West Africa is facing the challenge of its population’s food insecurity in a context of accelerated degradation of natural resources. In order to efficiently face this double bottleneck, agroecological interventions were implemented as a way to promote best agricultural practices. Agroecology is a mode of production that nowadays questions our food system which, despite technological progress, still struggles to feed the world’s population. This systematic review is part of the vision of a deep agroecology and aims at analyzing the institutional, political, organizational, and social obstacles and levers for an agroecological transition and its amplification in Burkina Faso and Benin. For this purpose, a structured literature review was conducted using grey and published literature. It appears that despite the mitigated results of the implementation of the Green Revolution model of agricultural production in West Africa, African public authorities seem to have placed once again their faith in conventional production practices to respond to the challenges facing agriculture in the region. This situation goes beyond the regional framework to take root at the national level, (e.g., Burkina Faso, Benin), with the corollary of an apparent lack of institutional interest in sustainable modes of production. However, there is a network of stakeholders who are developing promising initiatives for scaling up agroecological practices.