Heart valve fluid–structure interaction (FSI) analysis is one of the computationally challenging cases in cardiovascular fluid mechanics. The challenges include unsteady flow through a complex geometry, solid surfaces with large motion, and contact between the valve leaflets. We introduce here an isogeometric sequentially-coupled FSI (SCFSI) method that can address the challenges with an outcome of high-fidelity flow solutions. The SCFSI analysis enables dealing with the fluid and structure parts individually at different steps of the solutions sequence, and also enables using different methods or different mesh resolution levels at different steps. In the isogeometric SCFSI analysis here, the first step is a previously computed (fully) coupled Immersogeometric Analysis FSI of the heart valve with a reasonable flow solution. With the valve leaflet and arterial surface motion coming from that, we perform a new, higher-fidelity fluid mechanics computation with the space–time topology change method and isogeometric discretization. Both the immersogeometric and space–time methods are variational multiscale methods. The computation presented for a bioprosthetic heart valve demonstrates the power of the method introduced.

A recently introduced NURBS mesh generation method for complex-geometry Isogeometric Analysis (IGA) is applied to building a high-quality mesh for a gas turbine. The compressible flow in the turbine is computed using the IGA and a stabilized method with improved discontinuity-capturing, weakly-enforced no-slip boundary-condition, and sliding-interface operators. The IGA results are compared with the results from the stabilized finite element simulation to reveal superior performance of the NURBS-based approach. Free-vibration analysis of the turbine rotor using the structural mechanics NURBS mesh is also carried out and shows that the NURBS mesh generation method can be used also in structural mechanics analysis. With the flow field from the NURBS-based turbine flow simulation, the Courant number is computed based on the NURBS mesh local length scale in the flow direction to show some of the other positive features of the mesh generation framework. The work presented further advances the IGA as a fully-integrated and robust design-to-analysis framework, and the IGA-based complex-geometry flow computation with moving boundaries and interfaces represents the first of its kind for compressible flows.