Ryan Moseley

Prof. Ryan Moseley

Dentistry, Cardiff University, Cardiff, UK
orcid

Research Focus & Metrics

Academic Career Length

30Years (1997-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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23 July 2021 in Biomolecules
Verified
Journal Article
Open access
PDF file
YTYifan Tai
Yifan Tai
EWEmma L. Woods
Emma L. Woods
JDJordanna Dally
Jordanna Dally
KDKong Deling
Kong Deling
Robert SteadmanRobert Steadman
Robert Steadman
Adam C MidgleyAdam C Midgley
Adam C Midgley
Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in pathophysiological processes. Myofibroblasts mediate wound contractions, but their persistent presence in tissues is central to driving fibrosis, making them attractive cell targets for the development of therapeutic treatments. However, due to shared cellular markers with several other phenotypes, the specific targeting of myofibroblasts has long presented a scientific and clinical challenge. In recent years, myofibroblasts have drawn much attention among scientific research communities from multiple disciplines and specialisations. As further research uncovers the characterisations of myofibroblast formation, function, and regulation, the realisation of novel interventional routes for myofibroblasts within pathologies has emerged. The research community is approaching the means to finally target these cells, to prevent fibrosis, accelerate scarless wound healing, and attenuate associated disease-processes in clinical settings. This comprehensive review article describes the myofibroblast cell phenotype, their origins, and their diverse physiological and pathological functionality. Special attention has been given to mechanisms and molecular pathways governing myofibroblast differentiation, and updates in molecular interventions.

1 December 1997 in Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Verified
Journal Article
Closed access
Ryan MoseleyRyan Moseley
Ryan Moseley
RWR.J Waddington
R.J Waddington
GEG Embery
G Embery

1 March 2004 in British Journal of Dermatology
Verified
Journal Article
Closed access
PDF file
Ryan MoseleyRyan Moseley
Ryan Moseley
JSJ.E. Stewart
J.E. Stewart
PSP. Stephens
P. Stephens
RWR.J. Waddington
R.J. Waddington
DTDave Thomas
Dave Thomas

19 July 2004 in Wound Repair and Regeneration
Verified
Journal Article
Closed access
PDF file
Ryan MoseleyRyan Moseley
Ryan Moseley
JHJoanna R. Hilton
Joanna R. Hilton
RWRachel J. Waddington
Rachel J. Waddington
KHKeith G. Harding
Keith G. Harding
PSPhil Stephens
Phil Stephens
DTDave Thomas
Dave Thomas

1 September 2008 in Journal of Controlled Release
Verified
Journal Article
Closed access
JHJoseph Hardwicke
Joseph Hardwicke
EFElaine Lesley Ferguson
Elaine Lesley Ferguson
Ryan MoseleyRyan Moseley
Ryan Moseley
PSPhil Stephens
Phil Stephens
DTDave Thomas
Dave Thomas
RDRuth Duncan
Ruth Duncan