Negation is known to have inhibitory consequences for the information under its scope. However, how it produces such effects remains poorly understood. Recently, it has been proposed that negation processing might be implemented at the neural level by the recruitment of inhibitory and cognitive control mechanisms. On this line, this manuscript offers the hypothesis that negation reuses general-domain mechanisms that subserve inhibition in other non-linguistic cognitive functions. The first two sections describe the inhibitory effects of negation on conceptual representations and its embodied effects, as well as the theoretical foundations for the reuse hypothesis. The next section describes the neurophysiological evidence that linguistic negation interacts with response inhibition, along with the suggestion that both functions share inhibitory mechanisms. Finally, the manuscript concludes that the functional relation between negation and inhibition observed at the mechanistic level could be easily integrated with predominant cognitive models of negation processing.

According to the literature, negations such as “not” or “don't” reduce the accessibility in memory of the concepts under their scope. Moreover, negations applied to action contents (e.g., “don't write the letter”) impede the activation of motor processes in the brain, inducing “disembodied” representations. These facts provide important information on the behavioral and neural consequences of negations. However, how negations themselves are processed in the brain is still poorly understood. In two electrophysiological experiments, we explored whether sentential negation shares neural mechanisms with action monitoring or inhibition. Human participants read action-related sentences in affirmative or negative form (“now you will cut the bread” vs “now you will not cut the bread”) while performing a simultaneous Go/NoGo task. The analysis of the EEG rhythms revealed that theta oscillations were significantly reduced for NoGo trials in the context of negative sentences compared with affirmative sentences. Given the fact that theta oscillations are often considered as neural markers of response inhibition processes, their modulation by negative sentences strongly suggests that negation uses neural resources of response inhibition. We propose a new approach that views the syntactic operator of negation as relying on the neural machinery of high-order action-monitoring processes.SIGNIFICANCE STATEMENTPrevious studies have shown that linguistic negation reduces the accessibility of the negated concepts and suppresses the activation of specific brain regions that operate in affirmative statements. Although these studies focus on the consequences of negation on cognitive and neural processes, the proper neural mechanisms of negation have not yet been explored. In the present EEG study, we tested the hypothesis that negation uses the neural network of action inhibition. Using a Go/NoGo task embedded in a sentence comprehension task, we found that negation in the context of NoGo trials modulates frontal theta rhythm, which is usually considered a signature of action inhibition and control mechanisms.