Dr. Ana Ćirić
Department of Plant Physiology, University of Belgrade, Institute for Biological Research "Siniša Stanković" - National Institute of the Republic of Serbia, Belgrade, Beograd, Serbia
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Academic Career Length
67Years (1960-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 January 2010 in Bioorganic & Medicinal Chemistry
Journal Article
KOKouatli Omar
Kouatli Omar
AGAthina Geronikaki
Athina Geronikaki
Panagiotis ZoumpoulakisCCCharalabos Camoutsis
Charalabos Camoutsis
MSMarina Soković
Marina Soković
Jasmina Glamočlija +1
1 February 2008 in Bioorganic & Medicinal Chemistry
Journal Article
IEIraj Rahavi Ezabadi
Iraj Rahavi Ezabadi
CCCharalabos Camoutsis
Charalabos Camoutsis
Panagiotis ZoumpoulakisAGAthina Geronikaki
Athina Geronikaki
MSMarina Soković
Marina Soković
Ana Ćirić +1
Journal Article
Despite abundant research in the field of antifungal drug discovery, fungal infections remain a significant healthcare burden. There is an emerging need for the development of novel antifungals since those currently available are limited and do not completely provide safe and secure protection. Since the current knowledge regarding the physiology of fungal cells and the infection mechanisms is greater than ever, we have the opportunity to use this for the development of novel generations of antifungals. In this review, we selected and summarized recent studies describing agents employing different antifungal mechanisms. These mechanisms include interference with fungal resistance, including impact on the efflux pumps and heat shock protein 90. Additionally, interference with virulence factors, such as biofilms and hyphae; the impact on fungal enzymes, metabolism, mitochondria, and cell wall; and antifungal vaccines are explored. The agents investigated belong to different classes of natural or synthetic molecules with significant attention given also to plant extracts. The efficacy of these antifungals has been studied mainly in vitro with some in vivo, and clinical studies are needed. Nevertheless, there is a large quantity of products employing novel antifungal mechanisms that can be further explored for the development of new generation of antifungals.
1 January 2018 in Industrial Crops and Products
Journal Article
Bruno MelgarMDMaria Inês Dias
Maria Inês Dias
Ana ĆirićMSMarina Soković
Marina Soković
Garcia-Castello Esperanza M.
Isabel Ferreira +2
1 August 2013 in Food and Chemical Toxicology
Journal Article
Sandrina A. HelenoIsabel FerreiraAEAna Paula Esteves
Ana Paula EstevesAna ĆirićJasmina GlamočlijaMQMaria-João Queiroz
Maria-João Queiroz +2
14 January 2014 in Natural Product Research
Journal Article
BPBoris PEJIN
Boris PEJIN
Aleksandar Radoje SavićMSMarina Soković
Marina SokovićJasmina GlamočlijaAna Ćirić
Milos Mojovic +2
The antiradical activity of phytol was evaluated by electron paramagnetic resonance towards hydroxyl radical (·OH), superoxide anion radical (·O2(-)), methoxy radical (·CH2OH), carbon-dioxide anion radical (·CO2(-)), as well as towards nitric-oxide radical (·NO) and 2,2-diphenyl-1-picrylhydrazyl (·DPPH) radical. It reduced the production of all tested radicals showing more promising activity against ·CO2(-), ·CH2OH and ·DPPH radicals (56%, 50% and 48%, respectively) in comparison with ·NO, ·O2(-) and ·OH radicals (38%, 23% and 15%, respectively). The antimicrobial activity of phytol was evaluated by the microdilution method against eight bacterial and eight fungal strains. To varying degrees, it was proven to be active against all tested bacteria and fungi (MIC 0.003-0.038 mg/mL and MBC 0.013-0.052 mg/mL, MIC 0.008-0.016 mg/mL and MFC 0.090-0.520 mg/mL, respectively). According to the obtained results, medical foods containing phytol may support development of new therapies for heart disease.
About Me
Dr. Ana Ćirić is a principal research fellow at the Institute for Biological Research “Siniša Stanković”, National Institute of Republic of Serbia. Her main research topics are the isolation of secondary metabolites from micromycetes and plants, the antimicrobial activity of biologically active compounds isolated and determined from plants, macromycetes, invertebrates and synthetic compounds, investigations of the influence of natural products on the findings of quorum sensing (QS) antagonists and biofilm formation by P. aeruginosa, and the interactions of plants and fungi and the development of new metabolic pathways of certain compounds in the biotransformation process. Her current projects are: 2018–2022 Horizon 2020. 2021–2023 Strategic projects of scientific and technological cooperation programs between the Rep. Serbia and the PR of China: “Development of new fermented products enriched with plant and mushroom extracts” and "Searching for novel sources of biologically active compounds: Study on river sponge Ephydatia fluviatilis from Serbia" as the project manager for the latter. She has studied at the University of Athens, Faculty of Pharmacy, Department of Pharmacognosy, in 2002, 2003 and 2005. Dr. Ćirić has published 276 papers in international peer reviewed journals of high importance, with over 3900 citations and with an h-index of 34. She has participated as a mentor or a committee member to 6 doctor's and 7 master's theses.