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Dr. Claudio Liguori
Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 100133
Rome, Italy
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Academic Career Length
15Years (2012-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 December 2014 in JAMA Neurology
Journal Article
CLClaudio Liguori
Claudio LiguoriARAndrea Romigi
Andrea RomigiMNMarzia Nuccetelli
Marzia Nuccetelli
SZSilvana Zannino
Silvana Zannino
GSGiuseppe Sancesario
Giuseppe Sancesario
FPFabio Placidi
Fabio Placidi
+9
Alzheimer disease (AD) is a neurodegenerative disorder predominantly characterized by progressive memory loss and gradual decline in global cognition.1 Alzheimer disease is often complicated by circadian rhythm disruption and sleep disturbances, including nightly awakenings and nonrapid eye movement (non-REM)/REM sleep dysregulation, which have a major effect on the quality of life of patients and their caregivers.2-5 Neuropathological characteristics of AD include the progressive accumulation of extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary tangles of tau proteins, which produce the dramatic loss of neurons and synapses and derange the brain’s functional and structural physiological processes. Brain regions and networks involved in the control of the sleep-wake rhythm have been also reported to be affected in AD.6 At present, Aβ1-42 and total (t-tau) and phosphorylated (p-tau) tau proteins are considered the established cerebrospinal fluid (CSF) biomarkers to support a diagnosis of AD.7-9
1 August 2020 in Brain, Behavior, and Immunity
Journal Article
CLClaudio Liguori
Claudio LiguoriMPMariangela Pierantozzi
Mariangela Pierantozzi
MSMatteo Spanetta
Matteo Spanetta
LSLoredana Sarmati
Loredana Sarmati
Novella CestaNMNicola Biagio Mercuri
Nicola Biagio Mercuri
+9
1 February 2021 in Sleep Medicine Reviews
Journal Article
CLClaudio Liguori
Claudio LiguoriMMMichelangelo Maestri
Michelangelo Maestri
MSMatteo Spanetta
Matteo Spanetta
FPFabio Placidi
Fabio Placidi
EBEnrica Bonanni
Enrica Bonanni
BGbiancamaria guarnieri
biancamaria guarnieri +1
1 April 2016 in Neurobiology of Aging
Journal Article
CLClaudio Liguori
Claudio LiguoriMNMarzia Nuccetelli
Marzia Nuccetelli
FIFrancesca Izzi
Francesca Izzi
GSGiuseppe Sancesario
Giuseppe Sancesario
ARAndrea Romigi
Andrea RomigiFPFabio Placidi
Fabio Placidi
+5
25 May 2016 in European Journal of Nuclear Medicine and Molecular Imaging
Journal Article
CLClaudio Liguori
Claudio LiguoriACAgostino Chiaravalloti
Agostino ChiaravallotiGSGiuseppe Sancesario
Giuseppe Sancesario
ASAlessandro Stefani
Alessandro StefaniGSGiulia Sancesario
Giulia SancesarioMPMariangela Pierantozzi
Mariangela Pierantozzi
+2
1 December 2021 in Sleep Medicine Reviews
Journal Article
Anti-seizure medications (ASMs) may improve or be detrimental to sleep. A literature review (as an update to the 2014 review by Jain and Glauser [https://doi.org/10.1111/epi.12478]) of 25 ASMs of interest (articles from 12 ASMs included) on the effect of ASMs/non-drug treatments on sleep in patients with epilepsy was conducted. The most common objective instrument was polysomnography, and the most common subjective measures were the Epworth Sleepiness Scale and the Pittsburgh Sleep Quality Index. Eslicarbazepine acetate, lacosamide, and perampanel improved or had no effect on sleep. Perampanel was associated with low incidence of insomnia, and lacosamide with low incidence of daytime sleepiness adverse events. Clonazepam, felbamate, lamotrigine, oxcarbazepine, and phenobarbital worsened or had no effect on sleep. Lamotrigine may be associated with insomnia risk and phenobarbital with daytime sleepiness. Data for valproic acid were mixed. Overall, cannabidiol, carbamazepine, and levetiracetam had no effect on sleep. Epilepsy surgery may benefit sleep in patients with a good surgical outcome. Some ASMs, and, possibly, epilepsy surgery, may have positive effects on sleep, possibly linked to achieving seizure control. Nonetheless, other ASMs may worsen sleep in some settings. Clinicians should consider such observations when making treatment decisions, particularly for patients with comorbid sleep disorders.
About Me
Claudio Liguori graduated in Medicine and Surgery from the University of Rome Tor Vergata (Italy) and specialized in Neurology at the University of Roma La Sapienza (Italy). He carried out a PhD in neuroscience on sleep, epilepsy and neurodegeneration at the University of Rome Tor Vergata.
He was a Postgraduate Junior Researcher in Neurology in 2020 and became a Senior Researcher in 2021 at the Department of Systems Medicine, University of Rome Tor Vergata, where he currently is an Assistant Professor in Neurology. He has a license for Associate Professor in Neurology and an active role in undergraduate and postgraduate teaching in Neurology. He is the author of more than 140 publications in peer-reviewed journals and 5 book chapters, the Review Editor of several journals, the Principal Investigator of clinical research projects (sleep, epilepsy), and an Editorial Member of Journal of Alzheimer Disease, Plos One, Journal of Personalized Medicine.
Member of the Board of the Italian Sleep Medicine Association (AIMS) since 2022
Member of the international study group on REM behaviour disorder
Member of the European Study Group on Restless Legs Syndrome Group
Member of the study group of the SINdem (Italian society of neurology for dementia) “Sleep and neurodegenerative disorders”
Member of the study group of the SIN(Italian society of neurology) “Bioethics and palliative care”
Member of the International Faculty of the International Master in Sleep Medicine, 2023-2025