Having graduated from medical school at the University of Essen (Germany) and post-doctoral training in Essen and at the University of California at San Diego (US), my research focused on the integration of experimental and clinical pharmacology of the cardiovascular and urogenital system. Key positions include Chair of the Dept. of Pharmacology at the University of Amsterdam (Netherlands) and Global Head of Product and Pipeline Scientific Support at Boehringer Ingelheim. I currently work at the University of Mainz (Germany). My scientific work has resulted in >500 peer-reviewed publications cited >30,000 times. Current key projects include the following: - replicability of non-clinical data; - urinary bladder in diabetes; - clinical pharmacology of overactive bladder syndrome; - chances and limitations of non-interventional studies.