Patrick J. Guiry

Prof. Patrick J. Guiry


Research Focus & Metrics

Academic Career Length

37Years (1990-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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19 March 2021 in Chemical Reviews
Verified
Journal Article
Open access
OPOscar Pàmies
Oscar Pàmies
JMJèssica Margalef
Jèssica Margalef
SCSantiago Cañellas
Santiago Cañellas
JJJinju James
Jinju James
EJEric Judge
Eric Judge
MDMontserrat Diéguez
Montserrat Diéguez
This Review compiles the evolution, mechanistic understanding, and more recent advances in enantioselective Pd-catalyzed allylic substitution and decarboxylative and oxidative allylic substitutions. For each reaction, the catalytic data, as well as examples of their application to the synthesis of more complex molecules, are collected. Sections in which we discuss key mechanistic aspects for high selectivity and a comparison with other metals (with advantages and disadvantages) are also included. For Pd-catalyzed asymmetric allylic substitution, the catalytic data are grouped according to the type of nucleophile employed. Because of the prominent position of the use of stabilized carbon nucleophiles and heteronucleophiles, many chiral ligands have been developed. To better compare the results, they are presented grouped by ligand types. Pd-catalyzed asymmetric decarboxylative reactions are mainly promoted by PHOX or Trost ligands, which justifies organizing this section in chronological order. For asymmetric oxidative allylic substitution the results are grouped according to the type of nucleophile used.

15 June 2011 in Chemical Society Reviews
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DCDennis Mc Cartney
Dennis Mc Cartney
PGPatrick J. Guiry
Patrick J. Guiry
The asymmetric inter- and intramolecular Heck and related reactions are comprehensively reviewed, from their original development to recent advances in terms of substrate scope, reactivity, regio- and enantioselectivity. Their reaction mechanisms/catalytic cycles are discussed in order to understand the concepts underpinning the significant recent developments of these processes. The design and application of new chiral ligands has been pivotal to reaction enhancements and, for each Heck and related process, we classify ligands by the nature of the denticity, chirality and donor atoms involved. In this manner, the continued development of ligand architectural design and application can be more easily monitored for each process. Significant improvements in reaction times, a disadvantage in many Heck reactions, have been addressed through a combination the use of microwave-assisted protocols and ligand design. The asymmetric Fujiwara-Moritani and oxidative boron Heck-type reactions, recent additions to Heck type processes, will also be discussed in this critical review (149 references).

26 April 2004 in Advanced Synthesis & Catalysis
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Journal Article
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PGPatrick J. Guiry
Patrick J. Guiry
CSCormac P. Saunders
Cormac P. Saunders

21 November 2013 in Chemical Society Reviews
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Journal Article
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PDF file
MCMichael P. Carroll
Michael P. Carroll
PGPatrick J. Guiry
Patrick J. Guiry
P,N ligands are an important class of ligands for asymmetric catalysis. In this tutorial review an up to date account of recent applications of these ligands in asymmetric catalysis is presented. A special focus is given to newer classes of ligands and the application of more established P,N ligands in novel reactions.

8 April 2005 in Advanced Synthesis & Catalysis
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Journal Article
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ACAnne‐Marie Carroll
Anne‐Marie Carroll
TOTimothy P. O'Sullivan
Timothy P. O'Sullivan
PGPatrick J. Guiry
Patrick J. Guiry

5 November 2007 in Advanced Synthesis & Catalysis
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Journal Article
Closed access
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GHGráinne C. Hargaden
Gráinne C. Hargaden
PGPatrick J. Guiry
Patrick J. Guiry