ERRg, and ZFP36L1. By exploring the inhibition mechanisms of these targets, the research could lead to innovative drug development for arthritis treatment. The investigation into ZIP8 as an iron and zinc transporter with implications in arthritis, and the potential of substances like umbelliferone and scopoletin targeting tyrosine kinases in anti-rheumatic therapy, aligns with the project's goals. Additionally, the use of disease-modifying antirheumatic drugs (DMARDs) and the exploration of drug repositioning for rheumatoid arthritis (RA) further supports the relevance of targeting these genes and pathways.